Bipolar Disorder

Bipolar Disorder: QoL Affected by Depression, Irritiability

Bipolar Disorder: QoL Affected by Depression, Irritiability

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Patients with bipolar disorder saw their quality of life affected by depression, irritability, and other psychiatric conditions.

Bipolar Disorder Mobile Apps May Not Address Consumer Needs

Bipolar Disorder Mobile Apps May Not Address Consumer Needs

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Bipolar disorder mental health mobile apps containing "wishlists" might not adequately meet consumer needs.

Bipolar Disorder, Schizophrenia, and Cardiometabolic Comorbidities Lead to Greater Mortality

Bipolar Disorder, Schizophrenia, and Cardiometabolic Comorbidities Lead to Greater Mortality

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Schizophrenia, mood disorders, and diabetes were among the top 20 conditions with the highest all-cause 30-day readmission rates.

Alcohol Abuse in Patients With Bipolar Disorder May Be Treatable

Alcohol Abuse in Patients With Bipolar Disorder May Be Treatable

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Two OTC supplements may improve brain function and mood control in patients diagnosed with bipolar disorder.

Lithium Use in Bipolar Disorder Not Linked to Increased Cancer Risk

Lithium Use in Bipolar Disorder Not Linked to Increased Cancer Risk

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Lithium treatment was not associated with the overall cancer risk in Swedish patients with bipolar disorder in the age group 50-84 years.

Lower Bipolar Disorder Rehospitalization Rate With Atypical Antipsychotics

Lower Bipolar Disorder Rehospitalization Rate With Atypical Antipsychotics

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Patients discharged with a mood stabilizer and an atypical antipsychotic had the lowest rehospitalization rate.

Bipolar Disorder and Association With Immune Dysfunction

Bipolar Disorder and Association With Immune Dysfunction

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Immune dysfunction may mediate the link between bipolar disorder and medical comorbidities.

Brain Scan Reveals Link Between Bipolar Disorder and Suicide Risk

In a new study, teens and young adults with bipolar disorder who had attempted suicide had slightly less volume and activity in areas of the brain that regulate emotion and impulses.

Untreated Psychotic Illness: Stemming the Tide

Untreated Psychotic Illness: Stemming the Tide

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Delays in treatment for psychosis can be associated with poorer outcomes.

Best Practices for Treatment of Bipolar Disorder

Best Practices for Treatment of Bipolar Disorder

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While lithium has been the mainstay of treatment for decades, several other classes of medication have recently been used with varying degrees of success.

Combination Treatment More Effective After Bipolar Episode

Combination Treatment More Effective After Bipolar Episode

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Atypical antipsychotic adjunctive therapy to mood stabilizers may be more effective than mood stabilizer monotherapy.

Bipolar Disorder Monotherapy Treatment Approved

Bipolar Disorder Monotherapy Treatment Approved

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For the acute treatment of manic or mixed episodes in bipolar I disorder, the recommended starting and treatment dose is now 5-10mg twice daily.

Slightly Higher HIV Screening in Patients With Severe Mental Illness

Slightly Higher HIV Screening in Patients With Severe Mental Illness

This study included Medicaid patients taking medications to treat bipolar disorder, schizophrenia, or major depression with psychosis.

Lithium Side Effects for Bipolar Disorder Lead to Lower Prescription Rates

Lithium Side Effects for Bipolar Disorder Lead to Lower Prescription Rates

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Lithium prescription rates for patients with bipolar disorder have declined during the last decade.

Psychoeducation No More Effective Than Peer Support at Reducing Time to Next Bipolar Episode

Psychoeducation No More Effective Than Peer Support at Reducing Time to Next Bipolar Episode

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Group psychoeducation is a low-cost psychological intervention with specific clinical benefits in early bipolar disorder, if the focus of care is preventing future mania relapse and improving self-management, interpersonal function, and support.

