Bipolar Disorders

Assortative Mating Among Bipolar Patients in the United States Increases Risk for Illness in Offspring

Assortative Mating Among Bipolar Patients in the United States Increases Risk for Illness in Offspring

By

The presence of unipolar depression in the spouse of someone with bipolar depression was associated with unipolar depression in their offspring, who had a 41.5% risk for developing that disorder.

Panel Recommends Earlier Body Weight Monitoring in Use of Mood Stabilizers

Panel Recommends Earlier Body Weight Monitoring in Use of Mood Stabilizers

By

Mood stabilizers are useful for long-term management of bipolar disorder, but weight change can create an emotional burden for some patients, as well as heighten the risk for metabolic dysregulation.

Text Message Reminders Improve Medication Adherence in Bipolar I Disorder

Text Message Reminders Improve Medication Adherence in Bipolar I Disorder

By

Researchers emphasize the cost-effectiveness of text message reminders in prompting individuals with bipolar I disorder to adhere to medication treatments.

Pilot Study Investigates Lithium vs Quetiapine for Bipolar Spectrum Disorder

Pilot Study Investigates Lithium vs Quetiapine for Bipolar Spectrum Disorder

By

This pilot study demonstrates the potential efficacy and safety of lithium as a treatment option for bipolar disorder.

Polygenic Risk Scores Could Aid in Identifying Bipolar Disorder, Schizophrenia

Polygenic Risk Scores Could Aid in Identifying Bipolar Disorder, Schizophrenia

By

While polygenic risk scores are not yet ready for clinical use, researchers found that patients with psychosis had significant increases in schizophrenia and bipolar polygenic risk scores.

Smartphone-Based Psychoeducational Programs May Be Effective for Bipolar Disorder Management

Smartphone-Based Psychoeducational Programs May Be Effective for Bipolar Disorder Management

By

This research supports the efficacy of smartphone-based educational programs in the management of bipolar disorder.

Lithium Monotherapy Effective in Treating Bipolar Disorder in Children

Lithium Monotherapy Effective in Treating Bipolar Disorder in Children

By

In terms of efficacy, 3 randomized controlled trials demonstrated that treatment with lithium monotherapy improved overall functioning and symptoms of mania or mixed mania in children and adolescents with bipolar illness.

Circadian Clock Genes Associated With Alcohol Dependence in Men

Circadian Clock Genes Associated With Alcohol Dependence in Men

By

Researchers confirmed the existence of a direct link between clock genes and 2 comorbid diseases, as well as the genetic predisposition for alcohol abuse.

Childhood Trauma Associated With Impulsivity in Bipolar Disorder

Childhood Trauma Associated With Impulsivity in Bipolar Disorder

By

Patients with bipolar disorder most often reported emotional abuse, emotional neglect, and physical neglect.

Lithium Efficacy, Safety Examined in Children, Adolescents With Bipolar Disorder

Lithium Efficacy, Safety Examined in Children, Adolescents With Bipolar Disorder

By

With regard to safety, treatment with lithium in this patient population was considered "generally safe, at least in the short term."

Reducing Off-Label Quetiapine Prescribing the Old-Fashioned Way: Snail Mail

Reducing Off-Label Quetiapine Prescribing the Old-Fashioned Way: Snail Mail

By

Despite the associated risk for death and cognitive decline, "off-label" prescribing of antipsychotics in patients with dementia has increased.

Unexpected Effect of Substance Use Disorders on Recovery From Bipolar Depression

Unexpected Effect of Substance Use Disorders on Recovery From Bipolar Depression

By

Contrary to the investigators' hypotheses, it was found that current co-occurring substance use disorders could significantly predict the likelihood of recovery from an episode of bipolar depression, as well as the time to recovery.

Tolerability of Novel Long-Acting Injectable Aripiprazole Tested for Bipolar Disorder

Tolerability of Novel Long-Acting Injectable Aripiprazole Tested for Bipolar Disorder

By

The study was designed to examine the adverse effect profile of a long-acting injectable version of the established oral treatment aripiprazole, in particular extrapyramidal symptoms such as akathisia and weight gain.

Coping Strategies for Amplified Emotionality May Improve Bipolar Disorder Symptoms

Coping Strategies for Amplified Emotionality May Improve Bipolar Disorder Symptoms

By

The findings confirmed amplified emotionality associated with bipolar disorder and demonstrated fluctuations in different components of coping flexibility and mood states across time.

Cortical Thickness Reduced in Schizophrenia Compared With Bipolar Disorder

Cortical Thickness Reduced in Schizophrenia Compared With Bipolar Disorder

By

There was no similarity in cortical thinning between patients with schizophrenia and psychotic bipolar I disorder.

