Bipolar Disorder

A Slow Road Toward Personalized Treatment of Bipolar Disorder

A Slow Road Toward Personalized Treatment of Bipolar Disorder

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Successful management of both the manic and depressive states in bipolar disorder has been difficult to achieve, despite a broad range of pharmacologic treatments available.

Probing the Link Between Mood Disorders and Lithium in Water Supplies

Probing the Link Between Mood Disorders and Lithium in Water Supplies

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Michael Thase, MD, comments on the potential for lithium in drinking water as a psychiatric prophylactic agent.

Psychosis Associated With Increased Complications Following Total Joint Arthroplasty

Psychosis Associated With Increased Complications Following Total Joint Arthroplasty

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Investigators seek the association between psychosis and complication risk after total joint arthroplasty.

Exploring Safe and Effective Treatments for Bipolar Depression: Transcranial Direct Current Stimulation

Exploring Safe and Effective Treatments for Bipolar Depression: Transcranial Direct Current Stimulation

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Transcranial direct current stimulation may be an effective add-on treatment for bipolar depression.

Managing Comorbid Bipolar Disorder and Alcohol Use Disorder: Clinical Challenges and Conundrums

Managing Comorbid Bipolar Disorder and Alcohol Use Disorder: Clinical Challenges and Conundrums

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The frequent comorbidity of bipolar disorder and alcohol use disorder presents a significant challenge for clinicians managing patients with these conditions.

Lurasidone Monotherapy Safe, Efficacious in Children, Adolescents With Bipolar Depression

Lurasidone Monotherapy Safe, Efficacious in Children, Adolescents With Bipolar Depression

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Safety and efficacy of lurasidone monotherapy were assessed in children and adolescents with bipolar I depression.

Pregnancy and Bipolar Disorder: Expert Interview With Leena Mittal, MD

Pregnancy and Bipolar Disorder: Expert Interview With Leena Mittal, MD

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The Oregon Foundation for Reproductive Health recommends that all medical providers ask all female patients of reproductive age if they plan to become pregnant in the next year.

Neurocognitive Function Improved After 1 Year in Non-Relapsing Bipolar I Disorder

Neurocognitive Function Improved After 1 Year in Non-Relapsing Bipolar I Disorder

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Patients with bipolar I disorder without relapse after 1 year of first treatment had improved neurocognitive functioning.

Monetary Incentives Improve Cessation in Mentally Ill Smokers

Monetary Incentives Improve Cessation in Mentally Ill Smokers

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Abstinence-contingent incentives improved smoking cessation outcomes among economically disadvantaged smokers with mental illness.

Bipolar Disorder, Borderline Personality Disorder May Represent the Same Disorder

Bipolar Disorder, Borderline Personality Disorder May Represent the Same Disorder

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Bipolar disorder and borderline personality disorder reflect alternate expressions of the same underlying disorder.

Benefits of Psychoeducation in Bipolar Disorder Mediated by Perceived Improvement

Benefits of Psychoeducation in Bipolar Disorder Mediated by Perceived Improvement

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The benefits of psychoeducation for patients with bipolar disorder were mediated by perceived change in illness.

Residual Anxiety Predicts Depression Relapse in Bipolar II Depression

Residual Anxiety Predicts Depression Relapse in Bipolar II Depression

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Venlafaxine was superior to lithium in reducing symptoms of both bipolar II depression and anxiety.

Association of Schizophrenia-Related Polygenic-Risk Score Across Bipolar Disorder Subtypes

Association of Schizophrenia-Related Polygenic-Risk Score Across Bipolar Disorder Subtypes

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A schizophrenia-related polygenic-risk score association gradient was identified across bipolar disorder phenotypes.

Psychotic Symptom Severity in BPAD Inversely Linked to Lithium Response

Psychotic Symptom Severity in BPAD Inversely Linked to Lithium Response

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The severity of psychotic symptoms in patients with bipolar affective disorder correlated inversely with the response to lithium therapy.