Smartphone Questionnaire Effective for Long-Term Monitoring of Mood Instability

Smartphone Questionnaire Effective for Long-Term Monitoring of Mood Instability

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The Mood Zoom questionnaire asks users to rate anxiety, elation, sadness, anger, irritability, and energy on a 7-point Likert scale

Cognitive Reserve May Predict Neurocognitive Performance in Bipolar Disorder

Cognitive Reserve May Predict Neurocognitive Performance in Bipolar Disorder

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Programs conducted in early stages of bipolar disorder to improve cognition and functioning may boost cognitive reserve and thus, help prevent cognitive decline.

Altered Connectivity in 2 Brain Networks Differentiate Bipolar Mood States

Altered Connectivity in 2 Brain Networks Differentiate Bipolar Mood States

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One line of future research in this area will be examining whether dorsal attention network connectivity predicts behavioral performance and emotional reactivity.

Low Levels of Vitamin D in Patients With Bipolar Disorder

Low Levels of Vitamin D in Patients With Bipolar Disorder

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Approximately 2.5% of people worldwide are estimated to have bipolar spectrum disorders, which are a significant cause of neuropsychiatric disability.

Haloperidol in the Emergency Department Setting

Haloperidol in the Emergency Department Setting

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Dr. Scott Zeller suggests it is time to move away from emergency intramuscular haloperidol.

Does Methylphenidate Lead to Treatment-Emergent Mania?

Does Methylphenidate Lead to Treatment-Emergent Mania?

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Patients with comorbid bipolar disorder and ADHD may benefit from methylphenidate treatment, if it can be done without incurring the risk of mania.

Searching for Novel Endophenotypic Markers for Bipolar Disorder

Searching for Novel Endophenotypic Markers for Bipolar Disorder

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Intra-subject variability in reaction time (ISVRT) is viewed as a promising behavioral endophenotype for bipolar disorder.

Gene Sets Altered Across Brain Regions in Schizophrenia, Bipolar Disorder & MDD

Gene Sets Altered Across Brain Regions in Schizophrenia, Bipolar Disorder & MDD

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Until now, the majority of postmortem research that has examined functionally related gene sets has been limited to a single disorder or region of the brain.

Bipolar and Schizophrenia Disorders Accurately Predicted With WERCAP Sections

Bipolar and Schizophrenia Disorders Accurately Predicted With WERCAP Sections

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By using the Washington Early Recognition Center Affectivity and Psychosis (WERCAP) questionnaire, investigators accurately predicted bipolar disorder or schizophrenia in more than 85% of patients.

Cohort Effect May Be Responsible For Increased Severity, Earlier Diagnoses in Bipolar Disorder

Cohort Effect May Be Responsible For Increased Severity, Earlier Diagnoses in Bipolar Disorder

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Findings suggest that in families with 2 generations of direct progenitors with bipolar disorder, an increase in bipolar disorder severity in future generations is likely.

Bipolar Disorder Treatment Initiated Early Found More Effective

Bipolar Disorder Treatment Initiated Early Found More Effective

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Treatment initiated in the early stages of bipolar disorder was found more effective than treatment in later stages.

Interaction of Proline and COMT Genotype Influences Negative Symptoms in Schizophrenia & Bipolar Disorder

Interaction of Proline and COMT Genotype Influences Negative Symptoms in Schizophrenia & Bipolar Disorder

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The authors explored whether valproate (VPA) treatment effects vary by catechol-O-methyltransferase (COMT) genotype.

Brain-derived Neurotrophic Factor and its Precursor proBDNF as Diagnostic Biomarkers for Mood Disorders

Brain-derived Neurotrophic Factor and its Precursor proBDNF as Diagnostic Biomarkers for Mood Disorders

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mBDNF/proBDNF ratio could potentially serve as a novel biomarker for mood disorders.

Treatment Rates Far from Meeting Increasing Global Burden of Bipolar Disorder

Treatment Rates Far from Meeting Increasing Global Burden of Bipolar Disorder

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Insights from the Global Burden of Disease Study 2013

Immune Biomarkers Identified in Patients With Bipolar Disorder During Manic Episodes

Immune Biomarkers Identified in Patients With Bipolar Disorder During Manic Episodes

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The immune system dysregulation may lead to or exacerbate neuropsychiatric conditions such as bipolar disorder.

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