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Cyclophosphamide
Breast cancer
CNS cancers
Eye cancer
Gynecologic cancers
Leukemias, lymphomas, and other hematologic cancers
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Drug Name:

Cyclophosphamide Rx

Generic Name and Formulations:
Cyclophosphamide 25mg, 50mg; tabs.

Company:
Various generic manufacturers

Therapeutic Use:

Indications for Cyclophosphamide:

Carcinoma of the breast.

Adult:

Initial and maintenance: 1–5mg/kg/day.

Children:

See literature.

Contraindications:

Severe bone marrow depression.

Warnings/Precautions:

Leukopenia. Thrombocytopenia. Tumor cell infiltration of bone marrow. Previous X-ray therapy or cytotoxic chemotherapy. Impaired renal or hepatic function. Infections. Adrenalectomy. General anesthesia within 10 days of therapy. Monitor hematologic profile (esp. neutrophils and platelets). Obtain urine sample (monitor for hemorrhagic cystitis); maintain adequate hydration. May interfere with wound healing. Elderly. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions:

Potentiated by phenobarbital. Potentiates other myelosuppressives, radiotherapy, succinylcholine. May potentiate doxorubicin-induced cardiotoxicity.

See Also:

CYTOXAN INJECTION

Pharmacological Class:

Alkylating agent.

Adverse Reactions:

GI upset, alopecia, leukopenia, infections, thrombocytopenia, anemia, hemorrhagic cystitis (discontinue if occurs), renal tubular necrosis, interstitial pulmonary fibrosis, gonadal toxicity (amenorrhea, infertility), anaphylactic reactions.

Note:

Tabs formerly known under the brand name Cytoxan.

How Supplied:

Tabs—contact supplier
Single-use vial—1

Indications for Cyclophosphamide:

Neuroblastoma (disseminated disease).

Adult:

Initial and maintenance: 1–5mg/kg/day.

Children:

See literature.

Contraindications:

Severe bone marrow depression.

Warnings/Precautions:

Leukopenia. Thrombocytopenia. Tumor cell infiltration of bone marrow. Previous X-ray therapy or cytotoxic chemotherapy. Impaired renal or hepatic function. Infections. Adrenalectomy. General anesthesia within 10 days of therapy. Monitor hematologic profile (esp. neutrophils and platelets). Obtain urine sample (monitor for hemorrhagic cystitis); maintain adequate hydration. May interfere with wound healing. Elderly. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions:

Potentiated by phenobarbital. Potentiates other myelosuppressives, radiotherapy, succinylcholine. May potentiate doxorubicin-induced cardiotoxicity.

See Also:

CYTOXAN INJECTION

Pharmacological Class:

Alkylating agent.

Adverse Reactions:

GI upset, alopecia, leukopenia, infections, thrombocytopenia, anemia, hemorrhagic cystitis (discontinue if occurs), renal tubular necrosis, interstitial pulmonary fibrosis, gonadal toxicity (amenorrhea, infertility), anaphylactic reactions.

Note:

Tabs formerly known under the brand name Cytoxan.

How Supplied:

Tabs—contact supplier
Single-use vial—1

Indications for Cyclophosphamide:

Retinoblastoma.

Adult:

Initial and maintenance: 1–5mg/kg/day.

Children:

See literature.

Contraindications:

Severe bone marrow depression.

Warnings/Precautions:

Leukopenia. Thrombocytopenia. Tumor cell infiltration of bone marrow. Previous X-ray therapy or cytotoxic chemotherapy. Impaired renal or hepatic function. Infections. Adrenalectomy. General anesthesia within 10 days of therapy. Monitor hematologic profile (esp. neutrophils and platelets). Obtain urine sample (monitor for hemorrhagic cystitis); maintain adequate hydration. May interfere with wound healing. Elderly. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions:

Potentiated by phenobarbital. Potentiates other myelosuppressives, radiotherapy, succinylcholine. May potentiate doxorubicin-induced cardiotoxicity.

