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BYSTOLIC
Hypertension
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Drug Name:

BYSTOLIC Rx

Generic Name and Formulations:
Nebivolol (as HCl) 2.5mg, 5mg, 10mg, 20mg; tabs.

Company:
Allergan

Therapeutic Use:

Indications for BYSTOLIC:

Hypertension.

Adult:

≥18yrs: initially 5mg once daily. Individualize; may increase at 2-week intervals; max 40mg/day. Severe renal or moderate hepatic impairment: initially 2.5mg once daily.

Children:

<18yrs: not recommended.

Contraindications:

Severe hepatic impairment (Child-Pugh >B). Severe bradycardia. 2nd- or 3rd-degree AV block. Cardiogenic shock. Overt heart failure. Sick sinus syndrome (unless paced).

Warnings/Precautions:

CHF. Angina. Recent MI. Bronchospastic disease. Diabetes. Hyperthyroidism. Severe renal impairment. Moderate hepatic impairment. Avoid abrupt cessation (taper over 1–2 weeks). Surgery. Peripheral vascular disease. Pheochromocytoma. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Caution with phenylalkylamine and benzothiazepine calcium channel blockers (eg, verapamil, diltiazem), antiarrhythmics (eg, disopyramide), digoxin, reserpine, guanethidine; monitor. May be potentiated by CYP2D6 inhibitors (eg, quinidine, propafenone, paroxetine, fluoxetine); may need to reduce dose. If on both nebivolol and clonidine, discontinue nebivolol before tapering clonidine. May block epinephrine.

Pharmacological Class:

Cardioselective beta-blocker.

Adverse Reactions:

Headache, fatigue, dizziness, GI upset.

How Supplied:

Tabs—30, 100

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