Bipolar Disorder Archive
Researchers characterized the psychopathological features in patients with type II bipolar disorder who experienced treatment-emergent mania after exposure to antidepressants.
Patients with type I bipolar disorder had significantly higher fasting triglyceride levels (121.7 mg/dL vs 87.0 mg/dL, P <.01).
Individuals with depressive residual symptoms between episodes may have more of a negative course of illness.
These findings challenge existing concerns about the association of light therapy with manic switching and may be useful for clinicians in developing treatment strategies for patients with bipolar disorder.
Bipolar disorder (31.9%), depression (19.8%), schizophrenia (14.2%), and anxiety disorders (9.1%) were the most common mental health issues reported. Approximately 13% of evacuees with a mental health concern reported a history of post-traumatic stress disorder.
Successful management of both the manic and depressive states in bipolar disorder has been difficult to achieve, despite a broad range of pharmacologic treatments available.
Michael Thase, MD, comments on the potential for lithium in drinking water as a psychiatric prophylactic agent.
Investigators seek the association between psychosis and complication risk after total joint arthroplasty.
Exploring Safe and Effective Treatments for Bipolar Depression: Transcranial Direct Current Stimulation
Transcranial direct current stimulation may be an effective add-on treatment for bipolar depression.
The frequent comorbidity of bipolar disorder and alcohol use disorder presents a significant challenge for clinicians managing patients with these conditions.
Safety and efficacy of lurasidone monotherapy were assessed in children and adolescents with bipolar I depression.
The Oregon Foundation for Reproductive Health recommends that all medical providers ask all female patients of reproductive age if they plan to become pregnant in the next year.
Patients with bipolar I disorder without relapse after 1 year of first treatment had improved neurocognitive functioning.
Abstinence-contingent incentives improved smoking cessation outcomes among economically disadvantaged smokers with mental illness.
Bipolar disorder and borderline personality disorder reflect alternate expressions of the same underlying disorder.
The benefits of psychoeducation for patients with bipolar disorder were mediated by perceived change in illness.
Venlafaxine was superior to lithium in reducing symptoms of both bipolar II depression and anxiety.
A schizophrenia-related polygenic-risk score association gradient was identified across bipolar disorder phenotypes.
The severity of psychotic symptoms in patients with bipolar affective disorder correlated inversely with the response to lithium therapy.
Patients with schizophrenia-spectrum disorders had higher odds of being aggressive than people with bipolar disorder with a recent manic episode.
The ability to track ingestion of medications prescribed for mental illness may be useful for some patients.
Comorbid anxiety disorders among patients with depression or bipolar disorder were not associated with suicide attempts.
Inclusion of supportive elements such as rehabilitation may help drive translation of cognitive improvements to broad functional measures.
Researchers evaluated the safety and efficacy of lurasidone in children and adolescents with bipolar depression.
Dopamine dysfunction underlies the pathoetiology of psychosis in both bipolar disorder and schizophrenia.
Asenapine decreases the time to recurrence of manic and depressive episodes among patients with bipolar I disorder.
Bright light therapy might be effective for the treatment of bipolar depression.
People with both bipolar disorder and ADHD have similar neurocognitive profiles compared with people with only bipolar disorder.
Olanzapine was shown to be effective among patients with acute mania associated with bipolar I disorder.
Lithium is the only medication to demonstrate an antisuicidal effect over and above its action on mood episodes in bipolar disorder.
An M1-like proinflammatory state is associated with a poor response to antidepressant treatment in bipolar depression with evidence suggesting increased production of cytokines in patients with mood disorders.
Ketamine improves social function and academic performance in juvenile patients with bipolar disorder with a fear of harm phenotype.
For patients with bipolar disorder and major depressive disorder, reduction in dose of antipsychotic medication could lead to an increased rate of hospitalization.
Mixed state does not increase the risk for suicidal behavior beyond the risk associated with the depressive component.
Children and adolescent offspring of patients with schizophrenia demonstrate more attenuated psychotic symptoms.
Psychosis in patients with bipolar disorder was not associated with worse clinical or functional outcomes.
Lithium response may be predicted with better accuracy by a new model.
Mixed and psychotic features and comorbid anxiety disorder were associated with poor treatment response in bipolar disorder.
The risk for mood disorders increases with the more sugar consumed from beverages and food.
Bipolar disorder in youth does not exhibit a cognitive worsening over time.
New bipolar I disorder treatment Abilify Maintena is only required once a month.
Childhood trauma modulates the effects of bipolar disorder on the amygdala and hippocampus by causing an increase in the volumes of gray matter.
Pregnant women with bipolar disorder receiving psychotropic medication did not experience less functional impairment and symptom burden.
Bipolar disorder probability in the offspring of a parent with BP was assessed by a risk calculator.
Bipolar disorder was connected to both sexual distress and overall quality of life.
In bipolar disorder, neurocognitive impairment needs to be considered a therapeutic clinical target to improve psychosocial functioning.
Manic relapse in bipolar disorder is connected to thyroid disease.
Bipolar disorder mood relapse episodes were delayed with risperidone long-acting injection.
Bipolar disorder treatment with lamotrigine during pregnancy may also prevent postpartum depressive episodes.
Depressed patients with diagnoses that ultimately converted to bipolar disorder had been diagnosed with depression earlier.
Emotional stability assessed in late adolescence is inversely associated with serious mental illness.
Neither bipolar disorder nor lithium treatment was associated with increased cancer incidence.
The burden of illness associated with bipolar disorder warrants early preemption.
Irritability may have wide-ranging impacts on symptomatic, functional, and social elements of quality of life.
