Antipsychotics

Personalized Treatment With Second vs. First Generation Antipsychotics

Personalized Treatment With Second vs. First Generation Antipsychotics

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The primary outcome in this study was the change in total quality-of-life scores from baseline to week 24 after patients were randomly assigned to a treatment group.

Patients on Antipsychotics Rarely Screened for Diabetes

Patients on Antipsychotics Rarely Screened for Diabetes

70% of severely mentally ill patients on Medicaid were not tested for diabetes, despite having a two to three times greater risk.

Long-Term Antipsychotic Use Common in Alzheimer's Patients

Long-Term Antipsychotic Use Common in Alzheimer's Patients

Guidelines, however, say that antipsychotics should only be used short term for severe psychotic symptoms and agitation.

Treating Parkinson's Psychosis With Antipsychotics May Boost Death Risk

Treating Parkinson's Psychosis With Antipsychotics May Boost Death Risk

PDP patients treated with antipsychotics were four times as likely to died following three to six months of treatment than those not on the meds.

Majority of Dementia Patients Take Multiple Psychotropic Drugs

Majority of Dementia Patients Take Multiple Psychotropic Drugs

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Dementia patients who were younger, female and lived in nursing homes were most associated with psychotropic polypharmacy.

FDA Approves New Schizophrenia, Depression Drug Brexpiprazole

FDA Approves New Schizophrenia, Depression Drug Brexpiprazole

Rexulti (brexpiprazole), from Otsuka and Lundbeck, is approved as a monotherapy in schizophrenia and an adjunct in patients with major depression.

Smoking May Boost Psychosis Risk

Smoking May Boost Psychosis Risk

Almost 60% of people diagnosed with a first episode of psychosis were also smokers.

FDA Issues Warning About Counterfeit Benzodiazepine Sold Online

FDA Issues Warning About Counterfeit Benzodiazepine Sold Online

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WHO identifies over 700 adverse event reports from Africa of patients taking what they thought was diazepam but was actually haloperidol.

Lowering Antipsychotic Dose Safe For Older Schizophrenia Patients

Lowering Antipsychotic Dose Safe For Older Schizophrenia Patients

Patients with late life schizophrenia who had their antipsychotic dose reduced had fewer side effects without sacrificing medication efficacy.

Use of Antipsychotics By Teens, Young Adults Rises

Use of Antipsychotics By Teens, Young Adults Rises

Males were more likely to be given antipsychotics than females, and among young adults given the drugs, depression was most common diagnosis.

Mortality Risk Increased for Parkinson's Patients on Antipsychotics

Mortality Risk Increased for Parkinson's Patients on Antipsychotics

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Parkinson's patients who took any antipsychotic were more than twice as likely to die within 180 days than those not on one.

First Three-Month-Long Injectable Antipsychotic Now Available

First Three-Month-Long Injectable Antipsychotic Now Available

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Invega Trinza is dosed once every four months following monthly treatment of Invega Sustenna for at least four months.

Declassifying Psychedelic Drugs to Examine Their Treatment Potential

Declassifying Psychedelic Drugs to Examine Their Treatment Potential

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One psychiatrist is calling on authorities to declassify psychedelic drugs to study their therapeutic potential for mental illnesses.

Long-Acting Injectable Antipsychotics Lead To Better Results Than Oral Versions

Long-Acting Injectable Antipsychotics Lead To Better Results Than Oral Versions

Patients taking a long-acting injectable antipsychotic had better medication adherence and control of symptoms than peers taking a pill version.

Patients, Psychiatrists Frustrated With Existing Schizophrenia Meds

Patients, Psychiatrists Frustrated With Existing Schizophrenia Meds

In survey, patients with schizophrenia and psychiatrists both expressed displeasure over efficacy and side effects of current antipsychotics.

Parkinson's Disease Psychosis: Common, Yet Not Often Reported

Parkinson's Disease Psychosis: Common, Yet Not Often Reported

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PD psychosis is underreported and faces treatment challenges, though a new treatment on the horizon may change that.

Avoid Antipsychotics As First-Line Insomnia Therapy, Groups Say

Avoid Antipsychotics As First-Line Insomnia Therapy, Groups Say

A group of psychiatric associations is recommending that behavioral changes and other nonpharmacological interventions be used instead.

Some Antipsychotics Linked to Weight Gain in Children

Some Antipsychotics Linked to Weight Gain in Children

However, researchers found no weight gain in children and adolescents who took SSRI and SNRI antidepressants.

Some Psychiatric Drugs May Be Linked to Higher Homicide Risk

Some Psychiatric Drugs May Be Linked to Higher Homicide Risk

An study of people convicted of homicides found that using benzodiazepines was associated with a 45% increased risk of doing so.

Experimental Schizophrenia Drug Shows Promise in Phase II

Experimental Schizophrenia Drug Shows Promise in Phase II

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A Phase II trial of Intra-Cellular's ITI-007 shows improvement in negative symptoms of schizophrenia without side effects seen in other antipsychotics.

Questions Linger Over Long-Term Use of Psychiatric Drugs

Questions Linger Over Long-Term Use of Psychiatric Drugs

One Danish scientist argues that the benefits of psychiatric drugs have been exaggerated and their harms minimized.

FDA Approves First Three-Month-Long Injectable Antipsychotic

FDA Approves First Three-Month-Long Injectable Antipsychotic

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Invega Trinza, from Janssen, should be available to patients by mid-June.

Biomarkers Set To Advance Treatment of Psychiatric Disorders

Biomarkers Set To Advance Treatment of Psychiatric Disorders

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Ongoing research indicates that biomarkers can predict the efficacy of an antipsychotic or potential side effects in a patient.

High Cholesterol May Improve Cognition in Schizophrenia

High Cholesterol May Improve Cognition in Schizophrenia

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An evaluation of the CATIE trial finds high lipid levels may boost cognition in schizophrenia patients.

Biomarkers Identified to Predict Antipsychotic Response

Biomarkers Identified to Predict Antipsychotic Response

Measuring levels of cortisol and inflammation markers may help to determine if a patient will respond to an antipsychotic.

FDA Approves First Generics of Antipsychotic Abilify

FDA Approves First Generics of Antipsychotic Abilify

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Abilify (aripiprazole) has annual sales of nearly $8 billion.

Phase III Trial Supports Efficacy of Antipsychotic Brexpiprazole

Phase III Trial Supports Efficacy of Antipsychotic Brexpiprazole

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Brexpiprazole, thought to be a successor to aripiprazole (Abilify), could be approved by the FDA for schizophrenia in July.

More Than 1% of Preschoolers Given Psychiatric Medication

More Than 1% of Preschoolers Given Psychiatric Medication

Analysis of data from preschoolers on Medicaid shows nearly 1.2% of them received a prescription for ADHD, anxiety or depression.

The Underuse of Clozapine in Schizophrenia

The Underuse of Clozapine in Schizophrenia

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Although clozapine is often ignored by many clinicians, the antipsychotic should be considered for more patients.

Novel Antipsychotic Shows Beneficial Weight Effect

Novel Antipsychotic Shows Beneficial Weight Effect

ALKS 3831, developed by Alkermes, shows efficacy on par with olanzapine, but without the weight gain.

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