Bipolar Depression

Better Outcomes With Lithium vs Quetiapine for Early Manic Episodes of Bipolar Disorder

Better Outcomes With Lithium vs Quetiapine for Early Manic Episodes of Bipolar Disorder

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Australian investigators found significant differences in early results from different treatments for bipolar disorder.

Depression Treatment May Benefit from Use of Ketamine

Depression Treatment May Benefit from Use of Ketamine

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Ketamine can provide acute benefits for treatment-resistant depression, bipolar depression, and major depressive disorder with suicidal ideation.

Early Bipolar Depression Response to Lurasidone Treatment

Early Bipolar Depression Response to Lurasidone Treatment

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Bipolar depression treatment response to lurasidone between baseline and week 2 indicates later treatment success.

Bipolar II Depression: No Difference Between Monotherapy and Combined Therapy

Bipolar II Depression: No Difference Between Monotherapy and Combined Therapy

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Bipolar II depression therapy options revealed no significant differences in switch rate or treatment relapse.

Suicidal Ideation in Bipolar Depression: A Potential New Treatment

Suicidal Ideation in Bipolar Depression: A Potential New Treatment

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A new agent would be the first oral treatment for suicidal behavior in patients with bipolar depression.

Different Clinical Outcomes in Bipolar Depression Based on Dosage

Different Clinical Outcomes in Bipolar Depression Based on Dosage

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There are clear disadvantages to prescribing higher rather than lower doses of SGAs.

Does Methylphenidate Lead to Treatment-Emergent Mania?

Does Methylphenidate Lead to Treatment-Emergent Mania?

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Patients with comorbid bipolar disorder and ADHD may benefit from methylphenidate treatment, if it can be done without incurring the risk of mania.

Searching for Novel Endophenotypic Markers for Bipolar Disorder

Searching for Novel Endophenotypic Markers for Bipolar Disorder

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Intra-subject variability in reaction time (ISVRT) is viewed as a promising behavioral endophenotype for bipolar disorder.

Gene Sets Altered Across Brain Regions in Schizophrenia, Bipolar Disorder & MDD

Gene Sets Altered Across Brain Regions in Schizophrenia, Bipolar Disorder & MDD

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Until now, the majority of postmortem research that has examined functionally related gene sets has been limited to a single disorder or region of the brain.

Bipolar and Schizophrenia Disorders Accurately Predicted With WERCAP Sections

Bipolar and Schizophrenia Disorders Accurately Predicted With WERCAP Sections

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By using the Washington Early Recognition Center Affectivity and Psychosis (WERCAP) questionnaire, investigators accurately predicted bipolar disorder or schizophrenia in more than 85% of patients.

Brain-derived Neurotrophic Factor and its Precursor proBDNF as Diagnostic Biomarkers for Mood Disorders

Brain-derived Neurotrophic Factor and its Precursor proBDNF as Diagnostic Biomarkers for Mood Disorders

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mBDNF/proBDNF ratio could potentially serve as a novel biomarker for mood disorders.

6-minute Walk Test Offers Insight Into Global Functioning Among Patients With Bipolar Disorder

6-minute Walk Test Offers Insight Into Global Functioning Among Patients With Bipolar Disorder

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Until now, assessment of aerobic exercise capacity included expensive and time-consuming laboratory tests that do not necessarily accurately reflect patients' day-to-day physical functioning.

Irritability in Recovered Bipolar Disorder Patients Linked to Greater Morbidity, Depression Recurrence

Irritability in Recovered Bipolar Disorder Patients Linked to Greater Morbidity, Depression Recurrence

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Delayed depressive recovery occurred more in depressed patients with current irritability.

Cognition and White Matter Alterations in Schizophrenia, Bipolar Disorder

Cognition and White Matter Alterations in Schizophrenia, Bipolar Disorder

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Direct comparison of white matter tracts between individuals with schizophrenia or bipolar disorder has not been performed to date.

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

Psychosocial and Demographic Predictors of Depression Among Individuals With Bipolar Disorder and Schizophrenia

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Bipolar disorder and schizophrenia are characterized by significant genetic overlap, as well as significant clinical presentation overlap.

Bipolar Disorder Linked With Gene Expression in Unexpected Brain Region

Bipolar Disorder Linked With Gene Expression in Unexpected Brain Region

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New findings underline the potential importance of signaling pathways in the striatum for understanding bipolar disorder pathophysiology.

Following an Episode of Mania, Adults With Bipolar Disorder at Equal Risk for Depression or Anxiety

Following an Episode of Mania, Adults With Bipolar Disorder at Equal Risk for Depression or Anxiety

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Bipolar disorder (BD) is typically characterized by recurrent episodes of mania and depression, but the connection between BD and anxiety needs to be considered.

What Neuroimaging Can Teach us About Depression

What Neuroimaging Can Teach us About Depression

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Neuroimaging studies have shown several neurophysiological substrates for depression: An overview by Theodore Henderson, MD, PhD.

CDC Report: Jobs With the Highest Suicide Rates

CDC Report: Jobs With the Highest Suicide Rates

Events that happen in childhood and adolescence can predispose individuals to suicidal behavior.

Patients on Lithium Are Significantly Less Likely to Harm Themselves

Patients on Lithium Are Significantly Less Likely to Harm Themselves

Patients with bipolar disorder taking lithium have lower rates of self-injury.

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