Careful monitoring of thyroid function is necessary for patients undergoing lithium therapy.
Patients with bipolar disorder saw their quality of life affected by depression, irritability, and other psychiatric conditions.
Bipolar disorder mental health mobile apps containing "wishlists" might not adequately meet consumer needs.
Schizophrenia, mood disorders, and diabetes were among the top 20 conditions with the highest all-cause 30-day readmission rates.
Two OTC supplements may improve brain function and mood control in patients diagnosed with bipolar disorder.
Lithium treatment was not associated with the overall cancer risk in Swedish patients with bipolar disorder in the age group 50-84 years.
Patients discharged with a mood stabilizer and an atypical antipsychotic had the lowest rehospitalization rate.
Immune dysfunction may mediate the link between bipolar disorder and medical comorbidities.
In a new study, teens and young adults with bipolar disorder who had attempted suicide had slightly less volume and activity in areas of the brain that regulate emotion and impulses.
Delays in treatment for psychosis can be associated with poorer outcomes.
While lithium has been the mainstay of treatment for decades, several other classes of medication have recently been used with varying degrees of success.
Atypical antipsychotic adjunctive therapy to mood stabilizers may be more effective than mood stabilizer monotherapy.
For the acute treatment of manic or mixed episodes in bipolar I disorder, the recommended starting and treatment dose is now 5-10mg twice daily.
This study included Medicaid patients taking medications to treat bipolar disorder, schizophrenia, or major depression with psychosis.
Lithium prescription rates for patients with bipolar disorder have declined during the last decade.
Group psychoeducation is a low-cost psychological intervention with specific clinical benefits in early bipolar disorder, if the focus of care is preventing future mania relapse and improving self-management, interpersonal function, and support.
The Mood Zoom questionnaire asks users to rate anxiety, elation, sadness, anger, irritability, and energy on a 7-point Likert scale
Programs conducted in early stages of bipolar disorder to improve cognition and functioning may boost cognitive reserve and thus, help prevent cognitive decline.
One line of future research in this area will be examining whether dorsal attention network connectivity predicts behavioral performance and emotional reactivity.
Approximately 2.5% of people worldwide are estimated to have bipolar spectrum disorders, which are a significant cause of neuropsychiatric disability.
Dr. Scott Zeller suggests it is time to move away from emergency intramuscular haloperidol.
Patients with comorbid bipolar disorder and ADHD may benefit from methylphenidate treatment, if it can be done without incurring the risk of mania.
Intra-subject variability in reaction time (ISVRT) is viewed as a promising behavioral endophenotype for bipolar disorder.
Until now, the majority of postmortem research that has examined functionally related gene sets has been limited to a single disorder or region of the brain.
By using the Washington Early Recognition Center Affectivity and Psychosis (WERCAP) questionnaire, investigators accurately predicted bipolar disorder or schizophrenia in more than 85% of patients.
Findings suggest that in families with 2 generations of direct progenitors with bipolar disorder, an increase in bipolar disorder severity in future generations is likely.
Treatment initiated in the early stages of bipolar disorder was found more effective than treatment in later stages.
Interaction of Proline and COMT Genotype Influences Negative Symptoms in Schizophrenia & Bipolar Disorder
The authors explored whether valproate (VPA) treatment effects vary by catechol-O-methyltransferase (COMT) genotype.
Brain-derived Neurotrophic Factor and its Precursor proBDNF as Diagnostic Biomarkers for Mood Disorders
mBDNF/proBDNF ratio could potentially serve as a novel biomarker for mood disorders.
Insights from the Global Burden of Disease Study 2013
The immune system dysregulation may lead to or exacerbate neuropsychiatric conditions such as bipolar disorder.
Until now, assessment of aerobic exercise capacity included expensive and time-consuming laboratory tests that do not necessarily accurately reflect patients' day-to-day physical functioning.
Irritability in Recovered Bipolar Disorder Patients Linked to Greater Morbidity, Depression Recurrence
Delayed depressive recovery occurred more in depressed patients with current irritability.
Direct comparison of white matter tracts between individuals with schizophrenia or bipolar disorder has not been performed to date.
Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia
Bipolar disorder and schizophrenia are characterized by significant genetic overlap, as well as significant clinical presentation overlap.
The researchers quantified the transcript levels of GAD67, parvalbumin, somastatin, and Lhx6 in the prefrontal cortex.
Researchers found that many patients have disruptive symptoms for years before they receive proper treatment.
Investigators examined antibiotic use in patients with bipolar disorder, schizophrenia, and major depressive disorder.
At 12 months, researchers found a significant association between smoking reduction and suicidality.
Genetic risk for psychosis influences reward processing in healthy adolescents.
New findings underline the potential importance of signaling pathways in the striatum for understanding bipolar disorder pathophysiology.
Exposure to Stressful Triggers Increases Risk for Violent Criminality Irrespective of Psychiatric Condition
The largest 7-day absolute risk of criminal violence was observed after exposure to violence in patients diagnosed with schizophrenia, bipolar disorder, as well as in unaffected individuals.
Bipolar disorder (BD) is typically characterized by recurrent episodes of mania and depression, but the connection between BD and anxiety needs to be considered.
Neuroimaging studies have shown several neurophysiological substrates for depression: An overview by Theodore Henderson, MD, PhD.
Events that happen in childhood and adolescence can predispose individuals to suicidal behavior.
University of Washington Tobacco Scholar Joseph Cerimele, MD, MPH, discusses the relationship between smoking and psychiatric illness.
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Psychiatry Advisor Articles
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