See Also:

CYTOXAN INJECTION

Pharmacological Class:

Alkylating agent.

Adverse Reactions:

GI upset, alopecia, leukopenia, infections, thrombocytopenia, anemia, hemorrhagic cystitis (discontinue if occurs), renal tubular necrosis, interstitial pulmonary fibrosis, gonadal toxicity (amenorrhea, infertility), anaphylactic reactions.

Note:

Tabs formerly known under the brand name Cytoxan.

How Supplied:

Tabs—contact supplier
Single-use vial—1

Indications for Cyclophosphamide:

Adenocarcinoma of the ovary.

Adult:

Initial and maintenance: 1–5mg/kg/day.

Children:

See literature.

Contraindications:

Severe bone marrow depression.

Warnings/Precautions:

Leukopenia. Thrombocytopenia. Tumor cell infiltration of bone marrow. Previous X-ray therapy or cytotoxic chemotherapy. Impaired renal or hepatic function. Infections. Adrenalectomy. General anesthesia within 10 days of therapy. Monitor hematologic profile (esp. neutrophils and platelets). Obtain urine sample (monitor for hemorrhagic cystitis); maintain adequate hydration. May interfere with wound healing. Elderly. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions:

Potentiated by phenobarbital. Potentiates other myelosuppressives, radiotherapy, succinylcholine. May potentiate doxorubicin-induced cardiotoxicity.

See Also:

CYTOXAN INJECTION

Pharmacological Class:

Alkylating agent.

Adverse Reactions:

GI upset, alopecia, leukopenia, infections, thrombocytopenia, anemia, hemorrhagic cystitis (discontinue if occurs), renal tubular necrosis, interstitial pulmonary fibrosis, gonadal toxicity (amenorrhea, infertility), anaphylactic reactions.

Note:

Tabs formerly known under the brand name Cytoxan.

How Supplied:

Tabs—contact supplier
Single-use vial—1

Indications for Cyclophosphamide:

Malignant lymphomas (Stages III and IV of the Ann Arbor staging system), Hodgkin's disease, lymphocytic lymphoma (nodular or diffuse), mixed-cell type lymphoma, histiocytic lymphoma, Burkitt's lymphoma. Multiple myeloma. Leukemias: chronic lymphocytic leukemia, chronic granulocytic leukemia (it is usually ineffective in acute blastic crisis), acute myelogenous and monocytic leukemia, acute lymphoblastic (stem-cell) leukemia in children (cyclophosphamide given during remission is effective in prolonging its duration). Mycosis fungoides (advanced disease).

Adult:

Initial and maintenance: 1–5mg/kg/day.

Children:

See literature.

Contraindications:

Severe bone marrow depression.

Warnings/Precautions:

Leukopenia. Thrombocytopenia. Tumor cell infiltration of bone marrow. Previous X-ray therapy or cytotoxic chemotherapy. Impaired renal or hepatic function. Infections. Adrenalectomy. General anesthesia within 10 days of therapy. Monitor hematologic profile (esp. neutrophils and platelets). Obtain urine sample (monitor for hemorrhagic cystitis); maintain adequate hydration. May interfere with wound healing. Elderly. Pregnancy (Cat.D). Nursing mothers: not recommended.

Interactions:

Potentiated by phenobarbital. Potentiates other myelosuppressives, radiotherapy, succinylcholine. May potentiate doxorubicin-induced cardiotoxicity.

See Also:

CYTOXAN INJECTION

Pharmacological Class:

Alkylating agent.

Adverse Reactions:

GI upset, alopecia, leukopenia, infections, thrombocytopenia, anemia, hemorrhagic cystitis (discontinue if occurs), renal tubular necrosis, interstitial pulmonary fibrosis, gonadal toxicity (amenorrhea, infertility), anaphylactic reactions.

Note:

Tabs formerly known under the brand name Cytoxan.

How Supplied:

Tabs—contact supplier
Single-use vial—1

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