There is no conclusive benefit to switching to a new antidepressant during nonresponse.
Elevated cytokine levels could help to identify children who are unlikely to respond to treatment with fluoxetine.
Acute exposure to ethanol led to antidepressant and anxiolytic behaviors in rodents for up to 24 hours.
Effects of fetal exposure are yet to be determined.
Approximately 80% of depressive episodes have their onset during the first six months following traumatic brain injury.
Atrophy of numerous structures within the central nervous system has been observed in persons suffering from depression.
In terms of depressive and negative symptoms, in the present meta-analysis, researchers estimate that 1 in 9 patients with schizophrenia will improve with add-on antidepressants.
The most common off-label uses were for insomnia (10.2%) and pain (6.1%).
A systematic review showed that most antidepressants are ineffective, and sometimes risky, for children and teens.
Antidepressants were found to be more effective with the concomitant use of nutritional supplements.
Having more information on the long-term impact of antidepressants on weight could reduce the risk of weight-related morbidity for a large population of adults with depression.
Neither a specific antidepressant class nor individual drugs had any influence on the risk of stroke or transient ischemic attack over all of follow-up.
The number and timing of follow-up psychotherapy visits may be inadequate to deliver evidence-based psychotherapy.
Many clinicians have a working assumption that subtyping patients is a critical process relevant to antidepressant treatment selection.
How a patient being treated for depression responds to a placebo may determine how well they will respond to real antidepressant therapy.
44% of depressed participants who received the antipsychotic aripiprazole in addition to an antispychotic achieved remission.
Suicidal ideation and behavior was seen in adolescents with major depression who took paroxetine.
However, researchers say there may be a link between antidepressants and postpartum hemorrhage.
In study, monkeys found to be depressed and given sertraline saw reduced volume in the brain's anterior cingulate cortex.
Women who were given antidepressants while pregnant were less like to give birth prematurely and deliver by Caesarean section.
No known use of the wrong drug, but prescribing, dispensing errors have been reported.
Clinicians may want to consider referring atypical depression patients to a nutritionist to avoid inflammation and cardiac issues.
NSAID users were 60% more likely to suffer an intracranial hemorrhage within 30 days of starting an antidepressant.
New compounds, which target the neurotransmitter GABA, provided relief of symptoms within 24 hours in rats with fewer side effects than SSRIs.
Maternal use of paroxetine (Paxil) and fluoxetine (Prozac) was associated with a higher risk of birth defects, but not with sertraline (Zoloft).
The antidepressant citalopram and the Parkinson's med levodopa influenced how much pain people were willing to inflict on themselves or others.
Long-term continuation of SSRI antidepressants in people with rapid cycling led to more mood and depressive episodes.
Side effects including anxiety, panic attacks, vomiting and aggression were reported when St. John's Wort and antidepressants were taken together.
Menopausal women who took an SSRI had a 76% higher risk of fracture after one year of use compared to women not taking an antidepressant.
One psychiatrist is calling on authorities to declassify psychedelic drugs to study their therapeutic potential for mental illnesses.
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