Depressive Disorder Archive

Which Antidepressants May Cause Birth Defects?

Which Antidepressants May Cause Birth Defects?

Anything that has the potential to disturb the serotonin signaling process has the potential to result in a wide variety of malformations.

Worse Psychological Outcomes for Women Denied Abortion

Worse Psychological Outcomes for Women Denied Abortion

There is no evidence that protecting women's mental health concerns should restrict abortion access.

Modifiable Psychological Factors Influence TKA for OA

Modifiable Psychological Factors Influence TKA for OA

Psychological factors drive expectations of poor outcomes following total knee arthroplasty.

Aging a Stronger Predictor of Depression, Negative Mood Than Menopause

Aging a Stronger Predictor of Depression, Negative Mood Than Menopause

Women in the menopausal transition and early postmenopause are at higher risk for depressive symptoms and negative mood than those in late postmenopause.

Depression Medication Linked to Increased Risk of ICH

Depression Medication Linked to Increased Risk of ICH

Concomitant use of oral anticoagulants among people taking SSRIs contributed to a significantly higher risk for ICH.

Youth Depression Onset Predicted by Anxiety, Family History, Adversity

Youth Depression Onset Predicted by Anxiety, Family History, Adversity

Fear and anxiety showed the strongest correlation with development of major depression in children.

Link Found Between Tension Headaches and Anxiety, Depression

Link Found Between Tension Headaches and Anxiety, Depression

Patients with tension-type headaches had a significantly higher prevalence of anxiety and depression.

Cytokine Levels May Predict SSRI Response in Children and Adolescents

Cytokine Levels May Predict SSRI Response in Children and Adolescents

Elevated cytokine levels could help to identify children who are unlikely to respond to treatment with fluoxetine.

Executive Dysfunction in Idiopathic Depression vs Epilepsy-associated Depression

Executive Dysfunction in Idiopathic Depression vs Epilepsy-associated Depression

Individuals suffering from depression, as well as persons diagnosed with temporal lobe epilepsy, present with dysfunction across several cognitive domains.

Cigarette Smoking Predicts Development of Depression

Cigarette Smoking Predicts Development of Depression

Cigarette smoking prevalence among persons with severe mental illness is approximately 3 times greater than the rate observed in the general population.

Depressive Symptoms Linked to Shorter Survival With Lung Cancer

Depressive Symptoms Linked to Shorter Survival With Lung Cancer

Depression symptoms at baseline correlated with increased mortality among participants with early- but not late-stage disease.

Sertraline Prevents Depression Following Traumatic Brain Injury

Sertraline Prevents Depression Following Traumatic Brain Injury

Approximately 80% of depressive episodes have their onset during the first six months following traumatic brain injury.

Pupillometric Analysis For Assessment of Depression Recurrence

Pupillometric Analysis For Assessment of Depression Recurrence

Pupillary reactivity to emotional stimuli has been investigated to provide objective information about the risk for recurrence of depressive symptoms in women.

Mood Disorders and the Disrupted Gut Microbial Milieu

Mood Disorders and the Disrupted Gut Microbial Milieu

Lower diversity of microbial populations in the human gut has been identified in individuals with major depressive disorder.

Comprehensive Assessment Essential for Treating All Aspects of Pain

Comprehensive Assessment Essential for Treating All Aspects of Pain

Regular evaluation and assessment along with a personalized "step approach" is essential for effective pain management.

Internet Addiction May Signal Other Mental Health Issues

Internet Addiction May Signal Other Mental Health Issues

An over-reliance on the internet could indicate depression, anxiety, or impulsivity in college students.

Cognition in Depression: A Critical Domain for Health Outcomes, Measurement, and Treatment

Cognition in Depression: A Critical Domain for Health Outcomes, Measurement, and Treatment

Dr. Roger McIntyre suggests that the clinical relevance of cognitive dysfunction for any individual patient can only be adjudicated on a case-by-case basis.

Whole Body Hyperthermia: The Future of Depression Treatment?

Whole Body Hyperthermia: The Future of Depression Treatment?

Researchers investigated the lasting effects of whole body hyperthermia (WBH) in the first randomized, double-blind, [placebo]-controlled study of WBH for the treatment of MDD.

Does Impaired Cognition Precede Depression?

Does Impaired Cognition Precede Depression?

Dysfunction across several cognitive domains is often concomitant with depression.

"Frequent Flyers" in Emergency Department More Likely to Have Depression

"Frequent Flyers" in Emergency Department More Likely to Have Depression

"Detecting depression in the emergency department is of utmost importance," Dr. Brickman and colleagues wrote in their publication.

