Alzheimer’s Disease & Dementia

Apathy Associated With Increased Risk for Dementia

Apathy Associated With Increased Risk for Dementia

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These findings have high clinical relevance because patients with apathy are likely to withdraw from care.

Sugary Drinks, Other Added Sugars May Up Risk for Alzheimer Disease

Sugary Drinks, Other Added Sugars May Up Risk for Alzheimer Disease

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Drinking sugary beverages has been previously linked to markers of preclinical Alzheimer disease, but the risk associated with consuming added sugars is not established.

Intensive Blood Pressure Control Cuts Combined Mild Cognitive Impairment, Dementia Risk

Intensive Blood Pressure Control Cuts Combined Mild Cognitive Impairment, Dementia Risk

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In the previous SPRINT study, researchers compared an intensive BP reduction strategy (target systolic BP <120 mmHg) vs standard BP reduction strategy (target systolic BP <140 mmHg).

Cannabinoid Shows Promise for Reducing Agitation, Aggression in Alzheimer Disease

Cannabinoid Shows Promise for Reducing Agitation, Aggression in Alzheimer Disease

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Although treatment with nabilone significantly improved agitation, cognition, and nutrition, the authors cautioned that sedation should be closely monitored.

Association Between Alcohol Consumption, Cognitive Function Revealed

Association Between Alcohol Consumption, Cognitive Function Revealed

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Participants were drawn from the Health and Retirement Study, which provided multiple observations, genetic information, and previous alcohol use.

Some Statins May Be Associated With Cognition, Memory Deficits

Some Statins May Be Associated With Cognition, Memory Deficits

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Given the lack of differences seen via the NIS, the authors suggested that subjective questionnaires may not be a trustworthy method to assess possible statin-associated cognitive deficits.

Diclofenac Use Slows Cognitive Decline in Alzheimer Disease

Diclofenac Use Slows Cognitive Decline in Alzheimer Disease

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Results showed that most common NSAIDs, including aspirin, ibuprofen, naproxen, and celecoxib, did not alter cognitive degeneration in patients with mild cognitive impairment or Alzheimer disease.

Effect of ACE Inhibitors on Cognition in Alzheimer Disease Dementia

Effect of ACE Inhibitors on Cognition in Alzheimer Disease Dementia

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The genetically-mediated effects of angiotensin-converting enzyme (ACE) inhibitors showed an improvement in cognition in patients with Alzheimer disease dementia but not in functionality.

Aducanumab Beneficial in Cognitive, Functional Scores for Alzheimer Disease

Aducanumab Beneficial in Cognitive, Functional Scores for Alzheimer Disease

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The analysis suggests a beneficial effect of aducanumab on functional and cognitive domain scores in adults with Alzheimer disease.

Memantine Plus Cholinesterase Inhibitors Improves Psychosis, Neurobehavioral Symptoms in Alzheimer Disease

Memantine Plus Cholinesterase Inhibitors Improves Psychosis, Neurobehavioral Symptoms in Alzheimer Disease

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Investigators pooled data from patients from 3 phase 3, 24-week, randomized, placebo-controlled trials of MEM in patients with Alzheimer disease receiving concurrent ChEIs.

Cognitive Impairment Profiles Differ Between Parkinson Disease and Alzheimer Disease

Cognitive Impairment Profiles Differ Between Parkinson Disease and Alzheimer Disease

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As the neurodegenerative processes of Alzheimer disease and Parkinson disease are different, early cognitive impairment also present differently in these diseases.

Benzodiazepines, Related Drugs Associated With Modestly Increased Risk for Alzheimer Disease

Benzodiazepines, Related Drugs Associated With Modestly Increased Risk for Alzheimer Disease

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Given the frequent use of benzodiazepines among older people, even a small increase in absolute risk may be a serious matter on a population level.

Trials for Investigational Alzheimer Treatment Lanabecestat Discontinued

Trials for Investigational Alzheimer Treatment Lanabecestat Discontinued

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Phase 3 clinical trials for lanabecestat (Eli Lilly and AstraZeneca), an investigational Alzheimer disease treatment, are being discontinued for futility.

Lifetime Risks Temper Biomarker Tests for Alzheimer Disease Dementia

Lifetime Risks Temper Biomarker Tests for Alzheimer Disease Dementia

The lifetime risks of Alzheimer disease dementia vary considerably by age, gender, and the preclinical or clinical disease state.

