Alzheimer’s Disease and Dementia Archive
As the neurodegenerative processes of Alzheimer disease and Parkinson disease are different, early cognitive impairment also present differently in these diseases.
Given the frequent use of benzodiazepines among older people, even a small increase in absolute risk may be a serious matter on a population level.
While hundreds of published reports have made an argument for an association between Alzheimer disease and bacteria and viruses, the suggestion of a viral contribution to Alzheimer disease has not always been well received by the greater research community.
Phase 3 clinical trials for lanabecestat (Eli Lilly and AstraZeneca), an investigational Alzheimer disease treatment, are being discontinued for futility.
The lifetime risks of Alzheimer disease dementia vary considerably by age, gender, and the preclinical or clinical disease state.
There is a reduced risk for dementia for older Chinese adults actively participating in intellectual activities.
Public health strategies for preventing dementia should target socioeconomic gaps to reduce health disparities and protect the disadvantaged.
Multimarker inflammatory biosignatures are expected to facilitate diagnosis and predict treatment outcomes for various central nervous system disorders, particularly Alzheimer disease and major depressive disorder.
These results suggest that antipsychotic exposure has no impact on relative mortality.
The use of certain anticholinergic drugs may increase the risk of future dementia.
Using hearing aids may slow cognitive decline in later life.
These data support the importance of TBI preventative measures and proper management strategies for subsequent dementia.
The findings also suggested that more a more recent diagnosis of psychosis was a greater predictor of the development of dementia, as opposed to cases where patients had been living with psychotic disorder diagnoses for 10 years or more.
Patients with a phonemic advantage at baseline should be followed more closely with a higher index of suspicion for progression to Alzheimer disease.
Researchers concluded that the partnership did not accelerate the overall decline in antipsychotic medication use among study participants.
Investigators evaluated CSF Aβ1-42 levels obtained from individuals who presented no signs of cognitive dysfunction at enrollment and estimated the proximity of participants' age to their parents' age of AD symptom onset.
A study was conducted to assess potential beneficial effects of a lifestyle intervention program on cognition in carriers of the APOE ε4 allele.
The use of deep brain stimulation at the VC/VS region is well tolerated for patients with Alzheimer disease.
Spouses who are affected by dementia may benefit from an at-home dyadic, relationship-focused psychoeducational intervention.
These findings support the recognition of alcohol use disorders as a major risk factor for all dementia types.
There are a handful of biomarkers that offer potential value for predicting the risk for development of MCI symptoms from AD symptoms.
The researchers noted that automated tests should not be used alone, but should instead be used as part of a comprehensive evaluation that must include clinical judgment and involve traditional assessor-guided cognitive batteries.
Positive beliefs about age may protect against dementia.
Depressive symptoms and apathy were independently associated with incident dementia in community-dwelling older adults.
Increased triglyceride levels at midlife are predictive of the presence of β-amyloid 20 years later in cognitively healthy individuals.
There is a greater risk for cognitive decline and impairment in elderly patients who experience age-related hearing loss.
In the United States, it is estimated that 15 million people will have clinical Alzheimer disease or mild cognitive impairment by 2060.
Dementia risk was associated with neither proton pump inhibitor exposure nor duration of use.
Low memory scores are not a good tool for measure early Alzheimer's disease in people without dementia.
Low and high serum magnesium levels were shown to be associated with increased risk of all-cause dementia.
Language deficits as well as EEG recordings may be of value for predicting Alzheimer's disease in patients with mild cognitive impairment.
In patients with mild cognitive impairment, CSF and MRI findings are highly predicitve of Alzheimer disease and dementia risk.
More research is needed on the correlation between personality and Alzheimer disease biomarkers.
Intepirdine did not meet efficacy endpoints in a Phase 3 trial for Alzheimer disease.
There is no significant risk of Alzheimer's disease or dementia for men getting androgen deprivation therapy.
Researchers found that patients with a diagnosis of dementia had a significantly different lithium exposure than controls.
There is an increased risk for dementia, especially in black individuals, who are born in a high stroke mortality state.
Depressive symptoms and subjective memory complaint could be used as early detection markers of Alzheimer's disease.
Midlife vascular risk factors such as smoking, diabetes, and hypertension are linked to a higher risk for dementia.
People born in higher stroke mortality states seem to have more health issues including a higher risk of developing dementia.
Obstructive sleep apnea and sleep-disordered breathing are associated with amyloid deposition, biomarkers for Alzheimer's disease.
Risk for dementia is not increased by the use of PPIs.
Lower risk of mortality is linked with increased childhood intelligence's.
With special training and medication, Alzheimer's patients can relearn some basic skills.
It may be possible to grow old without developing Alzheimer's disease pathology.
Performance was consistently better in those who reported engaging in puzzles, and generally improved incrementally with the frequency of puzzle use.
More research is needed to assess the effect of modifying sleep on the brain.
Dementia may not be preventable by weight loss interventions focused on increased physical activity and portion control.
