Alzheimer’s Disease and Dementia Archive

Traumatic Brain Injury Associated With Increased Risk for Dementia

Traumatic Brain Injury Associated With Increased Risk for Dementia

These data support the importance of TBI preventative measures and proper management strategies for subsequent dementia.

Association Between Psychosis and Development of Dementia in Older Men

Association Between Psychosis and Development of Dementia in Older Men

The findings also suggested that more a more recent diagnosis of psychosis was a greater predictor of the development of dementia, as opposed to cases where patients had been living with psychotic disorder diagnoses for 10 years or more.

Phonemic Verbal Advantage in Mild Cognitive Impairment May Predict Risk for Alzheimer Disease

Phonemic Verbal Advantage in Mild Cognitive Impairment May Predict Risk for Alzheimer Disease

Patients with a phonemic advantage at baseline should be followed more closely with a higher index of suspicion for progression to Alzheimer disease.

Dementia Care: Prescribing Trends of Antipsychotics, Mood Stabilizers, and Psychotropic Medications

Dementia Care: Prescribing Trends of Antipsychotics, Mood Stabilizers, and Psychotropic Medications

Researchers concluded that the partnership did not accelerate the overall decline in antipsychotic medication use among study participants.

Assessing Parental Symptom Onset Proximity in Alzheimer Disease

Assessing Parental Symptom Onset Proximity in Alzheimer Disease

Investigators evaluated CSF Aβ1-42 levels obtained from individuals who presented no signs of cognitive dysfunction at enrollment and estimated the proximity of participants' age to their parents' age of AD symptom onset.

Healthy Lifestyle May Protect Against Dementia in Older Adult Carriers of APOE ε4

Healthy Lifestyle May Protect Against Dementia in Older Adult Carriers of APOE ε4

A study was conducted to assess potential beneficial effects of a lifestyle intervention program on cognition in carriers of the APOE ε4 allele.

Safety, Efficacy of Deep Brain Stimulation for Alzheimer Disease Examined

Safety, Efficacy of Deep Brain Stimulation for Alzheimer Disease Examined

The use of deep brain stimulation at the VC/VS region is well tolerated for patients with Alzheimer disease.

At-Home Program Aids Communication for Spouses With Dementia

At-Home Program Aids Communication for Spouses With Dementia

Spouses who are affected by dementia may benefit from an at-home dyadic, relationship-focused psychoeducational intervention.

Alcohol Use Disorder a Major Risk Factor in Dementia Onset

Alcohol Use Disorder a Major Risk Factor in Dementia Onset

These findings support the recognition of alcohol use disorders as a major risk factor for all dementia types.

Predicting Progression From Normal Cognition to Mild Cognitive Impairment

Predicting Progression From Normal Cognition to Mild Cognitive Impairment

There are a handful of biomarkers that offer potential value for predicting the risk for development of MCI symptoms from AD symptoms.

Systematic Review of Automated Cognitive Tests Yields Little Useful Clinical Guidance

Systematic Review of Automated Cognitive Tests Yields Little Useful Clinical Guidance

The researchers noted that automated tests should not be used alone, but should instead be used as part of a comprehensive evaluation that must include clinical judgment and involve traditional assessor-guided cognitive batteries.

Positive Beliefs About Age May Protect Older Adults Against Dementia

Positive Beliefs About Age May Protect Older Adults Against Dementia

Positive beliefs about age may protect against dementia.

Symptoms of Apathy Linked With Risk for Dementia in Older Adults

Symptoms of Apathy Linked With Risk for Dementia in Older Adults

Depressive symptoms and apathy were independently associated with incident dementia in community-dwelling older adults.

Increased Midlife Triglyceride Levels May Be a Modifiable Risk Factor for Alzheimer Disease

Increased Midlife Triglyceride Levels May Be a Modifiable Risk Factor for Alzheimer Disease

Increased triglyceride levels at midlife are predictive of the presence of β-amyloid 20 years later in cognitively healthy individuals.

