Depressive Disorder News Archive

Depressive Symptoms Have Greater Negative Effect on MS Functional Outcomes Than Anxiety

Depressive Symptoms Have Greater Negative Effect on MS Functional Outcomes Than Anxiety

The authors noted a potential for a complex and dynamic relationship between depression and functional outcomes in multiple sclerosis , with greater dysfunction possibly increasing levels of depression.

Pain, Depression, and Opioid Misuse May Be Associated With Drug Overdoses

Pain, Depression, and Opioid Misuse May Be Associated With Drug Overdoses

Pain conditions may largely be underrecognized contributors to the overdose epidemic.

Antidepressant Effects of Ketamine Appear to Require Opioid System Activation

Antidepressant Effects of Ketamine Appear to Require Opioid System Activation

Researchers conducted a double-blind crossover study in adults with treatment-resistant depression to determine the involvement of the opioid system in ketamine's antidepressant effects.

Cost-Effective Telehealth Alternatives for Veterans With Depression

Cost-Effective Telehealth Alternatives for Veterans With Depression

Researchers working with a population of veterans found that the healthcare utilization costs of telehealth services were significantly cheaper compared with in-person visits, with only a relatively small difference in quality of life.

Gestational Diabetes Associated With Increased Risk for Postpartum Depression

Gestational Diabetes Associated With Increased Risk for Postpartum Depression

These findings suggest an increased risk for postpartum depressive symptoms in mothers with gestational diabetes, independent of depressive symptomatology during pregnancy.

Combination Cognitive Behavioral Therapy With Fluoxetine Effective for Adolescent Depression

Combination Cognitive Behavioral Therapy With Fluoxetine Effective for Adolescent Depression

This research suggests that combination therapy not only produces greater proportional response in depression symptoms but that it is also effective in a broader range of individuals.

Selective Serotonin Reuptake Inhibitors May Increase Risk for Suboptimal Fetal Growth

Selective Serotonin Reuptake Inhibitors May Increase Risk for Suboptimal Fetal Growth

Use of serotonin reuptake inhibitors for maternal depression may increase the risk for low birth weight in children.

Transdermal Nicotine Boosts Mood and Cognitive Function in Late-Life Depression

Transdermal Nicotine Boosts Mood and Cognitive Function in Late-Life Depression

Results showed a significant change in depression severity with a mean MADRS reduction of 18.45 and a response rate of 86.7%.

Ketamine Infusions Reduce Suicidal Ideation in Depression: Characterizing Different Responses

Ketamine Infusions Reduce Suicidal Ideation in Depression: Characterizing Different Responses

Researchers found 3 distinct subgroups of patients in relation to suicidal ideation and effects of ketamine, with one group's suicidal ideation completely eliminated and the other group's improvement independent of depressed mood.

Sex Differences in Comorbid Chronic Pain and Depression Examined

Sex Differences in Comorbid Chronic Pain and Depression Examined

Chronic neuropathic pain has a large impact on quality of life and often causes or increases depressive symptoms for both men and women.

White Matter Microstructure Variations Increase Risk for Depression in Adolescents

White Matter Microstructure Variations Increase Risk for Depression in Adolescents

These adolescents may have delayed white matter maturation or early alterations in tracts connecting the anterior corpus callosum to the anterior cingulate cortex, which may carry a high risk for transition to depression.

Combinatorial Pharmacogenetics Useful in Treatment for Depression

Combinatorial Pharmacogenetics Useful in Treatment for Depression

These data support the clinical use of combinatorial pharmacogenetics for patients with major depressive disorder.

Identifying Trajectory Classes of Postpartum Depressive Symptoms

Identifying Trajectory Classes of Postpartum Depressive Symptoms

The high-risk class was associated with risk factors such as complications after birth, elevated depressive symptoms during pregnancy, and previous mental illness.

Guidelines for Managing Perimenopausal Depression Now Available

Guidelines for Managing Perimenopausal Depression Now Available

The first-ever guidelines for the evaluation and treatment of perimenopausal depression have been published.

