Depressive Disorders

Effects of Depressive Symptoms on Cognition, Markers of Brain Aging

Effects of Depressive Symptoms on Cognition, Markers of Brain Aging

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These findings suggest a strong association between greater depressive symptoms and markers of brain aging as well as impaired episodic memory.

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

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A substantial proportion of these individuals diagnosed with HIV, psychiatric disorders, and substance use disorders are out of care and urgently require intervention.

Antidepressant Use May Be Linked With Sustained Risk for Weight Gain

Antidepressant Use May Be Linked With Sustained Risk for Weight Gain

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Widespread use of antidepressants may be contributing to long-term increased risk for weight gain.

Family History of Psychiatric Disorders an Important Predictor of Postpartum Psychiatric Illness

Family History of Psychiatric Disorders an Important Predictor of Postpartum Psychiatric Illness

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When assessing risk for postpartum episodes, clinicians should inquire about family history of psychiatric disorders broadly and not limit discussion to postpartum psychiatric disorders or psychiatric disorders in female relatives.

Gender-Related Association Between Physical Activity, Psychological Status in T2D

Gender-Related Association Between Physical Activity, Psychological Status in T2D

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Sedentary behavior is closely linked to a more articulated pattern of psychological variables, largely influenced by sex-related differences in the individual psychological characteristics.

Depressive Symptoms Predict Future Pain, Disability in Adolescent JIA

Depressive Symptoms Predict Future Pain, Disability in Adolescent JIA

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Baseline depressive symptoms were associated with pain and disability in adolescents with juvenile idiopathic arthritis.

Gender May Not Affect Depression Risk During Interferon Therapy for Hepatitis C

Gender May Not Affect Depression Risk During Interferon Therapy for Hepatitis C

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Gender may not influence vulnerability for developing new-onset depression during interferon-alpha therapy.

Sertraline Effective for Treating Depression in Vascular Cognitive Impairment

Sertraline Effective for Treating Depression in Vascular Cognitive Impairment

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A placebo-controlled study could further clarify these results and possibly strengthen the case for antidepressant treatment for depression in vascular cognitive impairment.

Review Examines the Effectiveness of Antidepressants for Insomnia

Review Examines the Effectiveness of Antidepressants for Insomnia

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Despite the widespread use of antidepressants for treating insomnia, the evidence for their effectiveness remains limited.

Rates of Major Depression Up Among US Insured, Especially Youth

Rates of Major Depression Up Among US Insured, Especially Youth

Diagnoses of major depression have increased since 2013, particularly among adolescents and millennials.

Circadian Rhythm Disruptions Associated With Mood Disorders, Adverse Quality of Life

Circadian Rhythm Disruptions Associated With Mood Disorders, Adverse Quality of Life

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This study had a sample size large enough to assess the effect of circadian disruption on mental health disorders, and was the first to objectively measure patterns of rest and activity (using accelerometers).

Why Treating Major Depressive Disorder Improves Outcomes in HIV

Why Treating Major Depressive Disorder Improves Outcomes in HIV

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Mental health problems are 1 of the most important reasons for failing to engage in long-term control of HIV.

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

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Multimarker inflammatory biosignatures are expected to facilitate diagnosis and predict treatment outcomes for various central nervous system disorders, particularly Alzheimer disease and major depressive disorder.

Child Developmental Milestones Hindered by Maternal Depressive Symptoms

Child Developmental Milestones Hindered by Maternal Depressive Symptoms

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Investigators assessed whether depressive symptoms during and after pregnancy were associated with neurodevelopmental disadvantages in children.

Depression in Patients With Dementia May Increase Risk for Heart Disease

Depression in Patients With Dementia May Increase Risk for Heart Disease

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Clinicians should take depression into careful consideration when treating patients with Alzheimer dementia, as the two conditions combined may predispose patients to cardiovascular disease more than either condition alone.

Novel Buprenorphine Combination Therapy Shows Efficacy for MDD in Long-Term Trial

Novel Buprenorphine Combination Therapy Shows Efficacy for MDD in Long-Term Trial

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The average MADRS-10 scores decreased from baseline, and this decrease was maintained at the end of the study.

