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BONIVA INJECTION
Bone disorders
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Drug Name:

BONIVA INJECTION Rx

Generic Name and Formulations:
Ibandronate (as sodium) 3mg/3mL; soln for IV inj.

Company:
Genentech, Inc.

Therapeutic Use:

Indications for BONIVA INJECTION:

Prevention and treatment of postmenopausal osteoporosis.

Limitations Of use:

Optimal duration of use has not been determined. For patients at low-risk for fracture: consider drug discontinuation after 3–5yrs.

Adult:

Must be given by healthcare professional. Give as IV bolus inj over 15–30secs. 3mg every 3 months; if dose is missed, give as soon as possible, then every 3 months from the date of last inj.

Children:

Not established.

Contraindications:

Hypocalcemia. Tabs: Esophagus abnormalities which delay esophageal emptying (eg, stricture, achalasia). Inability to stand or sit upright for at least 60mins.

Warnings/Precautions:

Active upper GI disease; discontinue and reevaluate if signs/symptoms of esophageal reaction occur. Severe renal impairment (CrCl <30mL/min): not recommended. Correct preexisting hypocalcemia, other mineral or bone disturbances before starting. Risk of osteonecrosis of the jaw; consider discontinuing therapy during invasive dental procedures (eg, tooth extraction, implants, surgery). History of bisphosphonate exposure: evaluate for atypical fractures if thigh/groin pain develops; consider withholding therapy until risk/benefit assessment. Ensure adequate Vit. D and calcium intake. Reevaluate periodically. Inj: check renal function before each dose. Pregnancy. Nursing mothers.

Interactions:

Calcium, aluminum, magnesium, other multivalent cations reduce absorption (separate dosing by at least 60mins). Caution with aspirin, NSAIDs, other GI irritants. May interfere with bone-imaging agents. Inj: concomitant nephrotoxic agents; monitor for renal toxicity.

See Also:

BONIVA

Pharmacological Class:

Bisphosphonate.

Adverse Reactions:

Back pain, dyspepsia, pain in extremity, diarrhea, headache, myalgia; musculoskeletal pain (discontinue if severe), esophagitis, esophageal or gastric ulcer, jaw osteonecrosis, atypical femur fractures. Inj: inj site reactions, flu-like syndrome, anaphylaxis.

Generic Availability:

YES

How Supplied:

Blister pack—3; Kit—1 (prefilled syringe + supplies)

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