Esketamine Nasal Spray NDA Submitted to FDA for Treatment-Resistant Depression

Esketamine Nasal Spray NDA Submitted to FDA for Treatment-Resistant Depression

The NDA includes five Phase 3 studies in patients with treatment-resistant depression: 3 short-term studies, 1 withdrawal maintenance of effect study, and 1 long-term safety study.

Improving Psychotherapy Dosing for Comorbid Depression and Personality Disorders

Improving Psychotherapy Dosing for Comorbid Depression and Personality Disorders

Researchers are conducting a trial to determine whether 25 or 50 psychotherapy sessions in a year will be more effective at reducing symptoms of depression in patients with personality disorders.

Parental Religiosity May Lower Risk for Suicidal Ideation in Offspring

Parental Religiosity May Lower Risk for Suicidal Ideation in Offspring

This study suggests that parental spirituality may affect offspring mental health, particularly regarding suicidal behaviors.

Lurasidone Effective for Treatment of Depression, Not Associated With Sexual Dysfunction

Lurasidone Effective for Treatment of Depression, Not Associated With Sexual Dysfunction

These data suggest that lurasidone is effective in treating major depressive disorder with manic features without introducing sexual dysfunction.

Psilocybin Study Gets Green Light From FDA for Treatment-Resistant Depression

Psilocybin Study Gets Green Light From FDA for Treatment-Resistant Depression

The trial will be a Phase 2b dose-ranging study (N=216) with patients from 12-15 research centers across Europe and North America.

Symptoms of Sleep Disorders Prevalent in Psychiatric Illnesses

Symptoms of Sleep Disorders Prevalent in Psychiatric Illnesses

The authors argue that identifying and treating sleep disorders during early stages may have a positive impact on outcomes in psychiatric patients.

Reducing Off-Label Quetiapine Prescribing the Old-Fashioned Way: Snail Mail

Reducing Off-Label Quetiapine Prescribing the Old-Fashioned Way: Snail Mail

Despite the associated risk for death and cognitive decline, "off-label" prescribing of antipsychotics in patients with dementia has increased.

Cortisol Levels May Contribute to Global Cognitive Decline in Elderly Adults With Depression

Cortisol Levels May Contribute to Global Cognitive Decline in Elderly Adults With Depression

These data indicate that cortisol levels may contribute to the cognitive decline observed in elderly adults with late-life depression.

Deep Transcranial Magnetic Stimulation Combined With SSRIs Possibly Effective for Treatment-Resistant Depression

Deep Transcranial Magnetic Stimulation Combined With SSRIs Possibly Effective for Treatment-Resistant Depression

These results suggest that deep transcranial magnetic stimulation combined with selective serotonin reuptake inhibitors may be effective in assisting patients with treatment-resistant depression.

Amount of Physical Exercise Affects Mental Health Burden

Amount of Physical Exercise Affects Mental Health Burden

Physical exercise is associated with self-reported mental health burden in the past month.

Factors Associated With Transfer to Specialized Mental Health Care in Anxiety, Depression

Factors Associated With Transfer to Specialized Mental Health Care in Anxiety, Depression

Demographic characteristics predictive of transfer to specialized services included younger age and higher education level.

Symptoms of Anxiety, Depression Differ Depending on Gender, Race, Ethnicity

Symptoms of Anxiety, Depression Differ Depending on Gender, Race, Ethnicity

There is sufficient evidence to suggest that physiology and culture underlie some of the variation in how depression and anxiety symptoms can manifest.

Significant Rates of Major Depressive Disorder Found in Dementia

Significant Rates of Major Depressive Disorder Found in Dementia

Patients with dementia had an increased prevalence of major depressive disorder.

Behavioral Executive Dysfunction Associated With Chronic Kidney Disease

Behavioral Executive Dysfunction Associated With Chronic Kidney Disease

Further assessment of this relationship and its underlying mechanisms may help clinicians anticipate the likelihood of patients' adherence to risk-reducing habits.

