Depressive Disorder News Archive
The authors noted a potential for a complex and dynamic relationship between depression and functional outcomes in multiple sclerosis , with greater dysfunction possibly increasing levels of depression.
Pain conditions may largely be underrecognized contributors to the overdose epidemic.
Researchers conducted a double-blind crossover study in adults with treatment-resistant depression to determine the involvement of the opioid system in ketamine's antidepressant effects.
Researchers working with a population of veterans found that the healthcare utilization costs of telehealth services were significantly cheaper compared with in-person visits, with only a relatively small difference in quality of life.
These findings suggest an increased risk for postpartum depressive symptoms in mothers with gestational diabetes, independent of depressive symptomatology during pregnancy.
This research suggests that combination therapy not only produces greater proportional response in depression symptoms but that it is also effective in a broader range of individuals.
Use of serotonin reuptake inhibitors for maternal depression may increase the risk for low birth weight in children.
Results showed a significant change in depression severity with a mean MADRS reduction of 18.45 and a response rate of 86.7%.
Researchers found 3 distinct subgroups of patients in relation to suicidal ideation and effects of ketamine, with one group's suicidal ideation completely eliminated and the other group's improvement independent of depressed mood.
Chronic neuropathic pain has a large impact on quality of life and often causes or increases depressive symptoms for both men and women.
These adolescents may have delayed white matter maturation or early alterations in tracts connecting the anterior corpus callosum to the anterior cingulate cortex, which may carry a high risk for transition to depression.
These data support the clinical use of combinatorial pharmacogenetics for patients with major depressive disorder.
The high-risk class was associated with risk factors such as complications after birth, elevated depressive symptoms during pregnancy, and previous mental illness.
The first-ever guidelines for the evaluation and treatment of perimenopausal depression have been published.
The NDA includes five Phase 3 studies in patients with treatment-resistant depression: 3 short-term studies, 1 withdrawal maintenance of effect study, and 1 long-term safety study.
Researchers are conducting a trial to determine whether 25 or 50 psychotherapy sessions in a year will be more effective at reducing symptoms of depression in patients with personality disorders.
This study suggests that parental spirituality may affect offspring mental health, particularly regarding suicidal behaviors.
These data suggest that lurasidone is effective in treating major depressive disorder with manic features without introducing sexual dysfunction.
The trial will be a Phase 2b dose-ranging study (N=216) with patients from 12-15 research centers across Europe and North America.
The authors argue that identifying and treating sleep disorders during early stages may have a positive impact on outcomes in psychiatric patients.
Despite the associated risk for death and cognitive decline, "off-label" prescribing of antipsychotics in patients with dementia has increased.
These data indicate that cortisol levels may contribute to the cognitive decline observed in elderly adults with late-life depression.
Deep Transcranial Magnetic Stimulation Combined With SSRIs Possibly Effective for Treatment-Resistant Depression
These results suggest that deep transcranial magnetic stimulation combined with selective serotonin reuptake inhibitors may be effective in assisting patients with treatment-resistant depression.
Physical exercise is associated with self-reported mental health burden in the past month.
Demographic characteristics predictive of transfer to specialized services included younger age and higher education level.
There is sufficient evidence to suggest that physiology and culture underlie some of the variation in how depression and anxiety symptoms can manifest.
Patients with dementia had an increased prevalence of major depressive disorder.
Further assessment of this relationship and its underlying mechanisms may help clinicians anticipate the likelihood of patients' adherence to risk-reducing habits.
Many Americans aged 35 and older are not being assessed for depression.
Abstinence in midlife and consumption of more than 14 units of alcohol per week are associated with increased risk of dementia.
These data indicate that paternal depression is a substantial burden for the parent population that warrants research into appropriate intervention methods.
Appetitive Symptoms, Fluoxetine, and Light Therapy: Predicting Treatment Response for Nonseasonal Major Depression
Researchers examined whether more severe appetitive symptoms predicted a positive response to light therapy.
The GDS-15 uses short sentences and a yes/no format, which is easier for patients who are struggling with depression, fatigue, or cognitive impairment to tolerate.
