Bipolar Disorder Archive

Lurasidone Reduces Depression in Children With Bipolar Disorder

Lurasidone Reduces Depression in Children With Bipolar Disorder

Researchers evaluated the safety and efficacy of lurasidone in children and adolescents with bipolar depression.

Elevated Dopamine Synthesis Capacity Observed in Both Bipolar and Schizophrenia

Elevated Dopamine Synthesis Capacity Observed in Both Bipolar and Schizophrenia

Dopamine dysfunction underlies the pathoetiology of psychosis in both bipolar disorder and schizophrenia.

Asenapine Prevents Recurrence of Mood Events in Bipolar Disorder

Asenapine Prevents Recurrence of Mood Events in Bipolar Disorder

Asenapine decreases the time to recurrence of manic and depressive episodes among patients with bipolar I disorder.

Bipolar Depression Benefits From Midday Bright Light Therapy

Bipolar Depression Benefits From Midday Bright Light Therapy

Bright light therapy might be effective for the treatment of bipolar depression.

ADHD, Comorbid Bipolar Disorder Share Similar Neurocognitive Profiles

ADHD, Comorbid Bipolar Disorder Share Similar Neurocognitive Profiles

People with both bipolar disorder and ADHD have similar neurocognitive profiles compared with people with only bipolar disorder.

Olanzapine Effective in Treating Severe Mania Symptoms

Olanzapine Effective in Treating Severe Mania Symptoms

Olanzapine was shown to be effective among patients with acute mania associated with bipolar I disorder.

Lithium Reduces Risk of Suicide in Patients With Mood Disorders

Lithium Reduces Risk of Suicide in Patients With Mood Disorders

Lithium is the only medication to demonstrate an antisuicidal effect over and above its action on mood episodes in bipolar disorder.

Bipolar Disorder Therapy Response Possibly Impeded by Proinflammatory State

Bipolar Disorder Therapy Response Possibly Impeded by Proinflammatory State

An M1-like proinflammatory state is associated with a poor response to antidepressant treatment in bipolar depression with evidence suggesting increased production of cytokines in patients with mood disorders.

Juvenile Bipolar Disorder: Intranasal Ketamine Effective, Well-Tolerated

Juvenile Bipolar Disorder: Intranasal Ketamine Effective, Well-Tolerated

Ketamine improves social function and academic performance in juvenile patients with bipolar disorder with a fear of harm phenotype.

Antipsychotic Reduction in Bipolar Disorder, Depression: Higher Healthcare Burden

Antipsychotic Reduction in Bipolar Disorder, Depression: Higher Healthcare Burden

For patients with bipolar disorder and major depressive disorder, reduction in dose of antipsychotic medication could lead to an increased rate of hospitalization.

Effect of Mixed State on Suicidal Behavior in Patients With Bipolar Disorder

Effect of Mixed State on Suicidal Behavior in Patients With Bipolar Disorder

Mixed state does not increase the risk for suicidal behavior beyond the risk associated with the depressive component.

Increased Psychotic Symptoms in Offspring of Patients With Schizophrenia

Increased Psychotic Symptoms in Offspring of Patients With Schizophrenia

Children and adolescent offspring of patients with schizophrenia demonstrate more attenuated psychotic symptoms.

Psychosis Not Associated With Bipolar Disorder Severity

Psychosis Not Associated With Bipolar Disorder Severity

Psychosis in patients with bipolar disorder was not associated with worse clinical or functional outcomes.

New Model Shows High Accuracy in Predicting Response to Lithium

New Model Shows High Accuracy in Predicting Response to Lithium

Lithium response may be predicted with better accuracy by a new model.

Long-term Response to Prophylactic Mood Stabilizers in Bipolar Disorder

Long-term Response to Prophylactic Mood Stabilizers in Bipolar Disorder

Mixed and psychotic features and comorbid anxiety disorder were associated with poor treatment response in bipolar disorder.

Risk of Mood Disorders Increased From Sugary Beverages, Foods

Risk of Mood Disorders Increased From Sugary Beverages, Foods

The risk for mood disorders increases with the more sugar consumed from beverages and food.

