Alzheimer’s Disease & Dementia
Traumatic brain injury is a significant burden on the US health system and is a contributing factor in one-third of all injury-related deaths.
Obstructive sleep apnea and sleep-disordered breathing are associated with amyloid deposition, biomarkers for Alzheimer's disease.
It may be possible to grow old without developing Alzheimer's disease pathology.
More research is needed to assess the effect of modifying sleep on the brain.
Three promising areas of future research in cognitive decline are blood pressure, cognitive training, and physical exercise.
Dual task gait training is predictive of clinical progression of mild cognitive impairment leading to dementia.
Depressive symptoms likely do not increase the risk of dementia.
Neuropsychiatric symptoms, specifically sleep behavior and irritability, may be an early symptom of Alzheimer's dementia.
Serum IL-6 levels may serve as biomarkers for Alzheimer's disease.
Alzheimer's disease risk increases for hospitalized patients with shorter than a 5-year window.
A history of 2 or more vascular risk factors was associated with a significantly higher rate of amyloid deposits on PET scans at last visit.
Early occult hippocampal hyperexcitability may contribute to the pathogenesis of Alzheimer's disease.
Women who use hormone therapy after menopause may not have a lower risk of developing Alzheimer's disease.
As stroke is often detrimental for individuals with AD, these results warrant caution in BZDR use in this vulnerable population.
Middle-aged men who frequent saunas are less likely to develop dementia.
Concussions may be associated with accelerated cortical thickness and memory decline in Alzheimer's disease-relevant areas.
Cardiovascular disease, stroke, diabetes, hip and knee replacements, and both behavioral and mental disorders were also more common in the AD cohort.
Tideglusib, an Alzheimer's disease treatment, stimulates renewal of stem cells in the tooth pulp, enabling natural tooth repair.
Normal cognitive function is associated with a more stable weight trajectory in older women.
Food in a Mediterranean diet protects against loss of brain volume in older populations.
Researchers found that valproic acid increased the risk of Alzheimer's disease.
Hormone therapy may reduce risk for death from vascular dementia in older women.
The risk of developing pneumonia is higher among patients who use antidementia drugs.
In a large Taiwanese cohort, the overall rate of dementia was higher in the group with disease than in controls.
Rates of potentially unsafe medication are higher among veterans with dementia using VA-Medicare Part D system.
Amyloid deposits can lead to compromised myocardial function.
Researchers found that higher amyloid-β protein levels in saliva were significantly associated with Alzheimer's patients.
Eli Lilly's investigational Alzheimer's drug did not meet the primary end point in the phase 3 EXPEDITION3 trial.
These findings, combined with those from prior observational research, provide a solid rationale for further randomized trials.
A Cochrane systematic review found a clear lack of evidence for pharmacologic guidance of sleep problems in dementia.
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