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Doxycycline Hyclate Delayed-Release Tablets
Acne
Bacterial infections
Malaria
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Drug Name:

Doxycycline Hyclate Delayed-Release Tablets Rx

Generic Name and Formulations:
Doxycycline (as hyclate) 50mg, 150mg, 200mg.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Doxycycline Hyclate Delayed-Release Tablets:

Adjunct in severe acne.

Adult:

Take with fluids. Tablets may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. 100mg every 12hrs for 1 day, then 100mg daily; reduce dose after improvement.

Children:

Not applicable.

Warnings/Precautions:

Monitor blood, renal, and hepatic function in long-term use. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Avoid sunlight or UV light. Discontinue if skin erythema, superinfection develops. Labor & delivery. Pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:

Antacids, aluminum, iron, calcium, magnesium, bismuth subsalicylate reduce absorption. Avoid concomitant penicillins, methoxyflurane, isotretinoin. Carbamazepine, barbiturates, hydantoins decrease effectiveness. Monitor prothrombin time with oral anticoagulants. Oral contraceptives may be less effective.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, hemolytic anemia; teeth discoloration, intracranial hypertension, C.difficile-associated diarrhea.

Note:

Formerly known under the brand name Doryx.

How Supplied:

Contact supplier.

Indications for Doxycycline Hyclate Delayed-Release Tablets:

Tetracycline-susceptible infections including respiratory, genitourinary, rickettsial, trachoma, specific bacterial (eg, relapsing fever). Alternative for selected infections when penicillin is contraindicated. Anthrax including inhalational anthrax (postexposure).

Adult:

Take with fluids. Tablets may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. 100mg every 12hrs for 1 day; then 100mg daily; if severe: 100mg every 12hrs. Streptococcal infections: continue for 10 days. Uncomplicated urethral or endocervical: 100mg twice daily or 200mg once daily for 7 days; rectal: 100mg twice daily for 7 days. Uncomplicated gonococcal: 100mg twice daily for 7 days or as an alternative single visit dose: 300mg stat, followed in one hr by a second 300mg dose. Nongonococcal urethritis: 100mg twice daily for 7 days. Early syphilis: (allergic to penicillin): 100mg twice daily for 2 weeks; syphilis >1 year's duration: treat for 4 weeks. Acute epididymo-orchitis: 100mg twice daily for at least 10 days. Postexposure inhalational anthrax: 100mg twice daily for 60 days.

Children:

<8yrs: usually not recommended. Take with fluids. Tablets may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. ≥8yrs (≤45kg): 4.4mg/kg divided in 2 doses for 1 day; then 2.2mg/kg daily in 1–2 doses; if severe: up to 4.4mg/kg daily; (>45kg): use adult dose. Postexposure inhalational anthrax: (<45kg): 2.2mg/kg orally twice daily for 60 days. (≥45kg): use adult dose.

Warnings/Precautions:

Monitor blood, renal, and hepatic function in long-term use. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Avoid sunlight or UV light. Discontinue if skin erythema, superinfection develops. Labor & delivery. Pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:

Antacids, aluminum, iron, calcium, magnesium, bismuth subsalicylate reduce absorption. Avoid concomitant penicillins, methoxyflurane, isotretinoin. Carbamazepine, barbiturates, hydantoins decrease effectiveness. Monitor prothrombin time with oral anticoagulants. Oral contraceptives may be less effective.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, hemolytic anemia; teeth discoloration, intracranial hypertension, C.difficile-associated diarrhea.

Note:

See MMWR Vol 50, No.42 (Oct. 26, 2001) for more information on anthrax.

How Supplied:

Contact supplier.

Indications for Doxycycline Hyclate Delayed-Release Tablets:

Prophylaxis of malaria.

Adult:

Take with fluids. Tablets may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. Begin 1 or 2 days before travel to the malarious area, continue daily during travel and for 4 weeks after leaving the area. 100mg daily.

Children:

≤8yrs: not recommended. Take with fluids. Tablets may be broken up (in pellets) and sprinkled on a spoonful of applesauce; swallow mixture immediately without chewing and followed by a glass of water. Begin 1 or 2 days before travel to the malarious area, continue daily during travel and for 4 weeks after leaving the area. >8yrs: 2mg/kg once daily up to the adult dose.

Warnings/Precautions:

Monitor blood, renal, and hepatic function in long-term use. Overweight women. History of intracranial hypertension. Monitor for visual disturbances. Avoid sunlight or UV light. Discontinue if skin erythema, superinfection develops. Labor & delivery. Pregnancy (Cat.D), nursing mothers: not recommended.

Interactions:

Antacids, aluminum, iron, calcium, magnesium, bismuth subsalicylate reduce absorption. Avoid concomitant penicillins, methoxyflurane, isotretinoin. Carbamazepine, barbiturates, hydantoins decrease effectiveness. Monitor prothrombin time with oral anticoagulants. Oral contraceptives may be less effective.

Pharmacological Class:

Tetracycline antibiotic.

Adverse Reactions:

Anorexia, nausea, vomiting, diarrhea, rash, photosensitivity, urticaria, hemolytic anemia; teeth discoloration, intracranial hypertension, C.difficile-associated diarrhea.

Note:

Formerly known under the brand name Doryx.

How Supplied:

Contact supplier.

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