Many Americans Not Being Assessed for Depression

Many Americans Not Being Assessed for Depression

Many Americans aged 35 and older are not being assessed for depression.

Both Abstinence and High Alcohol Use Linked to Dementia

Both Abstinence and High Alcohol Use Linked to Dementia

Abstinence in midlife and consumption of more than 14 units of alcohol per week are associated with increased risk of dementia.

Paternal Depression Rates Comparable to Maternal Depression Rates

Paternal Depression Rates Comparable to Maternal Depression Rates

These data indicate that paternal depression is a substantial burden for the parent population that warrants research into appropriate intervention methods.

Appetitive Symptoms, Fluoxetine, and Light Therapy: Predicting Treatment Response for Nonseasonal Major Depression

Appetitive Symptoms, Fluoxetine, and Light Therapy: Predicting Treatment Response for Nonseasonal Major Depression

Researchers examined whether more severe appetitive symptoms predicted a positive response to light therapy.

Short Form of Geriatric Depression Scale May Be Useful Assessment Tool Across Adult Lifespan

Short Form of Geriatric Depression Scale May Be Useful Assessment Tool Across Adult Lifespan

The GDS-15 uses short sentences and a yes/no format, which is easier for patients who are struggling with depression, fatigue, or cognitive impairment to tolerate.

Parental Depression Associated With Increased Healthcare Utilization in Children, Adolescents

Parental Depression Associated With Increased Healthcare Utilization in Children, Adolescents

A combination of factors may have been responsible for the association between parental depression and increased healthcare visits in their children, including shared genetic risks.

Antidepressants and Bleeding Risk: What's the Link?

Antidepressants and Bleeding Risk: What's the Link?

Results showed an increased risk of bleeding with SRIs by 1.16-2.36 times with an even higher 3.17- to 10.9-fold risk with concomitant NSAIDs.

Depression Associated With More Severe Disease Activity, Functional Impairment in axSpA

Depression Associated With More Severe Disease Activity, Functional Impairment in axSpA

Depression is common in patients with axSpA and is associated with more severe disease activity and functional impairment.

Marijuana Use Associated With Poorer Depression Outcomes, Increased Suicidal Ideation

Marijuana Use Associated With Poorer Depression Outcomes, Increased Suicidal Ideation

These data suggest that marijuana use, particularly non-medical use, is associated with poorer depression and anxiety outcomes in psychiatric patients.

Brain Region Connectivities Mediate the Association Between Depression and Sleep Quality

Brain Region Connectivities Mediate the Association Between Depression and Sleep Quality

These data suggest a neurologic basis for the relationship between sleep quality and depressive symptoms, even among patients with no clinical diagnosis of depression.

Escitalopram Treatment After Acute Coronary Syndrome May Improve Long-term Outcomes

Escitalopram Treatment After Acute Coronary Syndrome May Improve Long-term Outcomes

Depression is associated with poorer outcomes in ACS and these findings suggest that this course of treatment may improve long-term major adverse cardiac event outcomes.

Parent-Child Interactive Intervention Cuts Depression

Parent-Child Interactive Intervention Cuts Depression

An intervention targeting depression in very young children can be effective in community settings.

Certain Neuroinflammatory Biomarkers Associated With Depressive Symptoms

Certain Neuroinflammatory Biomarkers Associated With Depressive Symptoms

These data substantiate claims that certain neuroinflammatory biomarkers may predict depression symptoms or severity and could be useful in developing diagnostic and treatment strategies.

High-Frequency, Repetitive TMS May Reduce Suicidal Ideation in Adolescents With Depression

High-Frequency, Repetitive TMS May Reduce Suicidal Ideation in Adolescents With Depression

Researchers believe this therapy shows potential as a brain-based approach for correcting cortical physiologic deficits in this population.

