Low and High Serum Magnesium Levels Increase Risk for Dementia

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There was an increased risk of dementia associated with both low serum magnesium levels and high serum magnesium levels.
There was an increased risk of dementia associated with both low serum magnesium levels and high serum magnesium levels.

HealthDay News — Magnesium levels, either too high or too low, are associated with an increased risk of dementia, according to a study published online in Neurology.

Brenda CT Kieboom, MD, from the Erasmus MC-University Medical Center Rotterdam in the Netherlands, assessed serum magnesium levels in 9569 participants in the Rotterdam Study, who were free from dementia at baseline (1997-2008). Participants (mean age, 64.9 years; 56.6% women) were followed until January 1, 2015, to determine incident dementia.

The researchers found that over a median follow-up of 7.8 years, 823 participants were diagnosed with all-cause dementia

There was an increased risk of dementia associated with both low serum magnesium levels (≤0.79 mmol/L) and high serum magnesium levels (≥0.90 mmol/L) (hazard ratios, 1.32 and 1.30, respectively).

"As we are the first to study this association, our results warrant replication in other population-based studies," the authors write.

Reference

Kieboom BCT, Licher S, Wolters FJ, et al. Serum magnesium is associated with the risk of dementia [published online September 20, 2017]. Neuorology. doi:10.1212/WNL.0000000000004517

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