Assortative Mating Among Bipolar Patients in the United States Increases Risk for Illness in OffspringSeptember 25, 2018
The presence of unipolar depression in the spouse of someone with bipolar depression was associated with unipolar depression in their offspring, who had a 41.5% risk for developing that disorder.
Mood stabilizers are useful for long-term management of bipolar disorder, but weight change can create an emotional burden for some patients, as well as heighten the risk for metabolic dysregulation.
Researchers emphasize the cost-effectiveness of text message reminders in prompting individuals with bipolar I disorder to adhere to medication treatments.
This pilot study demonstrates the potential efficacy and safety of lithium as a treatment option for bipolar disorder.
While polygenic risk scores are not yet ready for clinical use, researchers found that patients with psychosis had significant increases in schizophrenia and bipolar polygenic risk scores.
This research supports the efficacy of smartphone-based educational programs in the management of bipolar disorder.
In terms of efficacy, 3 randomized controlled trials demonstrated that treatment with lithium monotherapy improved overall functioning and symptoms of mania or mixed mania in children and adolescents with bipolar illness.
Researchers confirmed the existence of a direct link between clock genes and 2 comorbid diseases, as well as the genetic predisposition for alcohol abuse.
Patients with bipolar disorder most often reported emotional abuse, emotional neglect, and physical neglect.
With regard to safety, treatment with lithium in this patient population was considered "generally safe, at least in the short term."
Despite the associated risk for death and cognitive decline, "off-label" prescribing of antipsychotics in patients with dementia has increased.
Contrary to the investigators' hypotheses, it was found that current co-occurring substance use disorders could significantly predict the likelihood of recovery from an episode of bipolar depression, as well as the time to recovery.
The study was designed to examine the adverse effect profile of a long-acting injectable version of the established oral treatment aripiprazole, in particular extrapyramidal symptoms such as akathisia and weight gain.
The findings confirmed amplified emotionality associated with bipolar disorder and demonstrated fluctuations in different components of coping flexibility and mood states across time.
There was no similarity in cortical thinning between patients with schizophrenia and psychotic bipolar I disorder.
This research supports a hypothesis that bipolar disorder is a "heterogeneous clinical entity that may be partially disentangled using brain imaging."
Because patients with bipolar disorder face a risk for suicide that is 20 to 30 times that of the general population, uncovering predictors of illness course is critical.
FDA Approval of Medication With a Digital Monitoring System: Major Breakthrough or "Brave New World"?July 23, 2018
Abilify MyCite adds a digital sensor to the medication aripiprazole. The sensor, an ingestible event marker, is activated by contact with stomach acids and transmits a signal to a skin patch the patient wears, which then transmits to an app.
These data confirm the efficacy of ECT in treating mania and indicate that ultrabrief right unilateral ECT specifically may be useful for improving the symptoms and global cognition of patients with bipolar disorder.
Studies conducted in animals and adults have indicated that sodium valproate may have neuroprotective and neurotrophic effects, but the effects of sodium valproate on brain structure in pediatric bipolar disorder are not known.
The findings of this study contribute to the understanding of the neurodevelopmental cognitive vulnerability in middle childhood for the children of people with either schizophrenia or bipolar disorder.
These results suggest that executive function impairments may be similar in patients with unipolar and bipolar depression.
People with migraines and comorbid mood disorders often need treatments that address both conditions, as well as management of sleep, stress, and lifestyle issues.
These data demonstrate the efficacy and safety of AOM 400 in long-term maintenance treatment of bipolar I disorder and support its broader use in the medical field.
These findings are in line with previous research, which suggested that abuse and neglect in childhood have different effects on the brain.
As antipsychotic medications are vital to the effective management of severe psychiatric disorders, investigators sought to examine reasons for medication nonadherence in patients with schizophrenia, bipolar disorders, and other psychotic disorders.
Abnormal Frontal Gyrus, Limbic Activity Observed During Attentional Activity in Pediatric Bipolar DisorderJune 14, 2018
These results may be helpful in elucidating the specific brain mechanisms of bipolar disorder during cognitive development.
These data may lead to a more nuanced understanding of bipolar disorder and to a better definition of the effectiveness of interventions directed at treating both personality disorders and bipolar disorder.
Sleep routines may be an important therapeutic target for adolescents with bipolar disorder.
These data could be useful to clinicians and patients alike in selecting the proper treatment method.
Sign Up for Free e-newsletters
Psychiatry Advisor Articles
- Attention-Deficit/Hyperactivity Disorder Increasing Among US Children and Adolescents
- Combination Cognitive Behavioral Therapy With Fluoxetine Effective for Adolescent Depression
- Improving Medication Adherence in ADHD Lowers Risk for Oppositional Defiant Disorder, Conduct Disorder in Adulthood
- Antidepressant Effects of Ketamine Appear to Require Opioid System Activation
- Prazosin May Be Effective as Treatment for Alcohol Use Disorder
- Aggression in Bipolar I Disorder and Psychosis Associated With Suicide Ideation, Alcohol Abuse
- Moving Associated With Increased Risk for Psychosis in Children, Adolescents
- Omega-3 Polyunsaturated Fatty Acids Associated With Reduction in Anxiety Symptoms
- Neuroimaging Markers of Bipolar Disorder Risk for At-Risk Youth
- Suicide Attempt Risk Among LGB Populations Higher Than Previously Estimated