Food Addiction Phenotype in Obesity Associated With Higher Risk for Mood, Anxiety Disorders

Food Addiction Phenotype in Obesity Associated With Higher Risk for Mood, Anxiety Disorders

The researchers noted that these findings highlight the complexity of obesity as a disease that shares a common etiology with some psychiatric and addictive disorders.

Antenatal Depression Associated With Altered Behavior in Offspring

Antenatal Depression Associated With Altered Behavior in Offspring

The results showed that women with antenatal MDD have abnormal stress-related inflammation and cortisol levels, a shorter gestational length, neonates with suboptimal neurobehavioral function, and their 1-year-old infants have increased cortisol reactivity to stress.

Affective Instability Is an Important Predictor of Major Depressive Disorder

Affective Instability Is an Important Predictor of Major Depressive Disorder

Findings revealed that women's self-reported affective instability predicted depressive symptoms over time.

Pregnant Women Today May Be at Higher Risk for Prenatal Depression Than Their Mothers' Generation

Pregnant Women Today May Be at Higher Risk for Prenatal Depression Than Their Mothers' Generation

Prenatal depression may be more common today among young pregnant women than among women in their mothers' generation.

Depression, Apathy Associated With Increased Risk for Mild Cognitive Impairment

Depression, Apathy Associated With Increased Risk for Mild Cognitive Impairment

Adults with depressive symptoms and apathy in middle and late life were at a higher risk for conversion to mild cognitive impairment (MCI) and dementia.

FDA Fast-Tracks Novel Treatment for Major Depressive Disorder

FDA Fast-Tracks Novel Treatment for Major Depressive Disorder

An investigational treatment for major depressive disorder, AGN-241751, has been granted Fast Track designation by the FDA.

Problem Solving Helps Prevent Depression in Low-Income Moms

Problem Solving Helps Prevent Depression in Low-Income Moms

Problem-solving education is effective at preventing depressive symptoms among low-income mothers.

Omega-3 Fatty Acids Offer No Therapeutic Advantage Over Placebo for Adolescent Depression

Omega-3 Fatty Acids Offer No Therapeutic Advantage Over Placebo for Adolescent Depression

These results challenge existing conceptions that omega-3 fatty acids may be effective in treating adolescent major depressive disorder.

Early Treatment for Depression in Bereaved Youth Improves Future Psychiatric Health

Early Treatment for Depression in Bereaved Youth Improves Future Psychiatric Health

Bereaved children were more likely to experience depression, and children who lost a parent before the age of 12 were more likely to experience depression within the first 2 years.

Exposure to Antidepressants in Utero May Affect Childhood Motor Development

Exposure to Antidepressants in Utero May Affect Childhood Motor Development

While the findings do not warrant a change in current prescribing practices, researchers advocate monitoring at-risk children in light of the increased use of antidepressants during pregnancy.

Lipophilic Statins Not Associated With Significant Increase in Risk for Depression

Lipophilic Statins Not Associated With Significant Increase in Risk for Depression

Research has suggested a number of possible relationships with lipophilic statins, including a protective phenomenon against depression and higher risk for dementia, although these associations remain controversial.Research has suggested a number of possible relationships with lipophilic statins, including a protective phenomenon against depression and higher risk for dementia, although these associations remain controversial.

Fatigue a Potential Indicator of Overlapping Sleep Apnea and COPD

Fatigue a Potential Indicator of Overlapping Sleep Apnea and COPD

On the basis of these findings, researchers recommended that "[f]atigue should be evaluated whenever there is clinical suspicion of overlap syndrome."

Novel Parent-Child Interaction Therapy Targets Preschool-Aged Depression

Novel Parent-Child Interaction Therapy Targets Preschool-Aged Depression

Children in the waiting list group exhibited significantly worse impairments on the Preschool Feelings Checklist at the study's end, but children who completed the therapy showed improvements in emotion regulation and guilt processing.

Midlife Fitness Associated With Lower Risk for Depression and CVD Death

Midlife Fitness Associated With Lower Risk for Depression and CVD Death

These results demonstrate the importance of midlife fitness to prevent depression and subsequent CVD mortality in older age.

