Chemical in Plastic Containers Linked to Autism

the Psychiatry Advisor take:

A material often used in the manufacture of plastic food and beverage containers, bisphenol-A (BPA), may be linked to autism spectrum disorder.

T. Peter Stein, PhD, of Rowan University School of Osteopathic Medicine in Stratford, N.J., and colleagues examined urine specimens of 46 children with autism and another 52 healthy children. They were looking for chemicals found in the urine.

A metabolomic analysis found that metabolities and total BPA excreted by the children with autism was three times higher than in the control group, the researchers reported in the journal Autism Research. They add that the study indicates that children with autism may metabolize BPA differently than healthy children.

BPA becomes water soluble when it is bound to glucose in the liver in a process known as glucuronidation. Conversion to a glucuronide and then excretion of the glucuronide in the urine is a major pathway for removing toxins from the body.

“The key point is that the study seems to link BPA to autism and creates an open area for further research,” Stein said. “One implication of our study is that there might be a benefit to reducing BPA exposure for pregnant women and for children with autism.”

Chemical in Plastic Containers Linked to Autism
Chemical in Plastic Containers Linked to Autism

A newly published study is the first to report an association between bisphenol-A (BPA), a common plasticizer used in a variety of consumer food and beverage containers, with autism spectrum disorder (ASD) in children. The study, by researchers at Rowan University School of Osteopathic Medicine and Rutgers New Jersey Medical School, shows that BPA is not metabolized well in children with ASD. The research appears online in Autism Research.

The research team examined urine specimens from 46 children with ASD and 52 healthy control children for both free BPA and total BPA concentrations. Like many chemicals, BPA becomes water soluble when it is bound to glucose in the liver - a process called glucuronidation. Conversion to a glucuronide and then excretion of the glucuronide in the urine is a major pathway for removing toxins from the body.

READ FULL ARTICLE From News Medical
Loading links....
You must be a registered member of Psychiatry Advisor to post a comment.

Sign Up for Free e-newsletters