Risk for Dementia, Cognitive Decline May Be Linked to Age-Related Hearing Loss

Risk for Dementia, Cognitive Decline May Be Linked to Age-Related Hearing Loss

There is a greater risk for cognitive decline and impairment in elderly patients who experience age-related hearing loss.

Predicted Prevalence of Alzheimer Disease in the United States by 2060

Predicted Prevalence of Alzheimer Disease in the United States by 2060

In the United States, it is estimated that 15 million people will have clinical Alzheimer disease or mild cognitive impairment by 2060.

Dementia Risk Not Associated With Proton Pump Inhibitor Use

Dementia Risk Not Associated With Proton Pump Inhibitor Use

Dementia risk was associated with neither proton pump inhibitor exposure nor duration of use.

Memory Scores Have Limited Value as Early Alzheimer Disease Screening Tools

Memory Scores Have Limited Value as Early Alzheimer Disease Screening Tools

Low memory scores are not a good tool for measure early Alzheimer's disease in people without dementia.

Nonoptimal Serum Magnesium Levels Associated With Incident Dementia

Nonoptimal Serum Magnesium Levels Associated With Incident Dementia

Low and high serum magnesium levels were shown to be associated with increased risk of all-cause dementia.

Alzheimer Disease Progression in Patients With MCI Predicted by EEG, Language Deficits

Alzheimer Disease Progression in Patients With MCI Predicted by EEG, Language Deficits

Language deficits as well as EEG recordings may be of value for predicting Alzheimer's disease in patients with mild cognitive impairment.

Abnormal MRI and CSF Findings May Predict Risk for Alzheimer Disease

Abnormal MRI and CSF Findings May Predict Risk for Alzheimer Disease

In patients with mild cognitive impairment, CSF and MRI findings are highly predicitve of Alzheimer disease and dementia risk.

No Evidence of Personality Changes Prior to Developing Cognitive Impairment, Dementia

No Evidence of Personality Changes Prior to Developing Cognitive Impairment, Dementia

More research is needed on the correlation between personality and Alzheimer disease biomarkers.

Intepirdine Does Not Demonstrate Significant Improvement for Alzheimer Disease

Intepirdine Does Not Demonstrate Significant Improvement for Alzheimer Disease

Intepirdine did not meet efficacy endpoints in a Phase 3 trial for Alzheimer disease.

Alzheimer Disease Risk Not Increased With Androgen Deprivation Therapy

Alzheimer Disease Risk Not Increased With Androgen Deprivation Therapy

There is no significant risk of Alzheimer's disease or dementia for men getting androgen deprivation therapy.

Lower Levels of Dementia Associated With Lithium in Drinking Water

Lower Levels of Dementia Associated With Lithium in Drinking Water

Researchers found that patients with a diagnosis of dementia had a significantly different lithium exposure than controls.

Risk of Dementia Later in Life Linked to Stroke Mortality Rate At Birth

Risk of Dementia Later in Life Linked to Stroke Mortality Rate At Birth

There is an increased risk for dementia, especially in black individuals, who are born in a high stroke mortality state.

Early Detection Markers of Alzheimer's Disease Possibly Identified

Early Detection Markers of Alzheimer's Disease Possibly Identified

Depressive symptoms and subjective memory complaint could be used as early detection markers of Alzheimer's disease.

Higher Risk of Dementia Associated With Midlife Vascular Risk Factors

Higher Risk of Dementia Associated With Midlife Vascular Risk Factors

Midlife vascular risk factors such as smoking, diabetes, and hypertension are linked to a higher risk for dementia.

Risk of Dementia Higher in Those Hailing From 'Stroke Belt'

Risk of Dementia Higher in Those Hailing From 'Stroke Belt'

People born in higher stroke mortality states seem to have more health issues including a higher risk of developing dementia.

Alzheimer's Disease Linked to OSA, Sleep-disordered Breathing

Alzheimer's Disease Linked to OSA, Sleep-disordered Breathing

Obstructive sleep apnea and sleep-disordered breathing are associated with amyloid deposition, biomarkers for Alzheimer's disease.