Depression, Anxiety May Correlate With Disease Activity in Early Rheumatoid Arthritis

Depression, Anxiety May Correlate With Disease Activity in Early Rheumatoid Arthritis

This research provides further support to compelling data linking inflammation and depression.

Remission of Treatment-Resistant Depression in Veterans Depends on Close Clinical Observation

Remission of Treatment-Resistant Depression in Veterans Depends on Close Clinical Observation

This study supports the effects of close clinical observation and the use of combined treatment interventions including repetitive transcranial magnetic stimulation for achieving remission in veterans with treatment-resistant depression.

Depression Associated With Balance Impairments in Multiple Sclerosis

Depression Associated With Balance Impairments in Multiple Sclerosis

Investigators note that depression should be evaluated and treated in patients with multiple sclerosis and may hinder balance rehabilitation.

Increased Suicide Risk in Cardiovascular Disease With Highest Rates in Younger Patients

Increased Suicide Risk in Cardiovascular Disease With Highest Rates in Younger Patients

Patients with these cardiovascular diseases would benefit from early psychiatric help.

Cannabis Associated With Poorer Symptom Course in Anxiety, Mood Disorders

Cannabis Associated With Poorer Symptom Course in Anxiety, Mood Disorders

These data may be useful to clinicians in gaining insight on the potential risks of cannabis use among their patients with anxiety or mood disorders.

Technology-Enhanced Intervention in the ED Appears Promising for Reducing Underage Drinking, Consequences

Technology-Enhanced Intervention in the ED Appears Promising for Reducing Underage Drinking, Consequences

This intervention provides flexibility in the clinical setting, allowing for therapist delivery when staff is available and computer delivery when staff resources are not available.

Brexpiprazole Effective as Adjunct Therapy in Major Depressive Disorder

Brexpiprazole Effective as Adjunct Therapy in Major Depressive Disorder

Clinicians may find these data useful in treating patients with major depressive disorder and an inadequate response to antidepressant treatment alone.

Negative Social Media Interactions Have Significant Effects on Depressive Symptoms

Negative Social Media Interactions Have Significant Effects on Depressive Symptoms

It may be important to increase awareness of avoiding negative social media encounters to reduce the risk for depressive symptoms.

No Evidence Found That Efavirenz Use Increases Depression in HIV Antiretroviral Therapy

No Evidence Found That Efavirenz Use Increases Depression in HIV Antiretroviral Therapy

The researchers believe this study is the first to detect a statistically significant, unexpected inverse association between efavirenz use and depression.

Older Age Associated With Worse Major Depressive Disorder Outcomes

Older Age Associated With Worse Major Depressive Disorder Outcomes

The age association remained significant after additional adjustments for clinical and social factors such as loneliness and pain. As such, age-specific factors cannot alone explain the poorer MDD course associated with older age.

Women With Epilepsy More Likely to Have Major Depressive Disorder

Women With Epilepsy More Likely to Have Major Depressive Disorder

Investigators sought to determine the frequency of major depressive disorder in patients in epilepsy clinics.

Cognitive Performance, Mood Deficits, White Matter Hyperintensities in Migraine

Cognitive Performance, Mood Deficits, White Matter Hyperintensities in Migraine

Carefully assessing cognitive performance using a screening test to detect visuospatial/executive, attention, and memory dysfunction in patients with migraine.

Medications With Adverse Effect of Depression Are Commonly Used

Medications With Adverse Effect of Depression Are Commonly Used

An estimated 37.2% of people in the United States use medications that have an adverse effect of depression.

Loneliness, Low Social Support Associated With Poorer Mental Health Outcomes

Loneliness, Low Social Support Associated With Poorer Mental Health Outcomes

Preliminary generalizations point toward the potential therapeutic efficacy of targeting loneliness and social support for patients.

Belief That Abortion Harms Women's Mental Health Appears Misinformed

Belief That Abortion Harms Women's Mental Health Appears Misinformed

The notion that abortion harms women's mental health may be misinformed and should be re-examined according to scientific data such as these.

