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CIPRO XR
Bacterial infections
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Drug Name:

CIPRO XR Rx

Generic Name and Formulations:
Ciprofloxacin (as HCl and betaine) 500mg, 1000mg; ext-rel tabs.

Company:
Bayer Healthcare Pharmaceuticals Inc.

Therapeutic Use:

Indications for CIPRO XR:

Susceptible infections including UTIs, acute uncomplicated pyelonephritis. For uncomplicated UTIs: reserve for those who have no alternative treatment options.

Adult:

Swallow whole. ≥18yrs: Uncomplicated UTIs: 500mg once daily for 3 days. Complicated UTIs, acute uncomplicated pyelonephritis: 1000mg once daily for 7–14 days; renal impairment (CrCl <30mL/min): 500mg once daily for 7–14 days. Coincide dose for end of dialysis.

Children:

<18yrs: not recommended.

Contraindications:

Concomitant tizanidine.

Warnings/Precautions:

XR not interchangeable with other forms. Increased risk of disabling and potentially irreversible adverse reactions (including tendinitis/tendon rupture [esp. in patients >60yrs, or those with kidney, heart or lung transplants], peripheral neuropathy, or CNS effects); discontinue immediately if signs/symptoms occur. CNS disorders (eg, cerebral arteriosclerosis, epilepsy) that increase seizure risk. History of myasthenia gravis; avoid. Renal (except XR tabs for uncomplicated UTIs) or hepatic dysfunction: reduce dose. History of QT prolongation, ventricular arrhythmias, proarrhythmic conditions (eg, bradycardia, acute myocardial ischemia), hypokalemia, or hypomagnesemia; avoid. Discontinue at 1st sign of skin rash, jaundice, any other hypersensitivity, phototoxicity, or hepatitis. History of joint-related disorders (esp. children). Maintain adequate hydration, avoid alkaline urine to avoid crystalluria. May mask symptoms of syphilis; test for syphilis before treating gonorrhea, then follow-up after 3 months. Monitor blood, renal, hepatic function in prolonged use. Avoid excessive sun and UV light. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

See Contraindications. Potentiates hypotensive and sedative effects of tizanidine. Avoid theophylline (increases theophylline levels), duloxetine, zolpidem; oral forms with antacids, multivalent cations, calcium, iron, zinc, sucralfate, buffered forms of didanosine, other highly buffered drugs (may give ciprofloxacin 2hrs before or 6hrs after); high ciprofloxacin doses with NSAIDs (increases seizure risk). Potentiates caffeine/xanthine derivatives. Potentiated by probenecid. Severe hypoglycemia with oral antidiabetics (eg, glyburide, glimepiride). Increased serum creatinine with cyclosporine. Monitor methotrexate, oral anticoagulants (potentiation), phenytoin (variable effects), clozapine and ropinirole (potentiation). Increased risk of tendinitis/tendon rupture with corticosteroids. Caution with sildenafil, other drugs that lower seizure threshold. Increased risk of QT prolongation with Class IA or III antiarrhythmics, TCAs, macrolides, antipsychotics. Reduced absorption with omeprazole (XR).

See Also:

CIPRO

CIPRO ORAL SUSPENSION

Ciprofloxacin IV Concentrate

CIPRO IV PREMIXED

Pharmacological Class:

Quinolone.

Adverse Reactions:

Nausea, diarrhea, vomiting, headache, CNS disturbances (eg, convulsions, dizziness, nervousness, insomnia, nightmares, paranoia), rash, eosinophilia, elevated liver enzymes, photosensitivity, Stevens-Johnson syndrome, myalgia, tendinitis/tendon rupture, joint-related disorders (children), local reactions (inj); rare: increased intracranial pressure, toxic psychosis; peripheral neuropathy (may be irreversible), torsades de pointes, C. difficile-associated diarrhea.

Generic Availability:

YES

How Supplied:

Tabs—100; Oral Susp—100mL (w. graduated teaspoon); IV premixed (100mL, 200mL)—1; XR Tabs—50, 100; IV conc—contact supplier

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