Youth With BD Do Not Experience Cognitive Decline Into Adulthood

Youth With BD Do Not Experience Cognitive Decline Into Adulthood

Bipolar disorder in youth does not exhibit a cognitive worsening over time.

FDA Approves Abilify Maintena for Bipolar I Disorder Monotherapy Treatment

FDA Approves Abilify Maintena for Bipolar I Disorder Monotherapy Treatment

New bipolar I disorder treatment Abilify Maintena is only required once a month.

Bipolar Disorder: Childhood Trauma Modulates Impact on Amygdala, Hippocampus

Bipolar Disorder: Childhood Trauma Modulates Impact on Amygdala, Hippocampus

Childhood trauma modulates the effects of bipolar disorder on the amygdala and hippocampus by causing an increase in the volumes of gray matter.

Bipolar Disorder in Pregnant Women Not Improved by Psychotropic Medications

Bipolar Disorder in Pregnant Women Not Improved by Psychotropic Medications

Pregnant women with bipolar disorder receiving psychotropic medication did not experience less functional impairment and symptom burden.

Bipolar Spectrum Disorder in Youth Predicted By New Risk Calculator

Bipolar Spectrum Disorder in Youth Predicted By New Risk Calculator

Bipolar disorder probability in the offspring of a parent with BP was assessed by a risk calculator.

Bipolar Disorder Adds to Sexual Distress Rate For Women

Bipolar Disorder Adds to Sexual Distress Rate For Women

Bipolar disorder was connected to both sexual distress and overall quality of life.

Analysis of Cognitive Impairment Tx Strategies in Bipolar Disorder

Analysis of Cognitive Impairment Tx Strategies in Bipolar Disorder

In bipolar disorder, neurocognitive impairment needs to be considered a therapeutic clinical target to improve psychosocial functioning.

Thyroid Disease Linked With Higher Rates of Manic Relapse In Bipolar Disorder

Thyroid Disease Linked With Higher Rates of Manic Relapse In Bipolar Disorder

Manic relapse in bipolar disorder is connected to thyroid disease.

Bipolar Disorder Relapse Episodes Delayed With Risperidone Treatment

Bipolar Disorder Relapse Episodes Delayed With Risperidone Treatment

Bipolar disorder mood relapse episodes were delayed with risperidone long-acting injection.

Lamotrigine: Alternate Bipolar Disorder Treatment to Lithium During Pregnancy

Lamotrigine: Alternate Bipolar Disorder Treatment to Lithium During Pregnancy

Bipolar disorder treatment with lamotrigine during pregnancy may also prevent postpartum depressive episodes.

Correct Bipolar Disorder Diagnosis Delayed By Depression Diagnosis At Younger Age

Correct Bipolar Disorder Diagnosis Delayed By Depression Diagnosis At Younger Age

Depressed patients with diagnoses that ultimately converted to bipolar disorder had been diagnosed with depression earlier.

Late Teen Emotional Stability Inversely Tied to Mental Illness

Late Teen Emotional Stability Inversely Tied to Mental Illness

Emotional stability assessed in late adolescence is inversely associated with serious mental illness.

Lithium Not Associated With Increased Cancer Risk in Bipolar Disorder

Lithium Not Associated With Increased Cancer Risk in Bipolar Disorder

Neither bipolar disorder nor lithium treatment was associated with increased cancer incidence.

Greater Cognitive Decline in Individuals at Risk for Bipolar Disorder With Obesity

Greater Cognitive Decline in Individuals at Risk for Bipolar Disorder With Obesity

The burden of illness associated with bipolar disorder warrants early preemption.

Negative Outcomes in Bipolar, Schizoaffective Disorder Linked to Irritability

Negative Outcomes in Bipolar, Schizoaffective Disorder Linked to Irritability

Irritability may have wide-ranging impacts on symptomatic, functional, and social elements of quality of life.

Bipolar Disorder Treatment Can Lead to Silent Thyroiditis

Bipolar Disorder Treatment Can Lead to Silent Thyroiditis

Careful monitoring of thyroid function is necessary for patients undergoing lithium therapy.