EEG Registry Reduces Trial-and-Error Approach to Depression Treatment

EEG Registry Reduces Trial-and-Error Approach to Depression Treatment

The registry contains more than 10,000 EEGs and 38,000 pharmacological outcomes, and is accessible to clinicians worldwide.

The Neuroanatomy of, and Cognitive Deficits in, Depression: A Brief Overview

The Neuroanatomy of, and Cognitive Deficits in, Depression: A Brief Overview

Atrophy of numerous structures within the central nervous system has been observed in persons suffering from depression.

Late-onset Depression Associated with Elevated Dementia Risk

Late-onset Depression Associated with Elevated Dementia Risk

Dementia risk was particularly elevated in patients with depression who had higher scores on cognitive tests at baseline.

Investigating Risk Factors for Postpartum Depression

Investigating Risk Factors for Postpartum Depression

The First Baby Study at Penn State College of Medicine includes more than 3 000 women in Pennsylvania having their first baby.

Irritability in Recovered Bipolar Disorder Patients Linked to Greater Morbidity, Depression Recurrence

Irritability in Recovered Bipolar Disorder Patients Linked to Greater Morbidity, Depression Recurrence

Delayed depressive recovery occurred more in depressed patients with current irritability.

Associations Between Comorbid Cigarette, Alcohol, and Marijuana Use and Psychopathology

Associations Between Comorbid Cigarette, Alcohol, and Marijuana Use and Psychopathology

Understanding distinct patterns of comorbid substance use may be more relevant to prevention and treatment than focusing on one individual substance.

Cognitive Function in Depression: The Role of Melancholic Features

Cognitive Function in Depression: The Role of Melancholic Features

Individuals diagnosed with melancholic major depressive disorder presented with more severe symptoms of depression compared with persons with non-melancholic depression.

ACC Activation to Reward Predicts Response to Psychotherapy for MDD

ACC Activation to Reward Predicts Response to Psychotherapy for MDD

Sustained anterior cingulate cortex activation during rewarding events predicted better treatment response to Behavioral Activation Treatment for Depression.

Meta-Analysis: Depression Common in Patients Discharged From ICU

Meta-Analysis: Depression Common in Patients Discharged From ICU

Risk highest among patients with psych symptoms pre-ICU/psych distress symptoms while in ICU

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

Bipolar disorder and schizophrenia are characterized by significant genetic overlap, as well as significant clinical presentation overlap.

Intergenerational Transmission of Risk for Depression

Intergenerational Transmission of Risk for Depression

Grandchildren with both a depressed parent and depressed grandparent were at highest risk for MDD.

Psychotropic Drug Indications

Drug comparisons for mood disorders such as bipolar disorder, major depressive disorder, treatment resistant depression, premenstrual dysphoric disorder, and others.

Optimal SF-36 Threshold to Screen for MDD, GAD in RA

Optimal SF-36 Threshold to Screen for MDD, GAD in RA

An analysis of the SF-36 health survey found that the survey can accurately determine the presence of psychological disorders in patients with RA, and suggests that a threshold of ≤38 on the mental component summary score may be optimal to screen for these disorders.

Can Depression Artificially Inflate Rheumatoid Arthritis DAS28 Scores?

Can Depression Artificially Inflate Rheumatoid Arthritis DAS28 Scores?

Inflated DAS28 may indicate significant psychological morbidity and related non-inflammatory pain, rather than true rheumatoid arthritis disease activity.

Neural Correlates of Emotion Regulation in Adolescence Following Childhood Adversity

Neural Correlates of Emotion Regulation in Adolescence Following Childhood Adversity

Childhood is a critical developmental period in the brain's response to traumatic stress such as family adversity.

Augmentation With Antidepressants in Schizophrenia Treatment Appears Safe and Efficacious

Augmentation With Antidepressants in Schizophrenia Treatment Appears Safe and Efficacious

In terms of depressive and negative symptoms, in the present meta-analysis, researchers estimate that 1 in 9 patients with schizophrenia will improve with add-on antidepressants.

Identifying Depression: How Accurate is the PHQ-2?

Identifying Depression: How Accurate is the PHQ-2?

The accuracy of the PHQ-2 in identifying major depression is lower than originally thought.

Following an Episode of Mania, Adults With Bipolar Disorder at Equal Risk for Depression or Anxiety

Following an Episode of Mania, Adults With Bipolar Disorder at Equal Risk for Depression or Anxiety

Bipolar disorder (BD) is typically characterized by recurrent episodes of mania and depression, but the connection between BD and anxiety needs to be considered.

