Bipolar

Does Methylphenidate Lead to Treatment-Emergent Mania?

Does Methylphenidate Lead to Treatment-Emergent Mania?

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Patients with comorbid bipolar disorder and ADHD may benefit from methylphenidate treatment, if it can be done without incurring the risk of mania.

Searching for Novel Endophenotypic Markers for Bipolar Disorder

Searching for Novel Endophenotypic Markers for Bipolar Disorder

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Intra-subject variability in reaction time (ISVRT) is viewed as a promising behavioral endophenotype for bipolar disorder.

Interaction of Proline and COMT Genotype Influences Negative Symptoms in Schizophrenia & Bipolar Disorder

Interaction of Proline and COMT Genotype Influences Negative Symptoms in Schizophrenia & Bipolar Disorder

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The authors explored whether valproate (VPA) treatment effects vary by catechol-O-methyltransferase (COMT) genotype.

Treatment Rates Far from Meeting Increasing Global Burden of Bipolar Disorder

Treatment Rates Far from Meeting Increasing Global Burden of Bipolar Disorder

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Insights from the Global Burden of Disease Study 2013

6-minute Walk Test Offers Insight Into Global Functioning Among Patients With Bipolar Disorder

6-minute Walk Test Offers Insight Into Global Functioning Among Patients With Bipolar Disorder

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Until now, assessment of aerobic exercise capacity included expensive and time-consuming laboratory tests that do not necessarily accurately reflect patients' day-to-day physical functioning.

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

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Bipolar disorder and schizophrenia are characterized by significant genetic overlap, as well as significant clinical presentation overlap.

Cortical Molecular Markers Differentiate Psychotic, Bipolar Disorders

Cortical Molecular Markers Differentiate Psychotic, Bipolar Disorders

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The researchers quantified the transcript levels of GAD67, parvalbumin, somastatin, and Lhx6 in the prefrontal cortex.

Bipolar Disorder Linked With Gene Expression in Unexpected Brain Region

Bipolar Disorder Linked With Gene Expression in Unexpected Brain Region

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New findings underline the potential importance of signaling pathways in the striatum for understanding bipolar disorder pathophysiology.

Exposure to Stressful Triggers Increases Risk for Violent Criminality Irrespective of Psychiatric Condition

Exposure to Stressful Triggers Increases Risk for Violent Criminality Irrespective of Psychiatric Condition

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The largest 7-day absolute risk of criminal violence was observed after exposure to violence in patients diagnosed with schizophrenia, bipolar disorder, as well as in unaffected individuals.

Following an Episode of Mania, Adults With Bipolar Disorder at Equal Risk for Depression or Anxiety

Following an Episode of Mania, Adults With Bipolar Disorder at Equal Risk for Depression or Anxiety

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Bipolar disorder (BD) is typically characterized by recurrent episodes of mania and depression, but the connection between BD and anxiety needs to be considered.

What Neuroimaging Can Teach us About Depression

What Neuroimaging Can Teach us About Depression

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Neuroimaging studies have shown several neurophysiological substrates for depression: An overview by Theodore Henderson, MD, PhD.

CDC Report: Jobs With the Highest Suicide Rates

CDC Report: Jobs With the Highest Suicide Rates

Events that happen in childhood and adolescence can predispose individuals to suicidal behavior.

Do Mobile Applications Have a Place in Managing Bipolar Disorder?

Do Mobile Applications Have a Place in Managing Bipolar Disorder?

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Great potential exists for using objective smartphone data to discriminate between depressive and manic states in patients with bipolar disorder.

Increased Incidence of Comorbid Bipolar Disorder and Asthma

Increased Incidence of Comorbid Bipolar Disorder and Asthma

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Research identifies high comorbidity rates between these 2 distinct diseases with underlying inflammation dysfunction.

Brain Abnormalities May Be Biomarkers for Bipolar Disorder

Brain Abnormalities May Be Biomarkers for Bipolar Disorder

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Research in recent decades has found structural brain abnormalities in patients with bipolar disorder, but such observations had not been translated into objective and clinically useful biomarkers.

Theory of Mind Decoding Impairment Associated With Mania in Bipolar Disorder

Theory of Mind Decoding Impairment Associated With Mania in Bipolar Disorder

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Theory of Mind refers to the ability to assign mental states to oneself and others based on social cues such as tone of voice and facial expressions.

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