Bipolar Disorder: QoL Affected by Depression, Irritiability

Bipolar Disorder: QoL Affected by Depression, Irritiability

Patients with bipolar disorder saw their quality of life affected by depression, irritability, and other psychiatric conditions.

Bipolar Disorder Mobile Apps May Not Address Consumer Needs

Bipolar Disorder Mobile Apps May Not Address Consumer Needs

Bipolar disorder mental health mobile apps containing "wishlists" might not adequately meet consumer needs.

Bipolar Disorder, Schizophrenia, and Cardiometabolic Comorbidities Lead to Greater Mortality

Bipolar Disorder, Schizophrenia, and Cardiometabolic Comorbidities Lead to Greater Mortality

Schizophrenia, mood disorders, and diabetes were among the top 20 conditions with the highest all-cause 30-day readmission rates.

Alcohol Abuse in Patients With Bipolar Disorder May Be Treatable

Alcohol Abuse in Patients With Bipolar Disorder May Be Treatable

Two OTC supplements may improve brain function and mood control in patients diagnosed with bipolar disorder.

Lithium Use in Bipolar Disorder Not Linked to Increased Cancer Risk

Lithium Use in Bipolar Disorder Not Linked to Increased Cancer Risk

Lithium treatment was not associated with the overall cancer risk in Swedish patients with bipolar disorder in the age group 50-84 years.

Lower Bipolar Disorder Rehospitalization Rate With Atypical Antipsychotics

Lower Bipolar Disorder Rehospitalization Rate With Atypical Antipsychotics

Patients discharged with a mood stabilizer and an atypical antipsychotic had the lowest rehospitalization rate.

Bipolar Disorder and Association With Immune Dysfunction

Bipolar Disorder and Association With Immune Dysfunction

Immune dysfunction may mediate the link between bipolar disorder and medical comorbidities.

Brain Scan Reveals Link Between Bipolar Disorder and Suicide Risk

In a new study, teens and young adults with bipolar disorder who had attempted suicide had slightly less volume and activity in areas of the brain that regulate emotion and impulses.

Untreated Psychotic Illness: Stemming the Tide

Untreated Psychotic Illness: Stemming the Tide

Delays in treatment for psychosis can be associated with poorer outcomes.

Best Practices for Treatment of Bipolar Disorder

Best Practices for Treatment of Bipolar Disorder

While lithium has been the mainstay of treatment for decades, several other classes of medication have recently been used with varying degrees of success.

Combination Treatment More Effective After Bipolar Episode

Combination Treatment More Effective After Bipolar Episode

Atypical antipsychotic adjunctive therapy to mood stabilizers may be more effective than mood stabilizer monotherapy.

Bipolar Disorder Monotherapy Treatment Approved

Bipolar Disorder Monotherapy Treatment Approved

For the acute treatment of manic or mixed episodes in bipolar I disorder, the recommended starting and treatment dose is now 5-10mg twice daily.

Slightly Higher HIV Screening in Patients With Severe Mental Illness

Slightly Higher HIV Screening in Patients With Severe Mental Illness

This study included Medicaid patients taking medications to treat bipolar disorder, schizophrenia, or major depression with psychosis.

Lithium Side Effects for Bipolar Disorder Lead to Lower Prescription Rates

Lithium Side Effects for Bipolar Disorder Lead to Lower Prescription Rates

Lithium prescription rates for patients with bipolar disorder have declined during the last decade.

Psychoeducation No More Effective Than Peer Support at Reducing Time to Next Bipolar Episode

Psychoeducation No More Effective Than Peer Support at Reducing Time to Next Bipolar Episode

Group psychoeducation is a low-cost psychological intervention with specific clinical benefits in early bipolar disorder, if the focus of care is preventing future mania relapse and improving self-management, interpersonal function, and support.

Smartphone Questionnaire Effective for Long-Term Monitoring of Mood Instability

Smartphone Questionnaire Effective for Long-Term Monitoring of Mood Instability

The Mood Zoom questionnaire asks users to rate anxiety, elation, sadness, anger, irritability, and energy on a 7-point Likert scale

Cognitive Reserve May Predict Neurocognitive Performance in Bipolar Disorder

Cognitive Reserve May Predict Neurocognitive Performance in Bipolar Disorder

Programs conducted in early stages of bipolar disorder to improve cognition and functioning may boost cognitive reserve and thus, help prevent cognitive decline.

