Antidepressant

Cytokine Levels May Predict SSRI Response in Children and Adolescents

Cytokine Levels May Predict SSRI Response in Children and Adolescents

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Elevated cytokine levels could help to identify children who are unlikely to respond to treatment with fluoxetine.

Mechanism of Rapid Antidepressant Effect of Alcohol Elucidated

Mechanism of Rapid Antidepressant Effect of Alcohol Elucidated

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Acute exposure to ethanol led to antidepressant and anxiolytic behaviors in rodents for up to 24 hours.

Researchers Report Antidepressant Bupropion Crosses Placenta

Researchers Report Antidepressant Bupropion Crosses Placenta

Effects of fetal exposure are yet to be determined.

Sertraline Prevents Depression Following Traumatic Brain Injury

Sertraline Prevents Depression Following Traumatic Brain Injury

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Approximately 80% of depressive episodes have their onset during the first six months following traumatic brain injury.

The Neuroanatomy of, and Cognitive Deficits in, Depression: A Brief Overview

The Neuroanatomy of, and Cognitive Deficits in, Depression: A Brief Overview

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Atrophy of numerous structures within the central nervous system has been observed in persons suffering from depression.

Augmentation With Antidepressants in Schizophrenia Treatment Appears Safe and Efficacious

Augmentation With Antidepressants in Schizophrenia Treatment Appears Safe and Efficacious

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In terms of depressive and negative symptoms, in the present meta-analysis, researchers estimate that 1 in 9 patients with schizophrenia will improve with add-on antidepressants.

Off-Label Prescription of Antidepressants on the Rise

Off-Label Prescription of Antidepressants on the Rise

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The most common off-label uses were for insomnia (10.2%) and pain (6.1%).

Meta-Analysis Indicates Antidepressants Ineffective in Children, Teens

Meta-Analysis Indicates Antidepressants Ineffective in Children, Teens

A systematic review showed that most antidepressants are ineffective, and sometimes risky, for children and teens.

Enhanced Effect of Antidepressants Seen With Nutritional Supplements

Enhanced Effect of Antidepressants Seen With Nutritional Supplements

Antidepressants were found to be more effective with the concomitant use of nutritional supplements.

Antidepressant Bupropion Linked To Less Weight Gain

Antidepressant Bupropion Linked To Less Weight Gain

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Having more information on the long-term impact of antidepressants on weight could reduce the risk of weight-related morbidity for a large population of adults with depression.

SSRIs Found Not To Increase Risk of Cardiac Events in Depression

SSRIs Found Not To Increase Risk of Cardiac Events in Depression

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Neither a specific antidepressant class nor individual drugs had any influence on the risk of stroke or transient ischemic attack over all of follow-up.

Improvements Needed in Treating Veterans With PTSD, Depression

Improvements Needed in Treating Veterans With PTSD, Depression

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The number and timing of follow-up psychotherapy visits may be inadequate to deliver evidence-based psychotherapy.

Can Subtyping Depressive Symptoms Predict Antidepressant Response?

Can Subtyping Depressive Symptoms Predict Antidepressant Response?

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Many clinicians have a working assumption that subtyping patients is a critical process relevant to antidepressant treatment selection.

Depressed Patients' Placebo Response May Predict Response to Real Therapy

Depressed Patients' Placebo Response May Predict Response to Real Therapy

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How a patient being treated for depression responds to a placebo may determine how well they will respond to real antidepressant therapy.

Antipsychotic Plus Antidepressant Helps Treatment-Resistant Depression

Antipsychotic Plus Antidepressant Helps Treatment-Resistant Depression

44% of depressed participants who received the antipsychotic aripiprazole in addition to an antispychotic achieved remission.

SSRI Antidepressant Found Unsafe For Adolescents

SSRI Antidepressant Found Unsafe For Adolescents

Suicidal ideation and behavior was seen in adolescents with major depression who took paroxetine.

No Long-Term Effects of Antidepressant Use During Pregnancy

No Long-Term Effects of Antidepressant Use During Pregnancy

However, researchers say there may be a link between antidepressants and postpartum hemorrhage.

SSRIs May Change Region of Brain

SSRIs May Change Region of Brain

In study, monkeys found to be depressed and given sertraline saw reduced volume in the brain's anterior cingulate cortex.

Antidepressant Use While Pregnant Tied to Lower Risk of Preterm Birth

Antidepressant Use While Pregnant Tied to Lower Risk of Preterm Birth

Women who were given antidepressants while pregnant were less like to give birth prematurely and deliver by Caesarean section.

Dispensing Errors Reported With Antidepressant Brintellix

Dispensing Errors Reported With Antidepressant Brintellix

No known use of the wrong drug, but prescribing, dispensing errors have been reported.

Atypical Depression Linked to Risk of Inflammation, Heart Disease

Atypical Depression Linked to Risk of Inflammation, Heart Disease

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Clinicians may want to consider referring atypical depression patients to a nutritionist to avoid inflammation and cardiac issues.

Antidepressant + NSAID Pain Reliever May Boost Brain Bleeding Risk

Antidepressant + NSAID Pain Reliever May Boost Brain Bleeding Risk

NSAID users were 60% more likely to suffer an intracranial hemorrhage within 30 days of starting an antidepressant.

New Compounds Could Bring Depression Relief in 24 Hours

New Compounds Could Bring Depression Relief in 24 Hours

New compounds, which target the neurotransmitter GABA, provided relief of symptoms within 24 hours in rats with fewer side effects than SSRIs.

Certain SSRI Antidepressants Linked to Birth Defects

Certain SSRI Antidepressants Linked to Birth Defects

Maternal use of paroxetine (Paxil) and fluoxetine (Prozac) was associated with a higher risk of birth defects, but not with sertraline (Zoloft).

Antidepressants, Parkinson's Med May Affect Morality, Decision-Making

Antidepressants, Parkinson's Med May Affect Morality, Decision-Making

The antidepressant citalopram and the Parkinson's med levodopa influenced how much pain people were willing to inflict on themselves or others.

SSRI Antidepressants Exacerbate Rapid Cycling in Bipolar Disorder

SSRI Antidepressants Exacerbate Rapid Cycling in Bipolar Disorder

Long-term continuation of SSRI antidepressants in people with rapid cycling led to more mood and depressive episodes.

Herbal Supplement May Cause Serious Side Effects When Taken With Antidepressants

Herbal Supplement May Cause Serious Side Effects When Taken With Antidepressants

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Side effects including anxiety, panic attacks, vomiting and aggression were reported when St. John's Wort and antidepressants were taken together.

SSRI Antidepressants Linked to Bone Fracture Risk in Menopausal Women

SSRI Antidepressants Linked to Bone Fracture Risk in Menopausal Women

Menopausal women who took an SSRI had a 76% higher risk of fracture after one year of use compared to women not taking an antidepressant.

Declassifying Psychedelic Drugs to Examine Their Treatment Potential

Declassifying Psychedelic Drugs to Examine Their Treatment Potential

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One psychiatrist is calling on authorities to declassify psychedelic drugs to study their therapeutic potential for mental illnesses.

New Drug Combo Involving Ketamine Shows Promise for Bipolar Depression

New Drug Combo Involving Ketamine Shows Promise for Bipolar Depression

A combination of the drugs D-cycloserine and lurasidone may prolong the antidepressant effects of ketamine, according to a small study.

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