Alzheimer’s Disease & Dementia

Trials for Investigational Alzheimer Treatment Lanabecestat Discontinued

Trials for Investigational Alzheimer Treatment Lanabecestat Discontinued

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Phase 3 clinical trials for lanabecestat (Eli Lilly and AstraZeneca), an investigational Alzheimer disease treatment, are being discontinued for futility.

Lifetime Risks Temper Biomarker Tests for Alzheimer Disease Dementia

Lifetime Risks Temper Biomarker Tests for Alzheimer Disease Dementia

The lifetime risks of Alzheimer disease dementia vary considerably by age, gender, and the preclinical or clinical disease state.

Intellectual Activities in Later Life May Cut Dementia Risk

Intellectual Activities in Later Life May Cut Dementia Risk

There is a reduced risk for dementia for older Chinese adults actively participating in intellectual activities.

Greater Wealth Associated With Lower Risk for Dementia in English Study

Greater Wealth Associated With Lower Risk for Dementia in English Study

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Public health strategies for preventing dementia should target socioeconomic gaps to reduce health disparities and protect the disadvantaged.

Anxiety: Feature of Late-Onset Dementia or Modifiable Risk Factor?

Anxiety: Feature of Late-Onset Dementia or Modifiable Risk Factor?

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The researchers encouraged clinicians not to rely solely on medication to treat midlife anxiety, as benzodiazepines have been shown to increase mortality in certain groups; they pointed to talk therapy, meditation, and mindfulness-based interventions as possible considerations.

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

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Multimarker inflammatory biosignatures are expected to facilitate diagnosis and predict treatment outcomes for various central nervous system disorders, particularly Alzheimer disease and major depressive disorder.

Depression in Patients With Dementia May Increase Risk for Heart Disease

Depression in Patients With Dementia May Increase Risk for Heart Disease

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Clinicians should take depression into careful consideration when treating patients with Alzheimer dementia, as the two conditions combined may predispose patients to cardiovascular disease more than either condition alone.

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

These findings indicate that anxiety may be a risk factor for late-life dementia, excluding anxiety that is related to prodromal cognitive decline.

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

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These results suggest that antipsychotic exposure has no impact on relative mortality.

Traumatic Brain Injury Associated With Increased Risk for Dementia

Traumatic Brain Injury Associated With Increased Risk for Dementia

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These data support the importance of TBI preventative measures and proper management strategies for subsequent dementia.

Association Between Psychosis and Development of Dementia in Older Men

Association Between Psychosis and Development of Dementia in Older Men

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The findings also suggested that more a more recent diagnosis of psychosis was a greater predictor of the development of dementia, as opposed to cases where patients had been living with psychotic disorder diagnoses for 10 years or more.

Phonemic Verbal Advantage in Mild Cognitive Impairment May Predict Risk for Alzheimer Disease

Phonemic Verbal Advantage in Mild Cognitive Impairment May Predict Risk for Alzheimer Disease

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Patients with a phonemic advantage at baseline should be followed more closely with a higher index of suspicion for progression to Alzheimer disease.

Assessing Parental Symptom Onset Proximity in Alzheimer Disease

Assessing Parental Symptom Onset Proximity in Alzheimer Disease

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Investigators evaluated CSF Aβ1-42 levels obtained from individuals who presented no signs of cognitive dysfunction at enrollment and estimated the proximity of participants' age to their parents' age of AD symptom onset.

At-Home Program Aids Communication for Spouses With Dementia

At-Home Program Aids Communication for Spouses With Dementia

Spouses who are affected by dementia may benefit from an at-home dyadic, relationship-focused psychoeducational intervention.

Alcohol Use Disorder a Major Risk Factor in Dementia Onset

Alcohol Use Disorder a Major Risk Factor in Dementia Onset

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These findings support the recognition of alcohol use disorders as a major risk factor for all dementia types.

Predicting Progression From Normal Cognition to Mild Cognitive Impairment

Predicting Progression From Normal Cognition to Mild Cognitive Impairment

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There are a handful of biomarkers that offer potential value for predicting the risk for development of MCI symptoms from AD symptoms.

Systematic Review of Automated Cognitive Tests Yields Little Useful Clinical Guidance

Systematic Review of Automated Cognitive Tests Yields Little Useful Clinical Guidance

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The researchers noted that automated tests should not be used alone, but should instead be used as part of a comprehensive evaluation that must include clinical judgment and involve traditional assessor-guided cognitive batteries.

Dementia Risk Not Associated With Proton Pump Inhibitor Use

Dementia Risk Not Associated With Proton Pump Inhibitor Use

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Dementia risk was associated with neither proton pump inhibitor exposure nor duration of use.

Memory Scores Have Limited Value as Early Alzheimer Disease Screening Tools

Memory Scores Have Limited Value as Early Alzheimer Disease Screening Tools

Low memory scores are not a good tool for measure early Alzheimer's disease in people without dementia.

Protecting the Brain:  The Damaging Impact of Traumatic Brain Injury

Protecting the Brain: The Damaging Impact of Traumatic Brain Injury

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Traumatic brain injury is a significant burden on the US health system and is a contributing factor in one-third of all injury-related deaths.

Alzheimer's Disease Linked to OSA, Sleep-disordered Breathing

Alzheimer's Disease Linked to OSA, Sleep-disordered Breathing

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Obstructive sleep apnea and sleep-disordered breathing are associated with amyloid deposition, biomarkers for Alzheimer's disease.

Aging Without Alzheimer's Pathology Is Achievable

Aging Without Alzheimer's Pathology Is Achievable

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It may be possible to grow old without developing Alzheimer's disease pathology.

Sleep Quality May Impact Alzheimer's Disease Pathology

Sleep Quality May Impact Alzheimer's Disease Pathology

More research is needed to assess the effect of modifying sleep on the brain.

Cognitive Decline Delayed By Three Lifestyle Changes

Cognitive Decline Delayed By Three Lifestyle Changes

Three promising areas of future research in cognitive decline are blood pressure, cognitive training, and physical exercise.

Mild Cognitive Impairment Predicted By Dual Gait Task Training

Mild Cognitive Impairment Predicted By Dual Gait Task Training

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Dual task gait training is predictive of clinical progression of mild cognitive impairment leading to dementia.

Is Depression A Risk Factor Or a Prodromal Symptom of Dementia?

Is Depression A Risk Factor Or a Prodromal Symptom of Dementia?

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Depressive symptoms likely do not increase the risk of dementia.

Sleep Behavior, Irritability May Be an Early Symptom of Alzheimer's Disease

Sleep Behavior, Irritability May Be an Early Symptom of Alzheimer's Disease

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Neuropsychiatric symptoms, specifically sleep behavior and irritability, may be an early symptom of Alzheimer's dementia.

Serum Levels of Il-6 May Correlate With Cognitive Impairment in AD

Serum Levels of Il-6 May Correlate With Cognitive Impairment in AD

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Serum IL-6 levels may serve as biomarkers for Alzheimer's disease.

Increased Alzheimer's Disease Risk in Hospital-Treated Patients

Increased Alzheimer's Disease Risk in Hospital-Treated Patients

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Alzheimer's disease risk increases for hospitalized patients with shorter than a 5-year window.

Alzheimer's Disease More Associated With Vascular Risk Factors in Mid-Life Than Later Life

Alzheimer's Disease More Associated With Vascular Risk Factors in Mid-Life Than Later Life

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A history of 2 or more vascular risk factors was associated with a significantly higher rate of amyloid deposits on PET scans at last visit.

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