Bipolar Disorder

Smartphone Questionnaire Effective for Long-Term Monitoring of Mood Instability

Smartphone Questionnaire Effective for Long-Term Monitoring of Mood Instability

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The Mood Zoom questionnaire asks users to rate anxiety, elation, sadness, anger, irritability, and energy on a 7-point Likert scale

Cognitive Reserve May Predict Neurocognitive Performance in Bipolar Disorder

Cognitive Reserve May Predict Neurocognitive Performance in Bipolar Disorder

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Programs conducted in early stages of bipolar disorder to improve cognition and functioning may boost cognitive reserve and thus, help prevent cognitive decline.

Altered Connectivity in 2 Brain Networks Differentiate Bipolar Mood States

Altered Connectivity in 2 Brain Networks Differentiate Bipolar Mood States

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One line of future research in this area will be examining whether dorsal attention network connectivity predicts behavioral performance and emotional reactivity.

Low Levels of Vitamin D in Patients With Bipolar Disorder

Low Levels of Vitamin D in Patients With Bipolar Disorder

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Approximately 2.5% of people worldwide are estimated to have bipolar spectrum disorders, which are a significant cause of neuropsychiatric disability.

Haloperidol in the Emergency Department Setting

Haloperidol in the Emergency Department Setting

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Dr. Scott Zeller suggests it is time to move away from emergency intramuscular haloperidol.

Does Methylphenidate Lead to Treatment-Emergent Mania?

Does Methylphenidate Lead to Treatment-Emergent Mania?

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Patients with comorbid bipolar disorder and ADHD may benefit from methylphenidate treatment, if it can be done without incurring the risk of mania.

Searching for Novel Endophenotypic Markers for Bipolar Disorder

Searching for Novel Endophenotypic Markers for Bipolar Disorder

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Intra-subject variability in reaction time (ISVRT) is viewed as a promising behavioral endophenotype for bipolar disorder.

Gene Sets Altered Across Brain Regions in Schizophrenia, Bipolar Disorder & MDD

Gene Sets Altered Across Brain Regions in Schizophrenia, Bipolar Disorder & MDD

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Until now, the majority of postmortem research that has examined functionally related gene sets has been limited to a single disorder or region of the brain.

Bipolar and Schizophrenia Disorders Accurately Predicted With WERCAP Sections

Bipolar and Schizophrenia Disorders Accurately Predicted With WERCAP Sections

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By using the Washington Early Recognition Center Affectivity and Psychosis (WERCAP) questionnaire, investigators accurately predicted bipolar disorder or schizophrenia in more than 85% of patients.

Cohort Effect May Be Responsible For Increased Severity, Earlier Diagnoses in Bipolar Disorder

Cohort Effect May Be Responsible For Increased Severity, Earlier Diagnoses in Bipolar Disorder

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Findings suggest that in families with 2 generations of direct progenitors with bipolar disorder, an increase in bipolar disorder severity in future generations is likely.

Bipolar Disorder Treatment Initiated Early Found More Effective

Bipolar Disorder Treatment Initiated Early Found More Effective

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Treatment initiated in the early stages of bipolar disorder was found more effective than treatment in later stages.

Interaction of Proline and COMT Genotype Influences Negative Symptoms in Schizophrenia & Bipolar Disorder

Interaction of Proline and COMT Genotype Influences Negative Symptoms in Schizophrenia & Bipolar Disorder

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The authors explored whether valproate (VPA) treatment effects vary by catechol-O-methyltransferase (COMT) genotype.

Brain-derived Neurotrophic Factor and its Precursor proBDNF as Diagnostic Biomarkers for Mood Disorders

Brain-derived Neurotrophic Factor and its Precursor proBDNF as Diagnostic Biomarkers for Mood Disorders

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mBDNF/proBDNF ratio could potentially serve as a novel biomarker for mood disorders.