Predictors of Aggression in Patients With Bipolar Disorder, Schizophrenia

Predictors of Aggression in Patients With Bipolar Disorder, Schizophrenia

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Patients with schizophrenia-spectrum disorders had higher odds of being aggressive than people with bipolar disorder with a recent manic episode.

FDA Approves Schizophrenia Medication With Digital Ingestion Sensor

FDA Approves Schizophrenia Medication With Digital Ingestion Sensor

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The ability to track ingestion of medications prescribed for mental illness may be useful for some patients.

No Association Between Comorbid Anxiety Disorders, Suicide Attempts

No Association Between Comorbid Anxiety Disorders, Suicide Attempts

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Comorbid anxiety disorders among patients with depression or bipolar disorder were not associated with suicide attempts.

Lurasidone Reduces Depression in Children With Bipolar Disorder

Lurasidone Reduces Depression in Children With Bipolar Disorder

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Researchers evaluated the safety and efficacy of lurasidone in children and adolescents with bipolar depression.

Computerized Cognitive Remediation Improves Cognition in Bipolar Disorder

Computerized Cognitive Remediation Improves Cognition in Bipolar Disorder

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Inclusion of supportive elements such as rehabilitation may help drive translation of cognitive improvements to broad functional measures.

Elevated Dopamine Synthesis Capacity Observed in Both Bipolar and Schizophrenia

Elevated Dopamine Synthesis Capacity Observed in Both Bipolar and Schizophrenia

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Dopamine dysfunction underlies the pathoetiology of psychosis in both bipolar disorder and schizophrenia.

Asenapine Prevents Recurrence of Mood Events in Bipolar Disorder

Asenapine Prevents Recurrence of Mood Events in Bipolar Disorder

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Asenapine decreases the time to recurrence of manic and depressive episodes among patients with bipolar I disorder.

Bipolar Depression Benefits From Midday Bright Light Therapy

Bipolar Depression Benefits From Midday Bright Light Therapy

Bright light therapy might be effective for the treatment of bipolar depression.

ADHD, Comorbid Bipolar Disorder Share Similar Neurocognitive Profiles

ADHD, Comorbid Bipolar Disorder Share Similar Neurocognitive Profiles

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People with both bipolar disorder and ADHD have similar neurocognitive profiles compared with people with only bipolar disorder.

Olanzapine Effective in Treating Severe Mania Symptoms

Olanzapine Effective in Treating Severe Mania Symptoms

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Olanzapine was shown to be effective among patients with acute mania associated with bipolar I disorder.

Lithium Reduces Risk of Suicide in Patients With Mood Disorders

Lithium Reduces Risk of Suicide in Patients With Mood Disorders

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Lithium is the only medication to demonstrate an antisuicidal effect over and above its action on mood episodes in bipolar disorder.

Bipolar Disorder Therapy Response Possibly Impeded by Proinflammatory State

Bipolar Disorder Therapy Response Possibly Impeded by Proinflammatory State

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An M1-like proinflammatory state is associated with a poor response to antidepressant treatment in bipolar depression with evidence suggesting increased production of cytokines in patients with mood disorders.

Juvenile Bipolar Disorder: Intranasal Ketamine Effective, Well-Tolerated

Juvenile Bipolar Disorder: Intranasal Ketamine Effective, Well-Tolerated

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Ketamine improves social function and academic performance in juvenile patients with bipolar disorder with a fear of harm phenotype.

Antipsychotic Reduction in Bipolar Disorder, Depression: Higher Healthcare Burden

Antipsychotic Reduction in Bipolar Disorder, Depression: Higher Healthcare Burden

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For patients with bipolar disorder and major depressive disorder, reduction in dose of antipsychotic medication could lead to an increased rate of hospitalization.

Effect of Mixed State on Suicidal Behavior in Patients With Bipolar Disorder

Effect of Mixed State on Suicidal Behavior in Patients With Bipolar Disorder

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Mixed state does not increase the risk for suicidal behavior beyond the risk associated with the depressive component.

Psychosis Not Associated With Bipolar Disorder Severity

Psychosis Not Associated With Bipolar Disorder Severity

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Psychosis in patients with bipolar disorder was not associated with worse clinical or functional outcomes.

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