Intellectual Activities in Later Life May Cut Dementia Risk

Intellectual Activities in Later Life May Cut Dementia Risk

There is a reduced risk for dementia for older Chinese adults actively participating in intellectual activities.

Greater Wealth Associated With Lower Risk for Dementia in English Study

Greater Wealth Associated With Lower Risk for Dementia in English Study

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Public health strategies for preventing dementia should target socioeconomic gaps to reduce health disparities and protect the disadvantaged.

Anxiety: Feature of Late-Onset Dementia or Modifiable Risk Factor?

Anxiety: Feature of Late-Onset Dementia or Modifiable Risk Factor?

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The researchers encouraged clinicians not to rely solely on medication to treat midlife anxiety, as benzodiazepines have been shown to increase mortality in certain groups; they pointed to talk therapy, meditation, and mindfulness-based interventions as possible considerations.

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

FNIH Launches Project to Identify Biosignatures of Neurodegenerative, Psychiatric Conditions

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Multimarker inflammatory biosignatures are expected to facilitate diagnosis and predict treatment outcomes for various central nervous system disorders, particularly Alzheimer disease and major depressive disorder.

Depression in Patients With Dementia May Increase Risk for Heart Disease

Depression in Patients With Dementia May Increase Risk for Heart Disease

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Clinicians should take depression into careful consideration when treating patients with Alzheimer dementia, as the two conditions combined may predispose patients to cardiovascular disease more than either condition alone.

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

Clinically Significant Anxiety Tied to Subsequent Dementia Risk

These findings indicate that anxiety may be a risk factor for late-life dementia, excluding anxiety that is related to prodromal cognitive decline.

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

Mortality in Alzheimer Disease Not Strongly Associated With Antipsychotics

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These results suggest that antipsychotic exposure has no impact on relative mortality.

Traumatic Brain Injury Associated With Increased Risk for Dementia

Traumatic Brain Injury Associated With Increased Risk for Dementia

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These data support the importance of TBI preventative measures and proper management strategies for subsequent dementia.

Association Between Psychosis and Development of Dementia in Older Men

Association Between Psychosis and Development of Dementia in Older Men

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The findings also suggested that more a more recent diagnosis of psychosis was a greater predictor of the development of dementia, as opposed to cases where patients had been living with psychotic disorder diagnoses for 10 years or more.

Phonemic Verbal Advantage in Mild Cognitive Impairment May Predict Risk for Alzheimer Disease

Phonemic Verbal Advantage in Mild Cognitive Impairment May Predict Risk for Alzheimer Disease

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Patients with a phonemic advantage at baseline should be followed more closely with a higher index of suspicion for progression to Alzheimer disease.

Assessing Parental Symptom Onset Proximity in Alzheimer Disease

Assessing Parental Symptom Onset Proximity in Alzheimer Disease

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Investigators evaluated CSF Aβ1-42 levels obtained from individuals who presented no signs of cognitive dysfunction at enrollment and estimated the proximity of participants' age to their parents' age of AD symptom onset.

At-Home Program Aids Communication for Spouses With Dementia

At-Home Program Aids Communication for Spouses With Dementia

Spouses who are affected by dementia may benefit from an at-home dyadic, relationship-focused psychoeducational intervention.

Alcohol Use Disorder a Major Risk Factor in Dementia Onset

Alcohol Use Disorder a Major Risk Factor in Dementia Onset

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These findings support the recognition of alcohol use disorders as a major risk factor for all dementia types.

Predicting Progression From Normal Cognition to Mild Cognitive Impairment

Predicting Progression From Normal Cognition to Mild Cognitive Impairment

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There are a handful of biomarkers that offer potential value for predicting the risk for development of MCI symptoms from AD symptoms.

Systematic Review of Automated Cognitive Tests Yields Little Useful Clinical Guidance

Systematic Review of Automated Cognitive Tests Yields Little Useful Clinical Guidance

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The researchers noted that automated tests should not be used alone, but should instead be used as part of a comprehensive evaluation that must include clinical judgment and involve traditional assessor-guided cognitive batteries.

Dementia Risk Not Associated With Proton Pump Inhibitor Use

Dementia Risk Not Associated With Proton Pump Inhibitor Use

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Dementia risk was associated with neither proton pump inhibitor exposure nor duration of use.

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