Alzheimer’s Disease & Dementia

Amyloid Beta Deposits Can Affect The Heart in Alzheimer's

Amyloid Beta Deposits Can Affect The Heart in Alzheimer's

Amyloid deposits can lead to compromised myocardial function.

Saliva Test To Help Predict Alzheimer's Disease

Saliva Test To Help Predict Alzheimer's Disease

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Researchers found that higher amyloid-β protein levels in saliva were significantly associated with Alzheimer's patients.

Alzheimer's Trial: Solanezumab Fails Primary End Point

Alzheimer's Trial: Solanezumab Fails Primary End Point

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Eli Lilly's investigational Alzheimer's drug did not meet the primary end point in the phase 3 EXPEDITION3 trial.

New Data Shows Causal Link Between Vitamin D, Alzheimer's Risk

New Data Shows Causal Link Between Vitamin D, Alzheimer's Risk

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These findings, combined with those from prior observational research, provide a solid rationale for further randomized trials.

Drug Therapy Guidance Lacking for Sleep Disorders in Dementia

Drug Therapy Guidance Lacking for Sleep Disorders in Dementia

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A Cochrane systematic review found a clear lack of evidence for pharmacologic guidance of sleep problems in dementia.

MRI May Help Identify Lewy Body Dementia vs Alzheimer's

MRI May Help Identify Lewy Body Dementia vs Alzheimer's

Someone whose hippocampus stayed the same size was nearly 6 times more likely to develop Lewy body dementia.

Loneliness May Be a Precursor to Alzheimer's Disease

Loneliness May Be a Precursor to Alzheimer's Disease

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Recognition of self-reported symptoms that may appear at early onset of amyloid accumulation, such as loneliness, point to opportunities for preventive therapies.

Too Few Seniors Planning End-of-Life Care

Too Few Seniors Planning End-of-Life Care

Findings suggest that efforts to encourage more planning aren't working.

Probability of Dementia Higher in Men Receiving Androgen Deprivation Therapy

Probability of Dementia Higher in Men Receiving Androgen Deprivation Therapy

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The longer the duration of ADT, the greater the risk of dementia.

Midlife Hypertension and Late-life Neurocognitive Status

Midlife Hypertension and Late-life Neurocognitive Status

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The American Heart Association issues a scientific statement on the possible link between chronic arterial hypertension and cognitive impairment.

Gender-dependent Differences in Alzheimer Disease Diagnosis

Gender-dependent Differences in Alzheimer Disease Diagnosis

In 2016, an estimated 5.4 million US adults have Alzheimer disease.

High Thyroid Hormone Levels May Increase Dementia Risk

High Thyroid Hormone Levels May Increase Dementia Risk

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One hypothesis is that thyroid function affects dementia risk through nonvascular pathways.

Sundowning: Phenomenology, Pathophysiology, and Treatment Approaches

Sundowning: Phenomenology, Pathophysiology, and Treatment Approaches

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Sundowning is a complex multifactorial condition that has eluded rigorous understanding of its pathophysiological causes.

Alcohol Consumption and Alzheimer Disease: A Brief Update

Alcohol Consumption and Alzheimer Disease: A Brief Update

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Basic Research Findings for the Practicing Clinician

Late-onset Depression Associated with Elevated Dementia Risk

Late-onset Depression Associated with Elevated Dementia Risk

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Dementia risk was particularly elevated in patients with depression who had higher scores on cognitive tests at baseline.

How Does BMI Affect Alzheimer's Risk?

How Does BMI Affect Alzheimer's Risk?

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Those with lower BMI showed higher levels of beta-amyloid, closely tied to the onset of Alzheimer's disease.

How Continuity of Care Affects Hospitalizations, Health Care Costs in Dementia

How Continuity of Care Affects Hospitalizations, Health Care Costs in Dementia

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Analysis of over 1.4 million Medicare beneficiaries found that fragmented care led to an additional $567 million to $1.1 billion in health care spending.

PET Imaging Can Assist In Identifying Alzheimer's Disease Stage

PET Imaging Can Assist In Identifying Alzheimer's Disease Stage

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The findings suggest that interactions between beta-amyloid and tau lead to neurodegeneration in Alzheimer's.

Deep Brain Stimulation Appears Safe in Alzheimer's

Deep Brain Stimulation Appears Safe in Alzheimer's

Participants aged ≥65 years may have derived benefit from stimulation, while there was possible worsening in patients below age 65 years.

Vascular Intervention Appears Not To Affect Dementia Incidence

Vascular Intervention Appears Not To Affect Dementia Incidence

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Cases of all-cause dementia and Alzheimer's did not significantly differ between study groups, but vascular care is safe and may reduce incidence of non-Alzheimer's dementia.

Alzheimer Markers Detected in Healthy Individuals with Genetic AD Risk

Alzheimer Markers Detected in Healthy Individuals with Genetic AD Risk

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The effects of aggregate genetic AD risk are detectable before symptoms appear, even early in life.

CSF Biomarkers Improve Diagnosis in Patients with Psychiatric Disorders & Cognitive Symptoms

CSF Biomarkers Improve Diagnosis in Patients with Psychiatric Disorders & Cognitive Symptoms

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Distinguishing between psychiatric disorders and AD is crucial because of the differing prognosis and management of the two.

No Evidence for Transmission of Alzheimer Pathology Through Blood Transfusions

No Evidence for Transmission of Alzheimer Pathology Through Blood Transfusions

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If transmission of neurodegenerative diseases such as dementia of any type, AD, or PD does occur, it is rare.

Cannabinoids Reduce Intraneuronal Beta Amyloid Protein Levels

Cannabinoids Reduce Intraneuronal Beta Amyloid Protein Levels

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Tetrahydrocannabinol (THC) is the main active chemical ingredient found in cannabis and is a potent cannabinoid receptor (CB)-1 agonist.

Physical Activity During Midlife Influences Late Life Verbal Memory Performance

Physical Activity During Midlife Influences Late Life Verbal Memory Performance

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Modifiable risk factors (eg, smoking, hypertension, sedentary behavior, overweight/obesity, and social engagement) contribute to nearly half of documented dementia cases.

Leaky Blood-Brain Barrier Associated With Cognitive Decline in Early Alzheimer Disease

Leaky Blood-Brain Barrier Associated With Cognitive Decline in Early Alzheimer Disease

Cognitive test scores are negatively correlated with blood-brain barrier disruption in patients with early AD.

Could Alzheimer's Disease be Caused by Infections?

Could Alzheimer's Disease be Caused by Infections?

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Although inconclusive, late-onset Alzheimer's Disease could be triggered by infectious pathogens.

Atrial Fibrillation, Warfarin Use May Increase Dementia Risk

Atrial Fibrillation, Warfarin Use May Increase Dementia Risk

Patients with atrial fibrillation who have been treated with warfarin may have an increased risk of developing dementia.

Homocysteine Levels Elevated in Alzheimer's Disease

Homocysteine Levels Elevated in Alzheimer's Disease

Researchers identified increased fibrinogen levels and amyloid-β deposits in the blood vessels and brain parenchyma of patients with Alzheimer's disease.

Novel Case: Alzheimer's Reported in HIV+ Patient

Novel Case: Alzheimer's Reported in HIV+ Patient

The case suggests that some patients with HIV and dementia may be misdiagnosed with HIV-associated brain disorders.

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