Treatment Rates Far from Meeting Increasing Global Burden of Bipolar Disorder

Treatment Rates Far from Meeting Increasing Global Burden of Bipolar Disorder

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Insights from the Global Burden of Disease Study 2013

Immune Biomarkers Identified in Patients With Bipolar Disorder During Manic Episodes

Immune Biomarkers Identified in Patients With Bipolar Disorder During Manic Episodes

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The immune system dysregulation may lead to or exacerbate neuropsychiatric conditions such as bipolar disorder.

6-minute Walk Test Offers Insight Into Global Functioning Among Patients With Bipolar Disorder

6-minute Walk Test Offers Insight Into Global Functioning Among Patients With Bipolar Disorder

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Until now, assessment of aerobic exercise capacity included expensive and time-consuming laboratory tests that do not necessarily accurately reflect patients' day-to-day physical functioning.

Irritability in Recovered Bipolar Disorder Patients Linked to Greater Morbidity, Depression Recurrence

Irritability in Recovered Bipolar Disorder Patients Linked to Greater Morbidity, Depression Recurrence

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Delayed depressive recovery occurred more in depressed patients with current irritability.

Cognition and White Matter Alterations in Schizophrenia, Bipolar Disorder

Cognition and White Matter Alterations in Schizophrenia, Bipolar Disorder

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Direct comparison of white matter tracts between individuals with schizophrenia or bipolar disorder has not been performed to date.

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

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Bipolar disorder and schizophrenia are characterized by significant genetic overlap, as well as significant clinical presentation overlap.

Cortical Molecular Markers Differentiate Psychotic, Bipolar Disorders

Cortical Molecular Markers Differentiate Psychotic, Bipolar Disorders

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The researchers quantified the transcript levels of GAD67, parvalbumin, somastatin, and Lhx6 in the prefrontal cortex.

Psychotropic Drug Indications

Drug comparisons for mood disorders such as bipolar disorder, major depressive disorder, treatment resistant depression, premenstrual dysphoric disorder, and others.

Average of 6 Years Between Onset and Diagnosis of Bipolar Disorder

Average of 6 Years Between Onset and Diagnosis of Bipolar Disorder

Researchers found that many patients have disruptive symptoms for years before they receive proper treatment.

Study Links Acute Mania With Antibiotic Usage

Study Links Acute Mania With Antibiotic Usage

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Investigators examined antibiotic use in patients with bipolar disorder, schizophrenia, and major depressive disorder.

Smoking Reduction Linked to Reduced Suicidality in Patients With Psychotic Conditions

Smoking Reduction Linked to Reduced Suicidality in Patients With Psychotic Conditions

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At 12 months, researchers found a significant association between smoking reduction and suicidality.

Aberrant Reward Processing Likely Precedes Psychotic Disorders

Aberrant Reward Processing Likely Precedes Psychotic Disorders

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Genetic risk for psychosis influences reward processing in healthy adolescents.

Bipolar Disorder Linked With Gene Expression in Unexpected Brain Region

Bipolar Disorder Linked With Gene Expression in Unexpected Brain Region

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New findings underline the potential importance of signaling pathways in the striatum for understanding bipolar disorder pathophysiology.

Exposure to Stressful Triggers Increases Risk for Violent Criminality Irrespective of Psychiatric Condition

Exposure to Stressful Triggers Increases Risk for Violent Criminality Irrespective of Psychiatric Condition

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The largest 7-day absolute risk of criminal violence was observed after exposure to violence in patients diagnosed with schizophrenia, bipolar disorder, as well as in unaffected individuals.

Following an Episode of Mania, Adults With Bipolar Disorder at Equal Risk for Depression or Anxiety

Following an Episode of Mania, Adults With Bipolar Disorder at Equal Risk for Depression or Anxiety

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Bipolar disorder (BD) is typically characterized by recurrent episodes of mania and depression, but the connection between BD and anxiety needs to be considered.

What Neuroimaging Can Teach us About Depression

What Neuroimaging Can Teach us About Depression

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Neuroimaging studies have shown several neurophysiological substrates for depression: An overview by Theodore Henderson, MD, PhD.

CDC Report: Jobs With the Highest Suicide Rates

CDC Report: Jobs With the Highest Suicide Rates

Events that happen in childhood and adolescence can predispose individuals to suicidal behavior.

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