ANZEMET INJECTION Rx
Generic Name and Formulations:
Dolasetron mesylate 20mg/mL; IV inj.
Indications for ANZEMET INJECTION:
Prevention and treatment of post-op nausea & vomiting.
Give by IV inj, either undiluted 100mg over 30 seconds or diluted to 50mL and infused over up to 15 mins. ≥16yrs: Prevention: 12.5mg given as a single dose about 15 mins before stopping anesthesia. Treatment: 12.5mg as soon as needed.
May give by IV inj as in adult dose, or may be mixed into apple or apple-grape juice and taken orally (timing and doses are different; see full labeling). <2yrs: not established. 2–16yrs: Prevention: 0.35mg/kg IV (max 12.5mg) given as single dose about 15 mins before stopping anesthesia; or, 1.2mg/kg (max 100mg) mixed into apple or apple-grape juice and taken orally within 2hrs before surgery. Treatment: 0.35mg/kg IV as soon as needed.
Inj soln administered by IV: Prevention of nausea & vomiting associated with emetogenic cancer chemotherapy, including initial and repeat courses in adults and children.
Increased risk of developing QTc, PR and QRS interval prolongation. Avoid in patients with congenital QT syndrome, hypokalemia, hypomagnesemia, complete heart block or risk of (unless paced). Correct electrolyte imbalances prior to therapy. Monitor ECG periodically. CHF. Bradycardia. Pre-existing conduction abnormalities and underlying structural heart disease. Sick sinus syndrome. Atrial fibrillation with slow ventricular response. Recent MI. Renal impairment. Elderly. Pregnancy (Cat.B). Nursing mothers.
Caution with drugs which can prolong ECG intervals (eg, verapamil, flecainide, quinidine), diuretics, and with cumulative high-dose anthracycline therapy. Serotonin syndrome possible with concomitant serotonergic drugs (eg, SSRIs, SNRIs). Potentiated by cimetidine, atenolol (IV dolasetron). Antagonized by rifampin.
Selective 5-HT3 receptor antagonist.
Headache, dizziness, pain, fatigue, diarrhea, bradycardia, tachycardia, dyspepsia, chills/shivers, ECG changes, 2nd or 3rd-degree AV block; serotonin syndrome (discontinue if occurs).
Tabs—5; Single-use vials (100mg/5mL)—1; Single-use vials (12.5mg/0.625mL)—6; Multidose vial (500mg/25mL)—1
Psychiatry Advisor Articles
- ADHD, Comorbid Bipolar Disorder Share Similar Neurocognitive Profiles
- Anxiety Prevention Interventions: How Effective Are They?
- Antidepressant Use and Dementia Risk in the Elderly
- Sleep Apnea Implant Device Receives FDA Approval
- No Evidence of Personality Changes Prior to Developing Cognitive Impairment, Dementia
- Suicidal Behavior, Thoughts Associated With Perfectionist Tendencies
- Physicians Spend Nearly 6 Hours on EHR Tasks Per Day
- CBT, Acceptance Commitment Therapy Helpful for Those With Chronic Pain
- Depression Reduced by Social Belonging, Feelings of Inclusion
- Sleep Disturbance May Be Causal Factor in Psychotic Experiences
- Duration of Untreated Depression Predicts Depression Severity
- Asenapine Prevents Recurrence of Mood Events in Bipolar Disorder
- Cognitive Dysfunction a Sign of Prodromal Parkinson Disease
- ACOG Update: Marijuana Use Discouraged During Pregnancy, Breastfeeding
- Bipolar Depression Benefits From Midday Bright Light Therapy