Dementia Not Associated With Use of Proton-pump Inhibitors

Dementia Not Associated With Use of Proton-pump Inhibitors

Risk for dementia is not increased by the use of PPIs.

Childhood Intelligence Inversely Associated With All Major Causes of Mortality

Childhood Intelligence Inversely Associated With All Major Causes of Mortality

Lower risk of mortality is linked with increased childhood intelligence's.

Alzheimer's Disease Skill Loss Reversed With Memory Coaching, Support

Alzheimer's Disease Skill Loss Reversed With Memory Coaching, Support

With special training and medication, Alzheimer's patients can relearn some basic skills.

Aging Without Alzheimer's Pathology Is Achievable

Aging Without Alzheimer's Pathology Is Achievable

It may be possible to grow old without developing Alzheimer's disease pathology.

Crossword Puzzles Benefit Cognitive Performance, Memory

Crossword Puzzles Benefit Cognitive Performance, Memory

Performance was consistently better in those who reported engaging in puzzles, and generally improved incrementally with the frequency of puzzle use.

Sleep Quality May Impact Alzheimer's Disease Pathology

Sleep Quality May Impact Alzheimer's Disease Pathology

More research is needed to assess the effect of modifying sleep on the brain.

Dementia May Not Be Benefited By Weight Loss Interventions

Dementia May Not Be Benefited By Weight Loss Interventions

Dementia may not be preventable by weight loss interventions focused on increased physical activity and portion control.

Cognitive Decline Delayed By Three Lifestyle Changes

Cognitive Decline Delayed By Three Lifestyle Changes

Three promising areas of future research in cognitive decline are blood pressure, cognitive training, and physical exercise.

Mild Cognitive Impairment Predicted By Dual Gait Task Training

Mild Cognitive Impairment Predicted By Dual Gait Task Training

Dual task gait training is predictive of clinical progression of mild cognitive impairment leading to dementia.

Greater Dementia Probability For Adults With Persistent Pain

Greater Dementia Probability For Adults With Persistent Pain

Older adults with constant pain showed an increase in rapid memory loss and greater probability of dementia than older adults without constant pain.

Alzheimer's Disease Mortality Rate Has Increased 55 Percent

Alzheimer's Disease Mortality Rate Has Increased 55 Percent

The mortality rate from Alzheimer's increased 54.5 percent — from 16.5 per 100,000 people in 1999 to 25.4 per 100,000 in 2014.

Sleep Behavior, Irritability May Be an Early Symptom of Alzheimer's Disease

Sleep Behavior, Irritability May Be an Early Symptom of Alzheimer's Disease

Neuropsychiatric symptoms, specifically sleep behavior and irritability, may be an early symptom of Alzheimer's dementia.

Serum Levels of Il-6 May Correlate With Cognitive Impairment in AD

Serum Levels of Il-6 May Correlate With Cognitive Impairment in AD

Serum IL-6 levels may serve as biomarkers for Alzheimer's disease.

Increased Alzheimer's Disease Risk in Hospital-Treated Patients

Increased Alzheimer's Disease Risk in Hospital-Treated Patients

Alzheimer's disease risk increases for hospitalized patients with shorter than a 5-year window.

Alzheimer's Disease More Associated With Vascular Risk Factors in Mid-Life Than Later Life

Alzheimer's Disease More Associated With Vascular Risk Factors in Mid-Life Than Later Life

A history of 2 or more vascular risk factors was associated with a significantly higher rate of amyloid deposits on PET scans at last visit.

Silent Seizures May Affect Alzheimer's Pathology

Silent Seizures May Affect Alzheimer's Pathology

Early occult hippocampal hyperexcitability may contribute to the pathogenesis of Alzheimer's disease.

Many Patients With Alzheimer's Discontinue AChEIs

Many Patients With Alzheimer's Discontinue AChEIs

More than 81% of participants reported adverse events, but rates were similar between groups.

Psychosis in Alzheimer's Disease Induced by Female-Specific Gene

Psychosis in Alzheimer's Disease Induced by Female-Specific Gene

Psychosis in AD is associated with the female-specific APOE4 gene and is comorbid with Lewy bodies.