Three promising areas of future research in cognitive decline are blood pressure, cognitive training, and physical exercise.
Dual task gait training is predictive of clinical progression of mild cognitive impairment leading to dementia.
Older adults with constant pain showed an increase in rapid memory loss and greater probability of dementia than older adults without constant pain.
The mortality rate from Alzheimer's increased 54.5 percent — from 16.5 per 100,000 people in 1999 to 25.4 per 100,000 in 2014.
Neuropsychiatric symptoms, specifically sleep behavior and irritability, may be an early symptom of Alzheimer's dementia.
Serum IL-6 levels may serve as biomarkers for Alzheimer's disease.
Alzheimer's disease risk increases for hospitalized patients with shorter than a 5-year window.
A history of 2 or more vascular risk factors was associated with a significantly higher rate of amyloid deposits on PET scans at last visit.
Early occult hippocampal hyperexcitability may contribute to the pathogenesis of Alzheimer's disease.
More than 81% of participants reported adverse events, but rates were similar between groups.
Psychosis in AD is associated with the female-specific APOE4 gene and is comorbid with Lewy bodies.
Alzheimer disease treatment with benzodiazepine includes a possibly greater risk of penumonia.
A higher risk of dementia might be tied to prostate cancer treatment.
People with a history of autoimmune disease-related hospital admission are more likely to develop dementia.
Having heart disease risks in middle age may increase the risk for developing dementia later in life.
Cardiovascular disease may serve as a good biomarker of potential risk for Alzheimer's dementia.
A 5-year study found that people who exercised regularly had a significantly reduced risk of dementia diagnosis.
As stroke is often detrimental for individuals with AD, these results warrant caution in BZDR use in this vulnerable population.
Middle-aged men who frequent saunas are less likely to develop dementia.
The ASCOMALVA trial sought to decrease the frequency and severity of behavioral and psychological symptoms of dementia.
Dexmedetomidine reduced postoperative delirium by 14% in elderly patients following cardiac surgery.
Cardiovascular disease, stroke, diabetes, hip and knee replacements, and both behavioral and mental disorders were also more common in the AD cohort.
People who live relatively close to busy traffic have a slightly higher risk for dementia
Normal cognitive function is associated with a more stable weight trajectory in older women.
Continuing warfarin after a diagnosis of dementia is associated with a protective effect in prevention of stroke and mortality.
Researchers found that valproic acid increased the risk of Alzheimer's disease.
Cerebral microbleeds connected to cognitive impairment and stroke may be tied to Streptococcus mutans.
The reduction in risk of Alzheimer disease was varied across sex, race, ethnicity, and type of statin used.
A Goals of Care video aid informs family members of patients with advanced dementia about treatment choices.
Hormone therapy may reduce risk for death from vascular dementia in older women.
The risk of developing pneumonia is higher among patients who use antidementia drugs.
In a large Taiwanese cohort, the overall rate of dementia was higher in the group with disease than in controls.
Rates of potentially unsafe medication are higher among veterans with dementia using VA-Medicare Part D system.
Amyloid deposits can lead to compromised myocardial function.
Researchers found that higher amyloid-β protein levels in saliva were significantly associated with Alzheimer's patients.
Eli Lilly's investigational Alzheimer's drug did not meet the primary end point in the phase 3 EXPEDITION3 trial.
These findings, combined with those from prior observational research, provide a solid rationale for further randomized trials.
A Cochrane systematic review found a clear lack of evidence for pharmacologic guidance of sleep problems in dementia.
Someone whose hippocampus stayed the same size was nearly 6 times more likely to develop Lewy body dementia.
Recognition of self-reported symptoms that may appear at early onset of amyloid accumulation, such as loneliness, point to opportunities for preventive therapies.
The longer the duration of ADT, the greater the risk of dementia.
One hypothesis is that thyroid function affects dementia risk through nonvascular pathways.
Most research to date has focused on the association between depression and dementia, but not many studies were performed to investigate the link between anxiety and dementia.
Those with lower BMI showed higher levels of beta-amyloid, closely tied to the onset of Alzheimer's disease.
Analysis of over 1.4 million Medicare beneficiaries found that fragmented care led to an additional $567 million to $1.1 billion in health care spending.
The findings suggest that interactions between beta-amyloid and tau lead to neurodegeneration in Alzheimer's.
The effects of aggregate genetic AD risk are detectable before symptoms appear, even early in life.
If transmission of neurodegenerative diseases such as dementia of any type, AD, or PD does occur, it is rare.
Tetrahydrocannabinol (THC) is the main active chemical ingredient found in cannabis and is a potent cannabinoid receptor (CB)-1 agonist.
Modifiable risk factors (eg, smoking, hypertension, sedentary behavior, overweight/obesity, and social engagement) contribute to nearly half of documented dementia cases.
Cognitive test scores are negatively correlated with blood-brain barrier disruption in patients with early AD.
Patients with atrial fibrillation who have been treated with warfarin may have an increased risk of developing dementia.
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