Arthritis Raises Suicide Risk

Arthritis Raises Suicide Risk

The findings could have important clinical implications in the treatment of patients with arthritis.

The Long-Term Mental Health Outcomes of Adolescent Chronic Pain

The Long-Term Mental Health Outcomes of Adolescent Chronic Pain

Adolescents who experience chronic pain have higher prevalence of anxiety and depressive symptoms in adulthood.

What Neuroimaging Can Teach us About Depression

What Neuroimaging Can Teach us About Depression

Neuroimaging studies have shown several neurophysiological substrates for depression: An overview by Theodore Henderson, MD, PhD.

CDC Report: Jobs With the Highest Suicide Rates

CDC Report: Jobs With the Highest Suicide Rates

Events that happen in childhood and adolescence can predispose individuals to suicidal behavior.

Do Adjunctive Neutraceuticals Help Relieve Depression?

Do Adjunctive Neutraceuticals Help Relieve Depression?

Augmentation and combination approaches with pharmaceuticals are often used in clinical practice.

Depression Associated With COPD Meds Nonadherence

Depression Associated With COPD Meds Nonadherence

Interventions are needed to enhance adherence to prescribed medications, especially in older adults experiencing new episodes of depression.

AAP Urges Pediatricians to Screen Teens for Suicide Risk Factors

AAP Urges Pediatricians to Screen Teens for Suicide Risk Factors

Identifying environmental factors that put teens at risk for suicidal behavior is crucial.

Peripheral Inflammatory Markers Are Associated With Psychomotor Retardation in Major Depressive Disorder

Peripheral Inflammatory Markers Are Associated With Psychomotor Retardation in Major Depressive Disorder

Psychomotor retardation is associated with poor response to antidepressant treatment.

Epigenetic Modifications Associated with Low SES May Influence Depression Risk

Epigenetic Modifications Associated with Low SES May Influence Depression Risk

Socioeconomic status was the only environmental stressor that predicted an increase in SLC6A4 proximal promoter methylation.

Enduring Depression Linked to Increased Coronary Artery Calcification Among Women

Enduring Depression Linked to Increased Coronary Artery Calcification Among Women

Major depressive disorder is a highly disabling condition that affects nearly 15 million American adults in a given year.

Off-Label Prescription of Antidepressants on the Rise

Off-Label Prescription of Antidepressants on the Rise

The most common off-label uses were for insomnia (10.2%) and pain (6.1%).

Genetic Variants May Account for Poorer ECT Response in Treatment-Resistant Patients

Genetic Variants May Account for Poorer ECT Response in Treatment-Resistant Patients

Polymorphisms of the GRIK4 gene modulate the response to electroconvulsive therapy.

Psilocybin Effective for Treatment-Resistant Depression

Psilocybin Effective for Treatment-Resistant Depression

This small-scale feasibility study did not include a control group.

Abnormal Habenula Activation Profile in Major Depression

Abnormal Habenula Activation Profile in Major Depression

Aversive conditioned stimulus-elicited habenula response decreased in individuals diagnosed with major depression.

Stress-Induced Depressive-Like Symptoms Controlled by Networks of Genes

Stress-Induced Depressive-Like Symptoms Controlled by Networks of Genes

Manipulating gene networks across distinct brain regions in mice affects susceptibility or resilience to depression-like behavior.

Brain Cortical Thinning and Surface Area Reductions in Major Depressive Disorder

Brain Cortical Thinning and Surface Area Reductions in Major Depressive Disorder

Age-dependent structural brain abnormalities identified in adolescents and adults with major depressive disorder.

Restricting Calories Improves Health and Mood in Non-Obese

Restricting Calories Improves Health and Mood in Non-Obese

Those in the calorie cutting group said their sleep and relationships also improved.

Importance of Perceived Control in Treating Pain, Depression

Importance of Perceived Control in Treating Pain, Depression

Clinicians should focus on treating patients' pain and psychological conditions together.

Antidepressant Bupropion Linked To Less Weight Gain

Antidepressant Bupropion Linked To Less Weight Gain

Having more information on the long-term impact of antidepressants on weight could reduce the risk of weight-related morbidity for a large population of adults with depression.

Depression May Affect Migraine Treatment Response

Depression May Affect Migraine Treatment Response

Depression is one of many factors that can predict an inadequate treatment response in patients with episodic migraine.