Caffeine Sodium Benzoate Effective as Electroconvulsive Therapy Augmentation

Caffeine Sodium Benzoate Effective as Electroconvulsive Therapy Augmentation

This study was prompted by an ongoing shortage of injectable caffeine sodium benzoate in the United States from 2011 to 2017.

Psychiatric Morbidity Decreased After Assisted Reproductive Technology Treatment

Psychiatric Morbidity Decreased After Assisted Reproductive Technology Treatment

These analyses may serve clinicians in addressing potential psychiatric obstacles in patients undergoing fertility treatments.

Efficacy of 1-on-1 Intervention for Mothers and Babies for Postpartum Depression

Efficacy of 1-on-1 Intervention for Mothers and Babies for Postpartum Depression

These data may be helpful in developing targeted interventions for women at risk for postpartum depression.

When Antidepressants Fail, Dose Increase May Be a Less Effective Response

When Antidepressants Fail, Dose Increase May Be a Less Effective Response

As this and previous research on dose increase strategies have produced inconsistent findings, the researchers recommended clinicians consider other responses to antidepressant treatment failure, at least for selective serotonin reuptake inhibitors.

Examining Treatment Modalities for Noninvasive Brain Stimulation for Adult Depression

Examining Treatment Modalities for Noninvasive Brain Stimulation for Adult Depression

These data could be useful to clinicians and patients alike in selecting the proper treatment method.

Esketamine Nasal Spray: A New Treatment Possibility for Treatment-Resistant Depression

Esketamine Nasal Spray: A New Treatment Possibility for Treatment-Resistant Depression

The Janssen Pharmaceutical Companies of Johnson & Johnson have announced the results of 2 long-term phase 3 clinical trials examining esketamine nasal spray in patients with treatment-resistant depression.

Effects of Male, Female Major Depression on Fertility Treatment Outcomes

Effects of Male, Female Major Depression on Fertility Treatment Outcomes

Among men, those with active major depression were less likely to have a partner achieve conception.

Examining the Relationship Between Childhood Anxiety, Depression and Risk for Cardiovascular Disease

Examining the Relationship Between Childhood Anxiety, Depression and Risk for Cardiovascular Disease

The potential plasticity of the cardiovascular system during childhood may explain the lack of significant relationship between depression and anxiety symptomatology and CVD risk in this study population.

Using Psychological Vulnerability Markers to Predict the Course of Affective Disorders

Using Psychological Vulnerability Markers to Predict the Course of Affective Disorders

Routine assessments of these markers should be conducted before and during treatment as they may inform prognoses.

Pain, Cognitive Dysfunction in SLE Mediated by Sleep Disturbance, Depression

Pain, Cognitive Dysfunction in SLE Mediated by Sleep Disturbance, Depression

The relationship between pain and cognitive dysfunction was explained by sleep disturbance and depressive symptoms.

Carbamazepine, Lamotrigine May Pose Fewer Psychiatric Risks Than Other Antiepileptic Drugs

Carbamazepine, Lamotrigine May Pose Fewer Psychiatric Risks Than Other Antiepileptic Drugs

Carbamazepine, in particular, was associated with lower hazards for depression and anxiety in secondary analyses.

Major Depression in Men May Lower Chances of Conception

Major Depression in Men May Lower Chances of Conception

Active major depression in the male partner may lower the likelihood of pregnancy.

The Psychosocial Impact of Rosacea: Should Clinicians Be Concerned?

The Psychosocial Impact of Rosacea: Should Clinicians Be Concerned?

The erythematotelangiectatic, papulopustular, phymatous, and ocular forms of rosacea can lead to psychological distress.

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

HIV Viral Suppression Rates in Psychiatric Inpatients With Comorbid Substance Use Disorders

A substantial proportion of these individuals diagnosed with HIV, psychiatric disorders, and substance use disorders are out of care and urgently require intervention.

