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CALAN
Angina
CHF and arrhythmias
Hypertension
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Drug Name:

CALAN Rx

Generic Name and Formulations:
Verapamil HCl 40mg, 80mg+, 120mg+; tabs; +scored.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for CALAN:

Vasospastic, unstable and chronic stable angina.

Adult:

Initially 80–120mg 3 times daily, increase daily or weekly if needed; max 480mg daily. Elderly or small patients: initially 40mg 3 times daily.

Children:

<18yrs: not recommended.

Contraindications:

Severe left ventricular (LV) dysfunction or LV dysfunction treated with β-blockers. Moderate to severe heart failure. Hypotension. Cardiogenic shock. Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Atrial flutter or fibrillation and an accessory bypass tract.

Warnings/Precautions:

Control mild heart failure (eg, with digitalis, diuretics). AV conduction or neuromuscular transmission disorders. Hepatic or renal dysfunction. Monitor liver function. Hypertrophic cardiomyopathy. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiates alcohol, β-blockers, other antihypertensives, digitalis, theophylline, neuromuscular blockers, flecainide, carbamazepine, cyclosporine, lovastatin (limit to max 40mg/day), simvastatin (limit to max 10mg/day), atorvastatin (use lower doses). Potentiated by grapefruit juice. Avoid ivabradine, disopyramide; quinidine in cardiomyopathy. Potentiated by CYP3A4 inhibitors (eg, erythromycin, ritonavir); antagonized by CYP3A4 inducers (eg, phenobarbital, rifampin). Inhalation anesthetics may potentiate cardiac depression. May increase bleeding with aspirin. Monitor theophylline, lithium. Concomitant mTOR inhibitors (eg, sirolimus, temsirolimus, everolimus); consider dose reductions of both drugs. Monitor heart rate with concomitant clonidine.

Pharmacological Class:

Calcium channel blocker (CCB) (diphenylalkylamine).

Adverse Reactions:

Constipation, dizziness, nausea, hypotension, headache, edema, CHF, fatigue, dyspnea, bradycardia, AV block, rash, flushing, elevated hepatic enzymes, paralytic ileus.

How Supplied:

Tabs 40mg—100; 80mg—100, 500, 1000; 120mg—100, 1000

Indications for CALAN:

Control (with digitalis) of ventricular rate in patients with chronic atrial flutter or fibrillation. Prophylaxis of repetitive paroxysmal supraventricular tachycardia (PSVT).

Adult:

Digitalized patients with chronic atrial fibrillation: 240mg–320mg/day in 3–4 divided doses. Prophylaxis of PSVT (non-digitalized patients): 240mg–480mg/day in 3–4 divided doses.

Children:

<18yrs: not recommended.

Contraindications:

Severe left ventricular (LV) dysfunction or LV dysfunction treated with β-blockers. Moderate to severe heart failure. Hypotension. Cardiogenic shock. Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Atrial flutter or fibrillation and an accessory bypass tract.

Warnings/Precautions:

Control mild heart failure (eg, with digitalis, diuretics). AV conduction or neuromuscular transmission disorders. Hepatic or renal dysfunction. Monitor liver function. Hypertrophic cardiomyopathy. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiates alcohol, β-blockers, other antihypertensives, digitalis, theophylline, neuromuscular blockers, flecainide, carbamazepine, cyclosporine, lovastatin (limit to max 40mg/day), simvastatin (limit to max 10mg/day), atorvastatin (use lower doses). Potentiated by grapefruit juice. Avoid ivabradine, disopyramide; quinidine in cardiomyopathy. Potentiated by CYP3A4 inhibitors (eg, erythromycin, ritonavir); antagonized by CYP3A4 inducers (eg, phenobarbital, rifampin). Inhalation anesthetics may potentiate cardiac depression. May increase bleeding with aspirin. Monitor theophylline, lithium. Concomitant mTOR inhibitors (eg, sirolimus, temsirolimus, everolimus); consider dose reductions of both drugs. Monitor heart rate with concomitant clonidine.

Pharmacological Class:

Calcium channel blocker (CCB) (diphenylalkylamine).

Adverse Reactions:

Constipation, dizziness, nausea, hypotension, headache, edema, CHF, fatigue, dyspnea, bradycardia, AV block, rash, flushing, elevated hepatic enzymes, paralytic ileus.

How Supplied:

Tabs 40mg—100; 80mg—100, 500, 1000; 120mg—100, 1000

Indications for CALAN:

Hypertension.

Adult:

Initially 80mg 3 times daily; usual max 360mg/day in divided doses. Elderly or small patients: initially 40mg 3 times daily.

Children:

<18yrs: not recommended.

Contraindications:

Severe left ventricular (LV) dysfunction or LV dysfunction treated with β-blockers. Moderate to severe heart failure. Hypotension. Cardiogenic shock. Sick sinus syndrome, 2nd- or 3rd-degree AV block, unless paced. Atrial flutter or fibrillation and an accessory bypass tract.

Warnings/Precautions:

Control mild heart failure (eg, with digitalis, diuretics). AV conduction or neuromuscular transmission disorders. Hepatic or renal dysfunction. Monitor liver function. Hypertrophic cardiomyopathy. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Potentiates alcohol, β-blockers, other antihypertensives, digitalis, theophylline, neuromuscular blockers, flecainide, carbamazepine, cyclosporine, lovastatin (limit to max 40mg/day), simvastatin (limit to max 10mg/day), atorvastatin (use lower doses). Potentiated by grapefruit juice. Avoid ivabradine, disopyramide; quinidine in cardiomyopathy. Potentiated by CYP3A4 inhibitors (eg, erythromycin, ritonavir); antagonized by CYP3A4 inducers (eg, phenobarbital, rifampin). Inhalation anesthetics may potentiate cardiac depression. May increase bleeding with aspirin. Monitor theophylline, lithium. Concomitant mTOR inhibitors (eg, sirolimus, temsirolimus, everolimus); consider dose reductions of both drugs. Monitor heart rate with concomitant clonidine.

See Also:

CALAN SR

Pharmacological Class:

Calcium channel blocker (CCB) (diphenylalkylamine).

Adverse Reactions:

Constipation, dizziness, nausea, hypotension, headache, edema, CHF, fatigue, dyspnea, bradycardia, AV block, rash, flushing, elevated hepatic enzymes, paralytic ileus.

How Supplied:

Calan 40mg—100; 80mg—100, 500, 1000; 120mg—100, 1000; SR 120mg, 180mg—100; SR 240mg—100, 500

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