Alzheimer Disease Patients on Benzodiazepine Have Greater Risk for Pneumonia

Alzheimer Disease Patients on Benzodiazepine Have Greater Risk for Pneumonia

Alzheimer disease treatment with benzodiazepine includes a possibly greater risk of penumonia.

Dementia Risk Possibly Increased by Prostate Cancer Therapy

Dementia Risk Possibly Increased by Prostate Cancer Therapy

A higher risk of dementia might be tied to prostate cancer treatment.

Dementia Risk Tied to Autoimmune Disease Hospitalization

Dementia Risk Tied to Autoimmune Disease Hospitalization

People with a history of autoimmune disease-related hospital admission are more likely to develop dementia.

Dementia Risk Increased With Middle Age Heart Disease

Dementia Risk Increased With Middle Age Heart Disease

Having heart disease risks in middle age may increase the risk for developing dementia later in life.

Mild Alzheimer's Disease: AFib, Heart Failure as Promising Targets

Mild Alzheimer's Disease: AFib, Heart Failure as Promising Targets

Cardiovascular disease may serve as a good biomarker of potential risk for Alzheimer's dementia.

Exercise Vital to Dementia Prevention

Exercise Vital to Dementia Prevention

A 5-year study found that people who exercised regularly had a significantly reduced risk of dementia diagnosis.

Benzodiazepines Increase Stroke Risk in Alzheimer's

Benzodiazepines Increase Stroke Risk in Alzheimer's

As stroke is often detrimental for individuals with AD, these results warrant caution in BZDR use in this vulnerable population.

Sauna Use Lessens Likelihood of Dementia Diagnosis

Middle-aged men who frequent saunas are less likely to develop dementia.

Combination Tx Reduces Behavioral Disturbances in Alzheimer's Disease

Combination Tx Reduces Behavioral Disturbances in Alzheimer's Disease

The ASCOMALVA trial sought to decrease the frequency and severity of behavioral and psychological symptoms of dementia.

Low-Dose Dexmedetomidine Reduces Postoperative Delirium in Older Patients

Low-Dose Dexmedetomidine Reduces Postoperative Delirium in Older Patients

Dexmedetomidine reduced postoperative delirium by 14% in elderly patients following cardiac surgery.

Alzheimer's Disease is a Significant Risk Factor for Major Hip Fracture

Alzheimer's Disease is a Significant Risk Factor for Major Hip Fracture

Cardiovascular disease, stroke, diabetes, hip and knee replacements, and both behavioral and mental disorders were also more common in the AD cohort.

Higher Risk for Dementia in Those Living Near Major Roadways

Higher Risk for Dementia in Those Living Near Major Roadways

People who live relatively close to busy traffic have a slightly higher risk for dementia

Greater Weight Loss in Old Age Linked With MCI, Dementia

Greater Weight Loss in Old Age Linked With MCI, Dementia

Normal cognitive function is associated with a more stable weight trajectory in older women.

Veterans with Dementia on Warfarin Protected Against Stroke, Mortality

Veterans with Dementia on Warfarin Protected Against Stroke, Mortality

Continuing warfarin after a diagnosis of dementia is associated with a protective effect in prevention of stroke and mortality.

Does Lithium Use Decrease Alzheimer's Risk?

Does Lithium Use Decrease Alzheimer's Risk?

Researchers found that valproic acid increased the risk of Alzheimer's disease.

Cognitive Impairment Linked to Collagen-Binding Activity

Cognitive Impairment Linked to Collagen-Binding Activity

Cerebral microbleeds connected to cognitive impairment and stroke may be tied to Streptococcus mutans.

High Statin Use May Reduce Risk of Alzheimer's Disease

High Statin Use May Reduce Risk of Alzheimer's Disease

The reduction in risk of Alzheimer disease was varied across sex, race, ethnicity, and type of statin used.

New Decision-Aid Intervention Improves Care in Advanced Dementia

New Decision-Aid Intervention Improves Care in Advanced Dementia

A Goals of Care video aid informs family members of patients with advanced dementia about treatment choices.