Cortical Folding Patterns Related to Bipolar Disorder Subtypes

Cortical Folding Patterns Related to Bipolar Disorder Subtypes

By

This research supports a hypothesis that bipolar disorder is a "heterogeneous clinical entity that may be partially disentangled using brain imaging."

Poor Concentration, Restlessness May Predict Course of Bipolar Disorder

Poor Concentration, Restlessness May Predict Course of Bipolar Disorder

By

Because patients with bipolar disorder face a risk for suicide that is 20 to 30 times that of the general population, uncovering predictors of illness course is critical.

FDA Approval of Medication With a Digital Monitoring System: Major Breakthrough or "Brave New World"?

FDA Approval of Medication With a Digital Monitoring System: Major Breakthrough or "Brave New World"?

By

Abilify MyCite adds a digital sensor to the medication aripiprazole. The sensor, an ingestible event marker, is activated by contact with stomach acids and transmits a signal to a skin patch the patient wears, which then transmits to an app.

Electroconvulsive Therapy Improves Global Cognition in Bipolar Disorder

Electroconvulsive Therapy Improves Global Cognition in Bipolar Disorder

By

These data confirm the efficacy of ECT in treating mania and indicate that ultrabrief right unilateral ECT specifically may be useful for improving the symptoms and global cognition of patients with bipolar disorder.

Sodium Valproate May Lower Amygdala Volume in Pediatric Bipolar Disorder

Sodium Valproate May Lower Amygdala Volume in Pediatric Bipolar Disorder

By

Studies conducted in animals and adults have indicated that sodium valproate may have neuroprotective and neurotrophic effects, but the effects of sodium valproate on brain structure in pediatric bipolar disorder are not known.

Distinct Characteristics in Children at Risk for Schizophrenia vs Bipolar Disorder

Distinct Characteristics in Children at Risk for Schizophrenia vs Bipolar Disorder

By

The findings of this study contribute to the understanding of the neurodevelopmental cognitive vulnerability in middle childhood for the children of people with either schizophrenia or bipolar disorder.

Executive Function Impairment in Unipolar vs Bipolar Depression

Executive Function Impairment in Unipolar vs Bipolar Depression

By

These results suggest that executive function impairments may be similar in patients with unipolar and bipolar depression.

Managing Comorbid Migraine and Mood Disorders: A Synergistic Approach

Managing Comorbid Migraine and Mood Disorders: A Synergistic Approach

By

People with migraines and comorbid mood disorders often need treatments that address both conditions, as well as management of sleep, stress, and lifestyle issues.

Once-Monthly Aripiprazole Effective as Maintenance Treatment for Bipolar I Disorder

Once-Monthly Aripiprazole Effective as Maintenance Treatment for Bipolar I Disorder

By

These data demonstrate the efficacy and safety of AOM 400 in long-term maintenance treatment of bipolar I disorder and support its broader use in the medical field.

Childhood Abuse Linked to Compromised White Matter Integrity in Bipolar Disorder

Childhood Abuse Linked to Compromised White Matter Integrity in Bipolar Disorder

By

These findings are in line with previous research, which suggested that abuse and neglect in childhood have different effects on the brain.

Medication Adherence Predictors in Patients With Severe Psychiatric Disorders

Medication Adherence Predictors in Patients With Severe Psychiatric Disorders

By

As antipsychotic medications are vital to the effective management of severe psychiatric disorders, investigators sought to examine reasons for medication nonadherence in patients with schizophrenia, bipolar disorders, and other psychotic disorders.

Abnormal Frontal Gyrus, Limbic Activity Observed During Attentional Activity in Pediatric Bipolar Disorder

Abnormal Frontal Gyrus, Limbic Activity Observed During Attentional Activity in Pediatric Bipolar Disorder

By

These results may be helpful in elucidating the specific brain mechanisms of bipolar disorder during cognitive development.

Personality Disorders Related to Adverse Outcomes in Bipolar Disorder

Personality Disorders Related to Adverse Outcomes in Bipolar Disorder

By

These data may lead to a more nuanced understanding of bipolar disorder and to a better definition of the effectiveness of interventions directed at treating both personality disorders and bipolar disorder.

Relationship Between Impulsivity, Sleep Changes in Adolescents With Bipolar Disorder

Relationship Between Impulsivity, Sleep Changes in Adolescents With Bipolar Disorder

By

Sleep routines may be an important therapeutic target for adolescents with bipolar disorder.

Examining Treatment Modalities for Noninvasive Brain Stimulation for Adult Depression

Examining Treatment Modalities for Noninvasive Brain Stimulation for Adult Depression

By

These data could be useful to clinicians and patients alike in selecting the proper treatment method.

Sign Up for Free e-newsletters