A combination of factors may have been responsible for the association between parental depression and increased healthcare visits in their children, including shared genetic risks.
Results showed an increased risk of bleeding with SRIs by 1.16-2.36 times with an even higher 3.17- to 10.9-fold risk with concomitant NSAIDs.
Depression is common in patients with axSpA and is associated with more severe disease activity and functional impairment.
These data suggest that marijuana use, particularly non-medical use, is associated with poorer depression and anxiety outcomes in psychiatric patients.
These data suggest a neurologic basis for the relationship between sleep quality and depressive symptoms, even among patients with no clinical diagnosis of depression.
Depression is associated with poorer outcomes in ACS and these findings suggest that this course of treatment may improve long-term major adverse cardiac event outcomes.
An intervention targeting depression in very young children can be effective in community settings.
These data substantiate claims that certain neuroinflammatory biomarkers may predict depression symptoms or severity and could be useful in developing diagnostic and treatment strategies.
Researchers believe this therapy shows potential as a brain-based approach for correcting cortical physiologic deficits in this population.
The researchers noted that these findings highlight the complexity of obesity as a disease that shares a common etiology with some psychiatric and addictive disorders.
The results showed that women with antenatal MDD have abnormal stress-related inflammation and cortisol levels, a shorter gestational length, neonates with suboptimal neurobehavioral function, and their 1-year-old infants have increased cortisol reactivity to stress.
Findings revealed that women's self-reported affective instability predicted depressive symptoms over time.
Prenatal depression may be more common today among young pregnant women than among women in their mothers' generation.
Adults with depressive symptoms and apathy in middle and late life were at a higher risk for conversion to mild cognitive impairment (MCI) and dementia.
An investigational treatment for major depressive disorder, AGN-241751, has been granted Fast Track designation by the FDA.
Problem-solving education is effective at preventing depressive symptoms among low-income mothers.
These results challenge existing conceptions that omega-3 fatty acids may be effective in treating adolescent major depressive disorder.
Bereaved children were more likely to experience depression, and children who lost a parent before the age of 12 were more likely to experience depression within the first 2 years.
While the findings do not warrant a change in current prescribing practices, researchers advocate monitoring at-risk children in light of the increased use of antidepressants during pregnancy.
Research has suggested a number of possible relationships with lipophilic statins, including a protective phenomenon against depression and higher risk for dementia, although these associations remain controversial.Research has suggested a number of possible relationships with lipophilic statins, including a protective phenomenon against depression and higher risk for dementia, although these associations remain controversial.
On the basis of these findings, researchers recommended that "[f]atigue should be evaluated whenever there is clinical suspicion of overlap syndrome."
Children in the waiting list group exhibited significantly worse impairments on the Preschool Feelings Checklist at the study's end, but children who completed the therapy showed improvements in emotion regulation and guilt processing.
These results demonstrate the importance of midlife fitness to prevent depression and subsequent CVD mortality in older age.
This research provides further support to compelling data linking inflammation and depression.
This study supports the effects of close clinical observation and the use of combined treatment interventions including repetitive transcranial magnetic stimulation for achieving remission in veterans with treatment-resistant depression.
Investigators note that depression should be evaluated and treated in patients with multiple sclerosis and may hinder balance rehabilitation.
Patients with these cardiovascular diseases would benefit from early psychiatric help.
These data may be useful to clinicians in gaining insight on the potential risks of cannabis use among their patients with anxiety or mood disorders.
Technology-Enhanced Intervention in the ED Appears Promising for Reducing Underage Drinking, Consequences
This intervention provides flexibility in the clinical setting, allowing for therapist delivery when staff is available and computer delivery when staff resources are not available.
Clinicians may find these data useful in treating patients with major depressive disorder and an inadequate response to antidepressant treatment alone.
It may be important to increase awareness of avoiding negative social media encounters to reduce the risk for depressive symptoms.
The researchers believe this study is the first to detect a statistically significant, unexpected inverse association between efavirenz use and depression.
