Generic Name and Formulations:
Disulfiram 250mg, 500mg; tabs.
Indications for ANTABUSE:
Adjunct in management of chronic alcoholic patients who want to remain sober.
Abstain for at least 12 hrs. Initially 500mg once daily for 1–2 weeks then 250mg once daily; max 500mg daily. Continue until patient develops basis for self-control.
Severe cardiovascular disease. Psychosis. Allergy to thiuram in pesticides and rubber. Concomitant metronidazole, paraldehyde, alcohol-containing products.
Never administer when in a state of alcohol intoxication. Advise family members of alcohol effect. Diabetes. Hypothyroidism. Epilepsy. Cerebral damage. Nephritis. Hepatic cirrhosis or insufficiency. Ethylene dibromide inhalation. Monitor hepatic function, electrolytes, blood, CBCs. Alcohol trial in patients >50yrs: not recommended. Pregnancy. Nursing mothers.
See Contraindications. Alcohol-like reaction to metronidazole, paraldehyde, alcohol-containing drugs and elixirs, some so-called alcohol-free beverages, tonics, foods, aftershave, back rubs. Potentiates phenytoin, oral anticoagulants, isoniazid.
Optic, peripheral and polyneuritis; peripheral neuropathy, drowsiness, rash, psychosis, hepatitis.
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