Cognitive Function's Importance to Recovery in Depression

Cognitive Function's Importance to Recovery in Depression

Patients commonly report inter-episodic cognitive complaints during the "remitted" phases of depression that negatively affect their ability to engage in more cognitively demanding activities.

Diabetes Weight Loss Diets Improve Mood, Depression

Diabetes Weight Loss Diets Improve Mood, Depression

How does a high carbohydrate or low carbohydrate weight loss diet affect depression in type 2 diabetes?

Can Effectively Treating Depression Reduce Cardiovascular Risk?

Can Effectively Treating Depression Reduce Cardiovascular Risk?

The risk of cardiovascular disease as a person's depression improves or worsens has largely remained unknown.

Ankylosing Spondylitis Increases Risk of Depressive Disorders

Ankylosing Spondylitis Increases Risk of Depressive Disorders

Research has found that patients with AS have an increased risk of developing certain depressive disorders following their diagnosis.

SSRIs Found Not To Increase Risk of Cardiac Events in Depression

SSRIs Found Not To Increase Risk of Cardiac Events in Depression

Neither a specific antidepressant class nor individual drugs had any influence on the risk of stroke or transient ischemic attack over all of follow-up.

Coffee, Caffeine May Be Linked With Decreased Depression Risk

Coffee, Caffeine May Be Linked With Decreased Depression Risk

Although researchers are not certain about the mechanisms driving the link between depression and coffee or caffeine consumption, several potential explanations have emerged.

Ketamine May Provide Lasting Relief From Depression

Ketamine May Provide Lasting Relief From Depression

Treatment gives infusions of ketamine no more than once per week.

Obesity Linked to Greater Depression Odds in College-Educated Women

Obesity Linked to Greater Depression Odds in College-Educated Women

Modestly obese women who were educated were almost twice as likely to have depression than their normal-weight peers.

The Benefits and Consequences of Legalized Marijuana

The Benefits and Consequences of Legalized Marijuana

Questions remain as to whether botanically-derived marijuana offers clinical benefit over pharmaceutical-grade THC, its active ingredient.

Care Management Processes Lacking in Primary Care for Depression

Care Management Processes Lacking in Primary Care for Depression

Significantly less use of care management processes for depression compared with asthma, congestive heart failure, or diabetes.

SSRI May Improve Neurocognitive Disorder in HIV Patients

SSRI May Improve Neurocognitive Disorder in HIV Patients

Paroxetine use improved cognitive impairment and reduced inflammation in HIV patients.

Depression Risk Elevated in TBI Patients with High Cholesterol

Depression Risk Elevated in TBI Patients with High Cholesterol

Study suggests statins may play a role in the development of new-onset depression.

Treating Patients Who Have Experienced Stillbirth

Treating Patients Who Have Experienced Stillbirth

Stillbirth is associated with suicidal ideation, depression, anxiety and other manifestations of post-traumatic stress disorder.

Strong Link Found Between Postpartum Depression and Suicide Risk

Strong Link Found Between Postpartum Depression and Suicide Risk

Study is the first to compare suicide risk of new mothers with postpartum disorder to other categories of women.

Novel Therapy Leads to Significant Reduction in Suicide Re-Attempts

Novel Therapy Leads to Significant Reduction in Suicide Re-Attempts

The Attempted Suicide Short Intervention Program is a low-cost psychiatric intervention for patients in a hospital after an attempt.

Mobile Phone Addiction in Students Linked to Anxiety, Depression

Mobile Phone Addiction in Students Linked to Anxiety, Depression

Students with self-described addictive behaviors toward smartphones or the Internet scored higher on anxiety and depression scales.

Chronic Stress Impacts Immune System, Inhibits Memory

Chronic Stress Impacts Immune System, Inhibits Memory

Mice repeatedly exposed to an aggressive intruder had a difficult time remembering locations in a previously mastered maze.

Therapists' Fear of Borderline Personality Disorder Persists

Therapists' Fear of Borderline Personality Disorder Persists

Many clinicians are apprehensive about the risk associated with symptoms of BPD, such as self-harm and suicidal behavior.

Pediatricians Miss Opportunities for Maternal Depression Screenings

Pediatricians Miss Opportunities for Maternal Depression Screenings

Only 44% of pediatricians ask mothers during child visits about maternal depression.

Openly Transgender Youth Do Not Have Higher Depression Rates

Openly Transgender Youth Do Not Have Higher Depression Rates

Transgender children who have socially transitioned have only minimal elevations in anxiety.

Post Stem Cell Transplant, Depression and PTSD Common

Post Stem Cell Transplant, Depression and PTSD Common

Decline in QOL and increase in depressive symptoms during hospitalization predict six-month outcomes.