Hormone Therapy May Reduce Mortality Risk From Vascular Dementia

Hormone Therapy May Reduce Mortality Risk From Vascular Dementia

Hormone therapy may reduce risk for death from vascular dementia in older women.

Link Between Antidementia Drug Use and Pneumonia Examined

Link Between Antidementia Drug Use and Pneumonia Examined

The risk of developing pneumonia is higher among patients who use antidementia drugs.

Colonic Diverticular Disease May Increase Risk of Dementia

Colonic Diverticular Disease May Increase Risk of Dementia

In a large Taiwanese cohort, the overall rate of dementia was higher in the group with disease than in controls.

Increased Unsafe Med Scripts for Dual-System Users With Dementia

Increased Unsafe Med Scripts for Dual-System Users With Dementia

Rates of potentially unsafe medication are higher among veterans with dementia using VA-Medicare Part D system.

Amyloid Beta Deposits Can Affect The Heart in Alzheimer's

Amyloid Beta Deposits Can Affect The Heart in Alzheimer's

Amyloid deposits can lead to compromised myocardial function.

Saliva Test To Help Predict Alzheimer's Disease

Saliva Test To Help Predict Alzheimer's Disease

Researchers found that higher amyloid-β protein levels in saliva were significantly associated with Alzheimer's patients.

Alzheimer's Trial: Solanezumab Fails Primary End Point

Alzheimer's Trial: Solanezumab Fails Primary End Point

Eli Lilly's investigational Alzheimer's drug did not meet the primary end point in the phase 3 EXPEDITION3 trial.

New Data Shows Causal Link Between Vitamin D, Alzheimer's Risk

New Data Shows Causal Link Between Vitamin D, Alzheimer's Risk

These findings, combined with those from prior observational research, provide a solid rationale for further randomized trials.

Drug Therapy Guidance Lacking for Sleep Disorders in Dementia

Drug Therapy Guidance Lacking for Sleep Disorders in Dementia

A Cochrane systematic review found a clear lack of evidence for pharmacologic guidance of sleep problems in dementia.

MRI May Help Identify Lewy Body Dementia vs Alzheimer's

MRI May Help Identify Lewy Body Dementia vs Alzheimer's

Someone whose hippocampus stayed the same size was nearly 6 times more likely to develop Lewy body dementia.

Loneliness May Be a Precursor to Alzheimer's Disease

Loneliness May Be a Precursor to Alzheimer's Disease

Recognition of self-reported symptoms that may appear at early onset of amyloid accumulation, such as loneliness, point to opportunities for preventive therapies.

Probability of Dementia Higher in Men Receiving Androgen Deprivation Therapy

Probability of Dementia Higher in Men Receiving Androgen Deprivation Therapy

The longer the duration of ADT, the greater the risk of dementia.

High Thyroid Hormone Levels May Increase Dementia Risk

High Thyroid Hormone Levels May Increase Dementia Risk

One hypothesis is that thyroid function affects dementia risk through nonvascular pathways.

Anxiety is a Risk Factor for Cognitive Decline and Dementia

Anxiety is a Risk Factor for Cognitive Decline and Dementia

Most research to date has focused on the association between depression and dementia, but not many studies were performed to investigate the link between anxiety and dementia.

How Does BMI Affect Alzheimer's Risk?

How Does BMI Affect Alzheimer's Risk?

Those with lower BMI showed higher levels of beta-amyloid, closely tied to the onset of Alzheimer's disease.

How Continuity of Care Affects Hospitalizations, Health Care Costs in Dementia

How Continuity of Care Affects Hospitalizations, Health Care Costs in Dementia

Analysis of over 1.4 million Medicare beneficiaries found that fragmented care led to an additional $567 million to $1.1 billion in health care spending.

PET Imaging Can Assist In Identifying Alzheimer's Disease Stage

PET Imaging Can Assist In Identifying Alzheimer's Disease Stage

The findings suggest that interactions between beta-amyloid and tau lead to neurodegeneration in Alzheimer's.