Altered Connectivity in 2 Brain Networks Differentiate Bipolar Mood States

Altered Connectivity in 2 Brain Networks Differentiate Bipolar Mood States

One line of future research in this area will be examining whether dorsal attention network connectivity predicts behavioral performance and emotional reactivity.

Low Levels of Vitamin D in Patients With Bipolar Disorder

Low Levels of Vitamin D in Patients With Bipolar Disorder

Approximately 2.5% of people worldwide are estimated to have bipolar spectrum disorders, which are a significant cause of neuropsychiatric disability.

Haloperidol in the Emergency Department Setting

Haloperidol in the Emergency Department Setting

Dr. Scott Zeller suggests it is time to move away from emergency intramuscular haloperidol.

Does Methylphenidate Lead to Treatment-Emergent Mania?

Does Methylphenidate Lead to Treatment-Emergent Mania?

Patients with comorbid bipolar disorder and ADHD may benefit from methylphenidate treatment, if it can be done without incurring the risk of mania.

Searching for Novel Endophenotypic Markers for Bipolar Disorder

Searching for Novel Endophenotypic Markers for Bipolar Disorder

Intra-subject variability in reaction time (ISVRT) is viewed as a promising behavioral endophenotype for bipolar disorder.

Gene Sets Altered Across Brain Regions in Schizophrenia, Bipolar Disorder & MDD

Gene Sets Altered Across Brain Regions in Schizophrenia, Bipolar Disorder & MDD

Until now, the majority of postmortem research that has examined functionally related gene sets has been limited to a single disorder or region of the brain.

Bipolar and Schizophrenia Disorders Accurately Predicted With WERCAP Sections

Bipolar and Schizophrenia Disorders Accurately Predicted With WERCAP Sections

By using the Washington Early Recognition Center Affectivity and Psychosis (WERCAP) questionnaire, investigators accurately predicted bipolar disorder or schizophrenia in more than 85% of patients.

Cohort Effect May Be Responsible For Increased Severity, Earlier Diagnoses in Bipolar Disorder

Cohort Effect May Be Responsible For Increased Severity, Earlier Diagnoses in Bipolar Disorder

Findings suggest that in families with 2 generations of direct progenitors with bipolar disorder, an increase in bipolar disorder severity in future generations is likely.

Bipolar Disorder Treatment Initiated Early Found More Effective

Bipolar Disorder Treatment Initiated Early Found More Effective

Treatment initiated in the early stages of bipolar disorder was found more effective than treatment in later stages.

Interaction of Proline and COMT Genotype Influences Negative Symptoms in Schizophrenia & Bipolar Disorder

Interaction of Proline and COMT Genotype Influences Negative Symptoms in Schizophrenia & Bipolar Disorder

The authors explored whether valproate (VPA) treatment effects vary by catechol-O-methyltransferase (COMT) genotype.

Immune Biomarkers Identified in Patients With Bipolar Disorder During Manic Episodes

Immune Biomarkers Identified in Patients With Bipolar Disorder During Manic Episodes

The immune system dysregulation may lead to or exacerbate neuropsychiatric conditions such as bipolar disorder.

6-minute Walk Test Offers Insight Into Global Functioning Among Patients With Bipolar Disorder

6-minute Walk Test Offers Insight Into Global Functioning Among Patients With Bipolar Disorder

Until now, assessment of aerobic exercise capacity included expensive and time-consuming laboratory tests that do not necessarily accurately reflect patients' day-to-day physical functioning.

Irritability in Recovered Bipolar Disorder Patients Linked to Greater Morbidity, Depression Recurrence

Irritability in Recovered Bipolar Disorder Patients Linked to Greater Morbidity, Depression Recurrence

Delayed depressive recovery occurred more in depressed patients with current irritability.

Cognition and White Matter Alterations in Schizophrenia, Bipolar Disorder

Cognition and White Matter Alterations in Schizophrenia, Bipolar Disorder

Direct comparison of white matter tracts between individuals with schizophrenia or bipolar disorder has not been performed to date.

