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DEPOCYT
Leukemias, lymphomas, and other hematologic cancers
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Drug Name:

DEPOCYT Rx

Generic Name and Formulations:
Cytarabine 50mg/vial; liposomal suspension for intrathecal administration; preservative-free.

Company:
Sigma-Tau Pharmaceuticals, Inc.

Therapeutic Use:

Indications for DEPOCYT:

Intrathecal treatment of lymphomatous meningitis.

Adult:

See literature. Give intrathecally over 1–5 minutes. Administer dexamethasone 4mg twice daily for 5 days with each cycle of treatment. Induction: 50mg every 14 days for 2 doses (weeks 1 and 3). Consolidation: 50mg every 14 days for 3 doses (weeks 5, 7 and 9) followed by 1 additional dose at week 13. Maintenance: 50mg every 28 days for 4 doses (weeks 17, 21, 25 and 29). Reduce dose to 25mg if neurotoxicity develops and discontinue if it persists.

Children:

Not recommended.

Contraindications:

Active meningeal infection.

Warnings/Precautions:

Chemical arachnoiditis; reduce symptoms with dexamethasone. Previous irradiation, cytotoxic chemotherapy. Monitor blood counts and for development of neurotoxicity. Renal and hepatic impairment. Pregnancy (Cat.D); avoid use. Nursing mothers: not recommended.

Interactions:

Increased risk of neurotoxicity with concomitant cranial/spinal irradiation or other intrathecal antineoplastics.

Pharmacological Class:

Antimetabolite.

Adverse Reactions:

See literature. Arachnoiditis, GI upset, headache, fever, neurological toxicity (myelopathy), hydrocephalus, elevated CSF protein and WBC, weakness, back pain, insomnia, blurred vision, anaphylactic reactions; others.

How Supplied:

Single-use vials (5mL)—1

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