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COMBIVIR
Viral infections
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Drug Name:

COMBIVIR Rx

Generic Name and Formulations:
Lamivudine 150mg, zidovudine 300mg; scored tabs.

Company:
GlaxoSmithKline

Therapeutic Use:

Indications for COMBIVIR:

HIV-1 infection.

Adults and Children:

<30kg: not recommended. ≥30kg: 1 tab twice daily. Hepatic or renal impairment (CrCl <50mL/min): not recommended; use individual components.

Warnings/Precautions:

Risk of hematologic toxicity/bone marrow suppression; monitor CBCs esp. in advanced HIV-1 disease; interrupt dose if anemia or neutropenia occurs. Myopathy with prolonged zidovudine use. Suspend if lactic acidosis or hepatotoxicity (eg, hepatomegaly, steatosis) occurs. Not for treating hepatitis B; monitor patients co-infected with HBV for at least several months after stopping treatment (discontinuing may exacerbate HBV infection). History of pancreatitis. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

See full labeling. Concomitant stavudine, doxorubicin, ribavirin, emtricitabine, other forms of lamivudine or zidovudine: not recommended. Increased hematologic toxicity with ganciclovir, interferon alpha, other bone marrow suppressants or cytotoxic drugs. TMP/SMX, nelfinavir may potentiate lamivudine. Atovaquone, clarithromycin, fluconazole, methadone, nelfinavir, probenecid, rifampin, ritonavir, valproic acid may affect zidovudine levels; monitor. Monitor for treatment-associated toxicities (eg, hepatic decompensation) with interferon-alpha with or without ribavirin.

Pharmacological Class:

Nucleoside analogues (reverse transcriptase inhibitors).

Adverse Reactions:

Headache, nausea, malaise, fatigue, nasal symptoms, diarrhea, cough; neutropenia, anemia, lactic acidosis, severe hepatomegaly with steatosis, fat redistribution, myopathy, myositis, immune reconstitution syndrome, post-treatment exacerbation of hepatitis B, pancreatitis (discontinue if occurs).

Note:

Register pregnant patients exposed to lamivudine by calling (800) 258-4263.

How Supplied:

Tabs—60

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