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

Bipolar disorder and schizophrenia are characterized by significant genetic overlap, as well as significant clinical presentation overlap.

Cortical Molecular Markers Differentiate Psychotic, Bipolar Disorders

Cortical Molecular Markers Differentiate Psychotic, Bipolar Disorders

The researchers quantified the transcript levels of GAD67, parvalbumin, somastatin, and Lhx6 in the prefrontal cortex.

Psychotropic Drug Indications

Drug comparisons for mood disorders such as bipolar disorder, major depressive disorder, treatment resistant depression, premenstrual dysphoric disorder, and others.

Average of 6 Years Between Onset and Diagnosis of Bipolar Disorder

Average of 6 Years Between Onset and Diagnosis of Bipolar Disorder

Researchers found that many patients have disruptive symptoms for years before they receive proper treatment.

Study Links Acute Mania With Antibiotic Usage

Study Links Acute Mania With Antibiotic Usage

Investigators examined antibiotic use in patients with bipolar disorder, schizophrenia, and major depressive disorder.

Smoking Reduction Linked to Reduced Suicidality in Patients With Psychotic Conditions

Smoking Reduction Linked to Reduced Suicidality in Patients With Psychotic Conditions

At 12 months, researchers found a significant association between smoking reduction and suicidality.

Aberrant Reward Processing Likely Precedes Psychotic Disorders

Aberrant Reward Processing Likely Precedes Psychotic Disorders

Genetic risk for psychosis influences reward processing in healthy adolescents.

Bipolar Disorder Linked With Gene Expression in Unexpected Brain Region

Bipolar Disorder Linked With Gene Expression in Unexpected Brain Region

New findings underline the potential importance of signaling pathways in the striatum for understanding bipolar disorder pathophysiology.

Exposure to Stressful Triggers Increases Risk for Violent Criminality Irrespective of Psychiatric Condition

Exposure to Stressful Triggers Increases Risk for Violent Criminality Irrespective of Psychiatric Condition

The largest 7-day absolute risk of criminal violence was observed after exposure to violence in patients diagnosed with schizophrenia, bipolar disorder, as well as in unaffected individuals.

Following an Episode of Mania, Adults With Bipolar Disorder at Equal Risk for Depression or Anxiety

Following an Episode of Mania, Adults With Bipolar Disorder at Equal Risk for Depression or Anxiety

Bipolar disorder (BD) is typically characterized by recurrent episodes of mania and depression, but the connection between BD and anxiety needs to be considered.

What Neuroimaging Can Teach us About Depression

What Neuroimaging Can Teach us About Depression

Neuroimaging studies have shown several neurophysiological substrates for depression: An overview by Theodore Henderson, MD, PhD.

CDC Report: Jobs With the Highest Suicide Rates

CDC Report: Jobs With the Highest Suicide Rates

Events that happen in childhood and adolescence can predispose individuals to suicidal behavior.

Which Came First, the Cigarette or the Psychiatric Diagnosis?

Which Came First, the Cigarette or the Psychiatric Diagnosis?

University of Washington Tobacco Scholar Joseph Cerimele, MD, MPH, discusses the relationship between smoking and psychiatric illness.

Improving Muscular Fitness May Benefit People With Bipolar Disorder

Improving Muscular Fitness May Benefit People With Bipolar Disorder

Physical rehabilitation has the potential to improve the performance of daily activities in individuals with bipolar disorder.

Do Mobile Applications Have a Place in Managing Bipolar Disorder?

Do Mobile Applications Have a Place in Managing Bipolar Disorder?

Great potential exists for using objective smartphone data to discriminate between depressive and manic states in patients with bipolar disorder.

Increased Incidence of Comorbid Bipolar Disorder and Asthma

Increased Incidence of Comorbid Bipolar Disorder and Asthma

Research identifies high comorbidity rates between these 2 distinct diseases with underlying inflammation dysfunction.

Brain Abnormalities May Be Biomarkers for Bipolar Disorder

Brain Abnormalities May Be Biomarkers for Bipolar Disorder

Research in recent decades has found structural brain abnormalities in patients with bipolar disorder, but such observations had not been translated into objective and clinically useful biomarkers.