Alzheimer Markers Detected in Healthy Individuals with Genetic AD Risk

Alzheimer Markers Detected in Healthy Individuals with Genetic AD Risk

The effects of aggregate genetic AD risk are detectable before symptoms appear, even early in life.

No Evidence for Transmission of Alzheimer Pathology Through Blood Transfusions

No Evidence for Transmission of Alzheimer Pathology Through Blood Transfusions

If transmission of neurodegenerative diseases such as dementia of any type, AD, or PD does occur, it is rare.

Cannabinoids Reduce Intraneuronal Beta Amyloid Protein Levels

Cannabinoids Reduce Intraneuronal Beta Amyloid Protein Levels

Tetrahydrocannabinol (THC) is the main active chemical ingredient found in cannabis and is a potent cannabinoid receptor (CB)-1 agonist.

Physical Activity During Midlife Influences Late Life Verbal Memory Performance

Physical Activity During Midlife Influences Late Life Verbal Memory Performance

Modifiable risk factors (eg, smoking, hypertension, sedentary behavior, overweight/obesity, and social engagement) contribute to nearly half of documented dementia cases.

Leaky Blood-Brain Barrier Associated With Cognitive Decline in Early Alzheimer Disease

Leaky Blood-Brain Barrier Associated With Cognitive Decline in Early Alzheimer Disease

Cognitive test scores are negatively correlated with blood-brain barrier disruption in patients with early AD.

Atrial Fibrillation, Warfarin Use May Increase Dementia Risk

Atrial Fibrillation, Warfarin Use May Increase Dementia Risk

Patients with atrial fibrillation who have been treated with warfarin may have an increased risk of developing dementia.

Novel Case: Alzheimer's Reported in HIV+ Patient

Novel Case: Alzheimer's Reported in HIV+ Patient

The case suggests that some patients with HIV and dementia may be misdiagnosed with HIV-associated brain disorders.

Improved Cognitive Assessment Test to Screen for Dementia

Improved Cognitive Assessment Test to Screen for Dementia

Administration time for cognitive assessment screenings is currently suboptimal in many clinical settings.

Sensory Stimulation May Benefit Patients with Dementia

Sensory Stimulation May Benefit Patients with Dementia

Researchers identified 8 categories of sensory stimulation interventions that significantly influenced dementia.

White Matter Hyperintensities Predate Onset of Alzheimer's

White Matter Hyperintensities Predate Onset of Alzheimer's

White matter hyperintensity volume differences were seen 6 years before Alzheimer's symptoms.

Scientists Discover How Tau Affects Memory Loss In Dementia

Scientists Discover How Tau Affects Memory Loss In Dementia

While scientists have long known that tau is involved in dementia, the way in which it hinders cognitive function has remained uncertain.

Dementia Risk Greater When Depression Symptoms Increase Over Time

Dementia Risk Greater When Depression Symptoms Increase Over Time

Whether depression is a risk factor for dementia or a symptom of an underlying neurodegenerative process is a complex question.

Can Herpes Cause Alzheimer's Disease?

Can Herpes Cause Alzheimer's Disease?

A handful of studies indicate that older people with active herpes virus may be more likely to develop Alzheimer's

Higher Rates of Antidepressant Use Associated With Alzheimer's

Higher Rates of Antidepressant Use Associated With Alzheimer's

Patients with Alzheimer's disease received antidepressant prescriptions twice as often as age- and sex-matched peers.

Blueberries May Help Prevent Effects of Alzheimer's

Blueberries May Help Prevent Effects of Alzheimer's

There was improvement in cognitive performance and brain function in those who took the blueberry powder.

Gum Disease May Increase Cognitive Decline Risk in Alzheimer's

Gum Disease May Increase Cognitive Decline Risk in Alzheimer's

Those with the gum disease saw a 6-fold increase in cognitive decline over follow-up.

Immune System May Play Greater Role in Alzheimer's Than Thought

Immune System May Play Greater Role in Alzheimer's Than Thought

While many studies have explored the role of microglia in Alzheimer's, very few researchers have examined the role of the adaptive immune system.

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