Trintellix Labeling Updated With Data on Improved Processing Speed in MDD

Trintellix Labeling Updated With Data on Improved Processing Speed in MDD

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Lundbeck announced that the Food and Drug Administration has approved a supplemental New Drug Application for Trintellix.

Mental Health Comorbidity Examined in Transgender and Gender-Nonconforming Youth

Mental Health Comorbidity Examined in Transgender and Gender-Nonconforming Youth

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These findings suggest an urgent need for improved measures of social and clinical support in transgender and/or gender-nonconforming youth.

Cumulative Depression Increases Mortality in Women With HIV

Cumulative Depression Increases Mortality in Women With HIV

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Findings highlight the clinical importance of enhanced treatment protocols designed to reduce the duration and frequency of depressive episodes in women living with HIV.

Intranasal Esketamine Rapidly Improves Symptoms of Depression and Suicidality

Intranasal Esketamine Rapidly Improves Symptoms of Depression and Suicidality

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Although there were no indications of esketamine dependence, misuse, diversion, or withdrawal symptoms in this trial, this is a possible concern, and the authors call for further evidence from clinical trials to evaluate the drug's potential for abuse.

Grip Strength Indicative of Cognition in Major Depression

Grip Strength Indicative of Cognition in Major Depression

For individuals with major depression and bipolar disorder, grip strength is positively associated with cognition.

NDA Submitted for Postpartum Depression Treatment Brexanolone

NDA Submitted for Postpartum Depression Treatment Brexanolone

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Results in the 202B and 202C trials showed that brexanolone achieved the primary endpoint of mean reduction from baseline in the Hamilton Rating Scale for Depression.

Children of Consanguineous Marriage at Increased Risk for Mood Disorders, Psychoses

Children of Consanguineous Marriage at Increased Risk for Mood Disorders, Psychoses

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Communities that favor consanguineous marriage should receive sensitive advice on the risks involved to aid in reproductive decision making.

Psychiatric Comorbidities Increase Neurologic Disability in Multiple Sclerosis

Psychiatric Comorbidities Increase Neurologic Disability in Multiple Sclerosis

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Patients with MS and comorbid psychiatric conditions have increased severity of subsequent neurological disability.

Collaborative care intervention does not improve health in chronic heart failure, but alleviates depression and fatigue

Collaborative Care to Alleviate Symptoms and Adjust to Illness (CASA), a collaborative care intervention combining symptom and psychosocial care, did not improve heart failure-specific health status in chronic heart disease compared with usual care. When compared with usual care, CASA did improve secondary outcomes of depression and fatigue.

Prenatal SSRI Exposure Associated With Fetal Neurodevelopmental Changes

Prenatal SSRI Exposure Associated With Fetal Neurodevelopmental Changes

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These data indicate a potential association between prenatal SSRI exposure and the development of the fetal amygdala-insula circuit, possibly via anomalous serotonin signaling.

Increased Prevalence of Depression, Anxiety After Colorectal Cancer

Increased Prevalence of Depression, Anxiety After Colorectal Cancer

The prevalence of depression and anxiety are increased among survivors of colorectal cancer.

Psychiatric Illness, Not Antidepressants, Associated With Breast Milk Insufficiency

Psychiatric Illness, Not Antidepressants, Associated With Breast Milk Insufficiency

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Mothers struggling with depression may benefit from additional breastfeeding education and support.

Children With Autism, ADHD at Increased Risk for Anxiety, Mood Disorders

Children With Autism, ADHD at Increased Risk for Anxiety, Mood Disorders

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Recognizing the increased risk for mood disorders in children with ASD and ADHD may be useful for clinicians and parents in developing proper screening and treatment strategies.

Clinical Outcomes Assessed for Major Depressive Disorder With Psychotic Features

Clinical Outcomes Assessed for Major Depressive Disorder With Psychotic Features

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Major depressive disorder with psychotic features had comparative long-term outcomes with schizophrenia, schizoaffective disorder, and bipolar disorder.

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