Alzheimer’s Disease

Exploring Possible Causes of Decreasing Dementia Rates In the US

Exploring Possible Causes of Decreasing Dementia Rates In the US

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Better management of cardiovascular risk factors and higher levels of education may have contributed to this improvement.

MRI May Help Identify Lewy Body Dementia vs Alzheimer's

MRI May Help Identify Lewy Body Dementia vs Alzheimer's

Someone whose hippocampus stayed the same size was nearly 6 times more likely to develop Lewy body dementia.

Gender-dependent Differences in Alzheimer Disease Diagnosis

Gender-dependent Differences in Alzheimer Disease Diagnosis

In 2016, an estimated 5.4 million US adults have Alzheimer disease.

Sundowning: Phenomenology, Pathophysiology, and Treatment Approaches

Sundowning: Phenomenology, Pathophysiology, and Treatment Approaches

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Sundowning is a complex multifactorial condition that has eluded rigorous understanding of its pathophysiological causes.

Alcohol Consumption and Alzheimer Disease: A Brief Update

Alcohol Consumption and Alzheimer Disease: A Brief Update

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Basic Research Findings for the Practicing Clinician

How Does BMI Affect Alzheimer's Risk?

How Does BMI Affect Alzheimer's Risk?

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Those with lower BMI showed higher levels of beta-amyloid, closely tied to the onset of Alzheimer's disease.

PET Imaging Can Assist In Identifying Alzheimer's Disease Stage

PET Imaging Can Assist In Identifying Alzheimer's Disease Stage

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The findings suggest that interactions between beta-amyloid and tau lead to neurodegeneration in Alzheimer's.

Vascular Intervention Appears Not To Affect Dementia Incidence

Vascular Intervention Appears Not To Affect Dementia Incidence

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Cases of all-cause dementia and Alzheimer's did not significantly differ between study groups, but vascular care is safe and may reduce incidence of non-Alzheimer's dementia.

Alzheimer Markers Detected in Healthy Individuals with Genetic AD Risk

Alzheimer Markers Detected in Healthy Individuals with Genetic AD Risk

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The effects of aggregate genetic AD risk are detectable before symptoms appear, even early in life.

CSF Biomarkers Improve Diagnosis in Patients with Psychiatric Disorders & Cognitive Symptoms

CSF Biomarkers Improve Diagnosis in Patients with Psychiatric Disorders & Cognitive Symptoms

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Distinguishing between psychiatric disorders and AD is crucial because of the differing prognosis and management of the two.

No Evidence for Transmission of Alzheimer Pathology Through Blood Transfusions

No Evidence for Transmission of Alzheimer Pathology Through Blood Transfusions

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If transmission of neurodegenerative diseases such as dementia of any type, AD, or PD does occur, it is rare.

Cannabinoids Reduce Intraneuronal Beta Amyloid Protein Levels

Cannabinoids Reduce Intraneuronal Beta Amyloid Protein Levels

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Tetrahydrocannabinol (THC) is the main active chemical ingredient found in cannabis and is a potent cannabinoid receptor (CB)-1 agonist.

Physical Activity During Midlife Influences Late Life Verbal Memory Performance

Physical Activity During Midlife Influences Late Life Verbal Memory Performance

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Modifiable risk factors (eg, smoking, hypertension, sedentary behavior, overweight/obesity, and social engagement) contribute to nearly half of documented dementia cases.

Leaky Blood-Brain Barrier Associated With Cognitive Decline in Early Alzheimer Disease

Leaky Blood-Brain Barrier Associated With Cognitive Decline in Early Alzheimer Disease

Cognitive test scores are negatively correlated with blood-brain barrier disruption in patients with early AD.

Could Alzheimer's Disease be Caused by Infections?

Could Alzheimer's Disease be Caused by Infections?

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Although inconclusive, late-onset Alzheimer's Disease could be triggered by infectious pathogens.

Homocysteine Levels Elevated in Alzheimer's Disease

Homocysteine Levels Elevated in Alzheimer's Disease

Researchers identified increased fibrinogen levels and amyloid-β deposits in the blood vessels and brain parenchyma of patients with Alzheimer's disease.

Novel Case: Alzheimer's Reported in HIV+ Patient

Novel Case: Alzheimer's Reported in HIV+ Patient

The case suggests that some patients with HIV and dementia may be misdiagnosed with HIV-associated brain disorders.

Improved Cognitive Assessment Test to Screen for Dementia

Improved Cognitive Assessment Test to Screen for Dementia

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Administration time for cognitive assessment screenings is currently suboptimal in many clinical settings.

Sensory Stimulation May Benefit Patients with Dementia

Sensory Stimulation May Benefit Patients with Dementia

Researchers identified 8 categories of sensory stimulation interventions that significantly influenced dementia.

White Matter Hyperintensities Predate Onset of Alzheimer's

White Matter Hyperintensities Predate Onset of Alzheimer's

White matter hyperintensity volume differences were seen 6 years before Alzheimer's symptoms.

Colonic Diverticular Disease May Increase Dementia Risk

Colonic Diverticular Disease May Increase Dementia Risk

Researchers found an elevated risk of dementia after adjustment for age, sex, and comorbidities.

Physical Activity Level Affects Rate of Cognitive Decline

Physical Activity Level Affects Rate of Cognitive Decline

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Declines in processing sleep and episodic memory were observed in those with low levels of activity.

Scientists Discover How Tau Affects Memory Loss In Dementia

Scientists Discover How Tau Affects Memory Loss In Dementia

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While scientists have long known that tau is involved in dementia, the way in which it hinders cognitive function has remained uncertain.

Blueberries May Help Prevent Effects of Alzheimer's

Blueberries May Help Prevent Effects of Alzheimer's

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There was improvement in cognitive performance and brain function in those who took the blueberry powder.

Intellectual Stimulation Advantageous in Alzheimer Disease

Intellectual Stimulation Advantageous in Alzheimer Disease

Higher educational level and increased cognitive activity has been associated with less amyloid deposition in APOE4 carriers.

Immune System May Play Greater Role in Alzheimer's Than Thought

Immune System May Play Greater Role in Alzheimer's Than Thought

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While many studies have explored the role of microglia in Alzheimer's, very few researchers have examined the role of the adaptive immune system.

Mental Stimulation May Delay Symptoms of Alzheimer's, But Not Its Cause

Mental Stimulation May Delay Symptoms of Alzheimer's, But Not Its Cause

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There is substantial evidence that mental stimulation in middle age helps to delay the onset of memory and thinking problems.

Urine Odor May Lead To Early Alzheimer's Identification

Urine Odor May Lead To Early Alzheimer's Identification

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The findings suggest that it may be possible to develop a non-invasive tool for early diagnosis of Alzheimer's disease.

Moderate Drinking May Reduce Mortality in Early-Stage Alzheimer's

Moderate Drinking May Reduce Mortality in Early-Stage Alzheimer's

Those who had 2 to 3 alcoholic drinks a day had a 77% lower risk of dying during the study period than those who had 1 or fewer drinks a day.

Exercise May Help Reverse Neurodegeneration

Exercise May Help Reverse Neurodegeneration

Participants' cardiorespiratory fitness improved by about 8%, and the greater the fitness improvements, the more growth in the cortical layer.

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