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EMCYT
Prostate and other male cancers
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Drug Name:

EMCYT Rx

Generic Name and Formulations:
Estramustine phosphate sodium (prodrug of estradiol) 140mg; caps.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for EMCYT:

Palliative of metastatic, progressive prostate cancer.

Adult:

Take 1 hour before or 2 hours after meals. 14mg/kg in 3 or 4 divided doses; reevaluate after 30 to 90 days. Continue as long as favorable response maintained.

Children:

Not applicable.

Contraindications:

Active thrombophlebitis or thromboembolic disorders (except when tumor mass caused by thromboembolic phenomenon). Allergy to estradiol, nitrogen mustard.

Warnings/Precautions:

History of thrombophlebitis, thrombosis, thromboembolic disorders. Cerebro- or cardiovascular disease. Diabetes. Hypertension. Conditions aggravated by fluid retention. Renal or hepatic dysfunction. Monitor bilirubin and hepatic enzymes during and for 2 months after treatment is discontinued. Metabolic bone diseases associated with hypercalcemia. Use effective contraception.

Interactions:

Absorption impaired by calcium.

Adverse Reactions:

Edema, dyspnea, leg cramps; nausea, diarrhea, GI upset; pruritus, dry skin, easy bruising; breast tenderness and enlargement; lethargy, emotional lability, insomnia; leucopenia; abnormal bilirubin, LDH, SGOT. Thrombosis, MI.

How Supplied:

Caps—100

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