The age association remained significant after additional adjustments for clinical and social factors such as loneliness and pain. As such, age-specific factors cannot alone explain the poorer MDD course associated with older age.
Investigators sought to determine the frequency of major depressive disorder in patients in epilepsy clinics.
Carefully assessing cognitive performance using a screening test to detect visuospatial/executive, attention, and memory dysfunction in patients with migraine.
An estimated 37.2% of people in the United States use medications that have an adverse effect of depression.
Preliminary generalizations point toward the potential therapeutic efficacy of targeting loneliness and social support for patients.
The notion that abortion harms women's mental health may be misinformed and should be re-examined according to scientific data such as these.
This study was prompted by an ongoing shortage of injectable caffeine sodium benzoate in the United States from 2011 to 2017.
These analyses may serve clinicians in addressing potential psychiatric obstacles in patients undergoing fertility treatments.
These data may be helpful in developing targeted interventions for women at risk for postpartum depression.
As this and previous research on dose increase strategies have produced inconsistent findings, the researchers recommended clinicians consider other responses to antidepressant treatment failure, at least for selective serotonin reuptake inhibitors.
These data could be useful to clinicians and patients alike in selecting the proper treatment method.
The Janssen Pharmaceutical Companies of Johnson & Johnson have announced the results of 2 long-term phase 3 clinical trials examining esketamine nasal spray in patients with treatment-resistant depression.
Among men, those with active major depression were less likely to have a partner achieve conception.
Examining the Relationship Between Childhood Anxiety, Depression and Risk for Cardiovascular Disease
The potential plasticity of the cardiovascular system during childhood may explain the lack of significant relationship between depression and anxiety symptomatology and CVD risk in this study population.
Routine assessments of these markers should be conducted before and during treatment as they may inform prognoses.
The relationship between pain and cognitive dysfunction was explained by sleep disturbance and depressive symptoms.
Carbamazepine, in particular, was associated with lower hazards for depression and anxiety in secondary analyses.
Active major depression in the male partner may lower the likelihood of pregnancy.
The erythematotelangiectatic, papulopustular, phymatous, and ocular forms of rosacea can lead to psychological distress.
A substantial proportion of these individuals diagnosed with HIV, psychiatric disorders, and substance use disorders are out of care and urgently require intervention.
These findings suggest a strong association between greater depressive symptoms and markers of brain aging as well as impaired episodic memory.
Widespread use of antidepressants may be contributing to long-term increased risk for weight gain.
When assessing risk for postpartum episodes, clinicians should inquire about family history of psychiatric disorders broadly and not limit discussion to postpartum psychiatric disorders or psychiatric disorders in female relatives.
Baseline depressive symptoms were associated with pain and disability in adolescents with juvenile idiopathic arthritis.
Sedentary behavior is closely linked to a more articulated pattern of psychological variables, largely influenced by sex-related differences in the individual psychological characteristics.
Gender may not influence vulnerability for developing new-onset depression during interferon-alpha therapy.
A placebo-controlled study could further clarify these results and possibly strengthen the case for antidepressant treatment for depression in vascular cognitive impairment.
Despite the widespread use of antidepressants for treating insomnia, the evidence for their effectiveness remains limited.
Diagnoses of major depression have increased since 2013, particularly among adolescents and millennials.
This study had a sample size large enough to assess the effect of circadian disruption on mental health disorders, and was the first to objectively measure patterns of rest and activity (using accelerometers).
Mental health problems are 1 of the most important reasons for failing to engage in long-term control of HIV.
Multimarker inflammatory biosignatures are expected to facilitate diagnosis and predict treatment outcomes for various central nervous system disorders, particularly Alzheimer disease and major depressive disorder.
Investigators assessed whether depressive symptoms during and after pregnancy were associated with neurodevelopmental disadvantages in children.
Clinicians should take depression into careful consideration when treating patients with Alzheimer dementia, as the two conditions combined may predispose patients to cardiovascular disease more than either condition alone.
The average MADRS-10 scores decreased from baseline, and this decrease was maintained at the end of the study.
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