Alzheimer’s Disease & Dementia
Amyloid deposits can lead to compromised myocardial function.
Researchers found that higher amyloid-β protein levels in saliva were significantly associated with Alzheimer's patients.
Eli Lilly's investigational Alzheimer's drug did not meet the primary end point in the phase 3 EXPEDITION3 trial.
These findings, combined with those from prior observational research, provide a solid rationale for further randomized trials.
A Cochrane systematic review found a clear lack of evidence for pharmacologic guidance of sleep problems in dementia.
Someone whose hippocampus stayed the same size was nearly 6 times more likely to develop Lewy body dementia.
Recognition of self-reported symptoms that may appear at early onset of amyloid accumulation, such as loneliness, point to opportunities for preventive therapies.
Findings suggest that efforts to encourage more planning aren't working.
The longer the duration of ADT, the greater the risk of dementia.
The American Heart Association issues a scientific statement on the possible link between chronic arterial hypertension and cognitive impairment.
In 2016, an estimated 5.4 million US adults have Alzheimer disease.
One hypothesis is that thyroid function affects dementia risk through nonvascular pathways.
Sundowning is a complex multifactorial condition that has eluded rigorous understanding of its pathophysiological causes.
Basic Research Findings for the Practicing Clinician
Dementia risk was particularly elevated in patients with depression who had higher scores on cognitive tests at baseline.
Those with lower BMI showed higher levels of beta-amyloid, closely tied to the onset of Alzheimer's disease.
Analysis of over 1.4 million Medicare beneficiaries found that fragmented care led to an additional $567 million to $1.1 billion in health care spending.
The findings suggest that interactions between beta-amyloid and tau lead to neurodegeneration in Alzheimer's.
Participants aged ≥65 years may have derived benefit from stimulation, while there was possible worsening in patients below age 65 years.
Cases of all-cause dementia and Alzheimer's did not significantly differ between study groups, but vascular care is safe and may reduce incidence of non-Alzheimer's dementia.
The effects of aggregate genetic AD risk are detectable before symptoms appear, even early in life.
Distinguishing between psychiatric disorders and AD is crucial because of the differing prognosis and management of the two.
If transmission of neurodegenerative diseases such as dementia of any type, AD, or PD does occur, it is rare.
Tetrahydrocannabinol (THC) is the main active chemical ingredient found in cannabis and is a potent cannabinoid receptor (CB)-1 agonist.
Modifiable risk factors (eg, smoking, hypertension, sedentary behavior, overweight/obesity, and social engagement) contribute to nearly half of documented dementia cases.
Cognitive test scores are negatively correlated with blood-brain barrier disruption in patients with early AD.
Although inconclusive, late-onset Alzheimer's Disease could be triggered by infectious pathogens.
Patients with atrial fibrillation who have been treated with warfarin may have an increased risk of developing dementia.
Researchers identified increased fibrinogen levels and amyloid-β deposits in the blood vessels and brain parenchyma of patients with Alzheimer's disease.
The case suggests that some patients with HIV and dementia may be misdiagnosed with HIV-associated brain disorders.
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