Attention Shifting Game Could Help Depression in Adolescents

Attention Shifting Game Could Help Depression in Adolescents

Attention bias modification is intended to shift one's attention away from negative stimuli.

High Rate Of Spouses Who Share Psychiatric Disorders

High Rate Of Spouses Who Share Psychiatric Disorders

The research represents the first general population study of assortative mating in psychiatric disorders.

Improvements Needed in Treating Veterans With PTSD, Depression

Improvements Needed in Treating Veterans With PTSD, Depression

The number and timing of follow-up psychotherapy visits may be inadequate to deliver evidence-based psychotherapy.

Children With Chronic Headaches May Be at Higher Risk of Mental Illness

Children With Chronic Headaches May Be at Higher Risk of Mental Illness

Children and teens with chronic headache pain and suspected of having an underlying psychiatric condition should be screened for anxiety and depression.

USPSTF: Depression Screening Only For Children Aged 12 to 18 Years Old

USPSTF: Depression Screening Only For Children Aged 12 to 18 Years Old

Insufficient evidence to recommend screening for children aged 11 and younger.

Botox Helps Ease Anxiety, Depression in Patients With Skin Condition

Botox Helps Ease Anxiety, Depression in Patients With Skin Condition

Reductions in sweat-related health problems, anxiety and depression, symptom severity.

How Nutritional Interventions Can Help Improve Mental Illnesses

How Nutritional Interventions Can Help Improve Mental Illnesses

Although not usually considered as part of primary treatment, nutrition addresses the crucial link between food and brain functioning.

Using Marijuana Doesn't Boost Anxiety, Mood Disorders Risk

Using Marijuana Doesn't Boost Anxiety, Mood Disorders Risk

Smoking pot, however, is significantly associated with any substance use, alcohol use, drug use disorders.

Significant Treatment Gaps Exist for Depression Patients

Significant Treatment Gaps Exist for Depression Patients

Results from a new survey suggest that significant gaps exist in the treatment for adults in the US with major depressive disorder.

Bullied Preemies At Greater Risk for Mental Illness as Adults

Bullied Preemies At Greater Risk for Mental Illness as Adults

Preemies may possess elevated levels of characteristics that put them at risk for peer victimization, including more anxiety and depression.

Can New Class of Mood Disorder Drugs Also Treat Chronic Pain?

Can New Class of Mood Disorder Drugs Also Treat Chronic Pain?

New research suggests that a group of drugs being developed for mood disorders could also relieve chronic pain.

Women, Chronic Psychiatric Patients Seek Out Assisted Suicide the Most

Women, Chronic Psychiatric Patients Seek Out Assisted Suicide the Most

Patients are usually women; most have chronic, severe conditions with histories of suicide.

Antidepressants May Double Risk of Suicide, Aggression In Adolescents

Antidepressants May Double Risk of Suicide, Aggression In Adolescents

The odds ratios for children and adolescents were 2.39 for suicidality, 2.79 for aggression, and 2.15 for akathisia.

Animal-Assisted Therapy Linked to Psychological Benefits

Animal-Assisted Therapy Linked to Psychological Benefits

Recent studies have shown that AAT may improve outcomes and reduce various symptoms for people with depression, anxiety, dementia.

SSRI Use Associated With Higher Risk of Postpartum Hemorrhage

SSRI Use Associated With Higher Risk of Postpartum Hemorrhage

Risk up with exposure to serotonin-norepinephrine reuptake inhibitors in late pregnancy.

Suicide Risk Increased 3-Fold After Concussion

Suicide Risk Increased 3-Fold After Concussion

The long-term risk of suicide is increased, particularly after concussions on weekends.

CBT, Medication Have Same Efficacy for Treating Depression

CBT, Medication Have Same Efficacy for Treating Depression

For adults, similar efficacy for cognitive behavioral therapy and antidepressants.

Concussions: A Growing Psychiatric Epidemic

Concussions: A Growing Psychiatric Epidemic

Until more effort is put into preventing injury in the first place, psychiatrists will likely continue to be key players in the game.

Suicide Risk May Be Increased In Those Impacted By Suicide

Suicide Risk May Be Increased In Those Impacted By Suicide

Those bereaved by suicide were 65% more likely to attempt suicide than those bereaved by natural causes.

Parental Depression Linked to Poorer Academics in Children

Parental Depression Linked to Poorer Academics in Children

Parental depression was associated with almost half a decile lower ranking in children's final grades.

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