Alzheimer’s Disease & Dementia
Concussions may be associated with accelerated cortical thickness and memory decline in Alzheimer's disease-relevant areas.
Cardiovascular disease, stroke, diabetes, hip and knee replacements, and both behavioral and mental disorders were also more common in the AD cohort.
Tideglusib, an Alzheimer's disease treatment, stimulates renewal of stem cells in the tooth pulp, enabling natural tooth repair.
Normal cognitive function is associated with a more stable weight trajectory in older women.
Food in a Mediterranean diet protects against loss of brain volume in older populations.
Researchers found that valproic acid increased the risk of Alzheimer's disease.
Hormone therapy may reduce risk for death from vascular dementia in older women.
The risk of developing pneumonia is higher among patients who use antidementia drugs.
In a large Taiwanese cohort, the overall rate of dementia was higher in the group with disease than in controls.
Rates of potentially unsafe medication are higher among veterans with dementia using VA-Medicare Part D system.
Amyloid deposits can lead to compromised myocardial function.
Researchers found that higher amyloid-β protein levels in saliva were significantly associated with Alzheimer's patients.
Eli Lilly's investigational Alzheimer's drug did not meet the primary end point in the phase 3 EXPEDITION3 trial.
These findings, combined with those from prior observational research, provide a solid rationale for further randomized trials.
A Cochrane systematic review found a clear lack of evidence for pharmacologic guidance of sleep problems in dementia.
Someone whose hippocampus stayed the same size was nearly 6 times more likely to develop Lewy body dementia.
Recognition of self-reported symptoms that may appear at early onset of amyloid accumulation, such as loneliness, point to opportunities for preventive therapies.
Findings suggest that efforts to encourage more planning aren't working.
The longer the duration of ADT, the greater the risk of dementia.
The American Heart Association issues a scientific statement on the possible link between chronic arterial hypertension and cognitive impairment.
In 2016, an estimated 5.4 million US adults have Alzheimer disease.
One hypothesis is that thyroid function affects dementia risk through nonvascular pathways.
Sundowning is a complex multifactorial condition that has eluded rigorous understanding of its pathophysiological causes.
Basic Research Findings for the Practicing Clinician
Dementia risk was particularly elevated in patients with depression who had higher scores on cognitive tests at baseline.
Those with lower BMI showed higher levels of beta-amyloid, closely tied to the onset of Alzheimer's disease.
Analysis of over 1.4 million Medicare beneficiaries found that fragmented care led to an additional $567 million to $1.1 billion in health care spending.
The findings suggest that interactions between beta-amyloid and tau lead to neurodegeneration in Alzheimer's.
Participants aged ≥65 years may have derived benefit from stimulation, while there was possible worsening in patients below age 65 years.
Cases of all-cause dementia and Alzheimer's did not significantly differ between study groups, but vascular care is safe and may reduce incidence of non-Alzheimer's dementia.
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