Effects of Depressive Symptoms on Cognition, Markers of Brain Aging

Effects of Depressive Symptoms on Cognition, Markers of Brain Aging

These findings suggest a strong association between greater depressive symptoms and markers of brain aging as well as impaired episodic memory.

Antidepressant Use May Be Linked With Sustained Risk for Weight Gain

Antidepressant Use May Be Linked With Sustained Risk for Weight Gain

Widespread use of antidepressants may be contributing to long-term increased risk for weight gain.

Family History of Psychiatric Disorders an Important Predictor of Postpartum Psychiatric Illness

Family History of Psychiatric Disorders an Important Predictor of Postpartum Psychiatric Illness

When assessing risk for postpartum episodes, clinicians should inquire about family history of psychiatric disorders broadly and not limit discussion to postpartum psychiatric disorders or psychiatric disorders in female relatives.

Depressive Symptoms Predict Future Pain, Disability in Adolescent JIA

Depressive Symptoms Predict Future Pain, Disability in Adolescent JIA

Baseline depressive symptoms were associated with pain and disability in adolescents with juvenile idiopathic arthritis.

Gender-Related Association Between Physical Activity, Psychological Status in T2D

Gender-Related Association Between Physical Activity, Psychological Status in T2D

Sedentary behavior is closely linked to a more articulated pattern of psychological variables, largely influenced by sex-related differences in the individual psychological characteristics.

Gender May Not Affect Depression Risk During Interferon Therapy for Hepatitis C

Gender May Not Affect Depression Risk During Interferon Therapy for Hepatitis C

Gender may not influence vulnerability for developing new-onset depression during interferon-alpha therapy.

Sertraline Effective for Treating Depression in Vascular Cognitive Impairment

Sertraline Effective for Treating Depression in Vascular Cognitive Impairment

A placebo-controlled study could further clarify these results and possibly strengthen the case for antidepressant treatment for depression in vascular cognitive impairment.

Review Examines the Effectiveness of Antidepressants for Insomnia

Review Examines the Effectiveness of Antidepressants for Insomnia

Despite the widespread use of antidepressants for treating insomnia, the evidence for their effectiveness remains limited.

Rates of Major Depression Up Among US Insured, Especially Youth

Rates of Major Depression Up Among US Insured, Especially Youth

Diagnoses of major depression have increased since 2013, particularly among adolescents and millennials.

Circadian Rhythm Disruptions Associated With Mood Disorders, Adverse Quality of Life

Circadian Rhythm Disruptions Associated With Mood Disorders, Adverse Quality of Life

This study had a sample size large enough to assess the effect of circadian disruption on mental health disorders, and was the first to objectively measure patterns of rest and activity (using accelerometers).

Why Treating Major Depressive Disorder Improves Outcomes in HIV

Why Treating Major Depressive Disorder Improves Outcomes in HIV

Mental health problems are 1 of the most important reasons for failing to engage in long-term control of HIV.

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

Multimarker inflammatory biosignatures are expected to facilitate diagnosis and predict treatment outcomes for various central nervous system disorders, particularly Alzheimer disease and major depressive disorder.

Child Developmental Milestones Hindered by Maternal Depressive Symptoms

Child Developmental Milestones Hindered by Maternal Depressive Symptoms

Investigators assessed whether depressive symptoms during and after pregnancy were associated with neurodevelopmental disadvantages in children.

Depression in Patients With Dementia May Increase Risk for Heart Disease

Depression in Patients With Dementia May Increase Risk for Heart Disease

Clinicians should take depression into careful consideration when treating patients with Alzheimer dementia, as the two conditions combined may predispose patients to cardiovascular disease more than either condition alone.

Novel Buprenorphine Combination Therapy Shows Efficacy for MDD in Long-Term Trial

Novel Buprenorphine Combination Therapy Shows Efficacy for MDD in Long-Term Trial

The average MADRS-10 scores decreased from baseline, and this decrease was maintained at the end of the study.

Sign Up for Free e-newsletters