Theory of Mind Decoding Impairment Associated With Mania in Bipolar Disorder

Theory of Mind Decoding Impairment Associated With Mania in Bipolar Disorder

Theory of Mind refers to the ability to assign mental states to oneself and others based on social cues such as tone of voice and facial expressions.

Genetic Discovery Could Lead to Development of New Bipolar Meds

Genetic Discovery Could Lead to Development of New Bipolar Meds

Abnormal variations in the gene PDE10A19 might impact signaling of a messaging pathway responsible for learning, memory.

Better Diet, Exercise Can Lead to Behavioral Improvements

Better Diet, Exercise Can Lead to Behavioral Improvements

Feasible opportunities for healthy diet and activity linked to intentions, behaviors, and BMI.

Psychotic and Bipolar Disorder Most Predict Suicide After Prior Self-Harm

Psychotic and Bipolar Disorder Most Predict Suicide After Prior Self-Harm

Individuals with bipolar disorder or psychosis were 6 times more likely to die by suicide after prior self-harm.

How Nutritional Interventions Can Help Improve Mental Illnesses

How Nutritional Interventions Can Help Improve Mental Illnesses

Although not usually considered as part of primary treatment, nutrition addresses the crucial link between food and brain functioning.

Significant Treatment Gaps Exist for Depression Patients

Significant Treatment Gaps Exist for Depression Patients

Results from a new survey suggest that significant gaps exist in the treatment for adults in the US with major depressive disorder.

Can New Class of Mood Disorder Drugs Also Treat Chronic Pain?

Can New Class of Mood Disorder Drugs Also Treat Chronic Pain?

New research suggests that a group of drugs being developed for mood disorders could also relieve chronic pain.

CBT, Medication Have Same Efficacy for Treating Depression

CBT, Medication Have Same Efficacy for Treating Depression

For adults, similar efficacy for cognitive behavioral therapy and antidepressants.

Mood Stabilizer May Inhibit Coagulation

Mood Stabilizer May Inhibit Coagulation

Carbamazepine co-treatment linked to subtherapeutic anticoagulative effect of warfarin.

Quantitative Measurement in Psychiatry and Personalized Medicine

Quantitative Measurement in Psychiatry and Personalized Medicine

Therapeutic drug monitoring is vastly underused in psychiatry but could better inform clinical decision-making.

Paroxetine Use in Pregnancy Linked to Defects

Paroxetine Use in Pregnancy Linked to Defects

Increased risk of any major congenital malformations, major cardiac malformations.

WHO Opposes Chinese Request to Restrict Access to Ketamine

WHO Opposes Chinese Request to Restrict Access to Ketamine

China's U.N. delegation has argued that ketamine is a health risk when it is used in a recreational fashion.

Parents Influence Risk of Psychotic Symptoms in Kids on Stimulants

Parents Influence Risk of Psychotic Symptoms in Kids on Stimulants

Findings presented for children of parents with major mood and psychotic disorders.

Implications of the Mixed Features Specifier

Implications of the Mixed Features Specifier

The mixed features specifier identifies a subpopulation that is often misdiagnosed.

Antidepressant Treatment May Increase Mania, Bipolar Risk

Antidepressant Treatment May Increase Mania, Bipolar Risk

Significant association seen in SSRIs and venlafaxine in unipolar depression.

Gene Variant Linked to Psychotic Symptoms of Bipolar Disorder

Gene Variant Linked to Psychotic Symptoms of Bipolar Disorder

A team of researchers have linked a genetic variant of the SNX7 gene with both elevated levels of kynurenic acid and the disease symptoms of bipolar disorder.

'Rescued' Drug Could Be Safer Treatment for Bipolar Disorder

'Rescued' Drug Could Be Safer Treatment for Bipolar Disorder

An abandoned drug for stroke treatment may provide a safer treatment than lithium in treating bipolar disorder.

Proteins Could be Potential Bipolar Disorder Biomarkers

Proteins Could be Potential Bipolar Disorder Biomarkers

There was a significant difference in six proteins in those with bipolar I depression compared to the control group.

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