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ALDACTAZIDE
Edema
Hypertension
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Drug Name:

ALDACTAZIDE Rx

Generic Name and Formulations:
Spironolactone, hydrochlorothiazide; 25mg/25mg, 50mg/50mg+; tabs; +scored.

Company:
Pfizer Inc.

Therapeutic Use:

Indications for ALDACTAZIDE:

Edema.

Adult:

Not for initial therapy. Usual maintenance: 100mg each of spironolactone and HCTZ daily in single or divided doses. Range: 25mg–200mg of each component daily based on response to initial titration.

Children:

Not established.

Contraindications:

Anuria. Renal impairment. Hypercalcemia. Hyperkalemia. Addison’s disease. Sulfonamide allergy. Acute or severe hepatic failure.

Warnings/Precautions:

History of allergy or bronchial asthma. Hyponatremia. Gout. Diabetes. SLE. Postsympathectomy. Acute myopia and secondary angle-closure glaucoma. Monitor electrolytes periodically. Metabolic disturbances. Monitor calcium levels in hypercalcemia. Hepatic impairment. Severe renal disease. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Avoid K+ sparing diuretics, K+ supplements, K+ containing salt substitutes, lithium. Hyperkalemia more likely with ACE inhibitors, ARBs, aldosterone blockers, NSAIDs, heparin, LMWH. Hypokalemia with corticosteroids, ACTH. Potentiates alcohol, barbiturates, narcotics, skeletal muscle relaxants, antihypertensives. Reduced response to pressor amines (eg, norepinephrine). May need to adjust insulin or oral hypoglycemic dosage. Caution with cholestyramine. Antagonized by NSAIDs. Digitalis toxicity. May interfere with parathyroid tests.

Pharmacological Class:

Diuretic (K+ sparing) + (thiazide).

Adverse Reactions:

Hyperkalemia, gynecomastia, diarrhea, vomiting, nausea, somnolence, dizziness, headache, rash, confusion, fever, ataxia, menstrual changes, gastric ulcers, electrolyte disorders (esp. hypokalemia, hypomagnesemia), hyperglycemia, hyperuricemia, blood dyscrasias, photosensitivity, orthostatic hypotension, adverse lipid values.

How Supplied:

Tabs—100

Indications for ALDACTAZIDE:

Hypertension.

Adult:

Not for initial therapy. Usual maintenance: 50–100mg each of spironolactone and HCTZ daily in single or divided doses.

Children:

Not established.

Contraindications:

Anuria. Renal impairment. Hypercalcemia. Hyperkalemia. Addison’s disease. Sulfonamide allergy. Acute or severe hepatic failure.

Warnings/Precautions:

History of allergy or bronchial asthma. Hyponatremia. Gout. Diabetes. SLE. Postsympathectomy. Acute myopia and secondary angle-closure glaucoma. Monitor electrolytes periodically. Metabolic disturbances. Monitor calcium levels in hypercalcemia. Hepatic impairment. Severe renal disease. Elderly. Pregnancy (Cat.C). Nursing mothers: not recommended.

Interactions:

Avoid K+ sparing diuretics, K+ supplements, K+ containing salt substitutes, lithium. Hyperkalemia more likely with ACE inhibitors, ARBs, aldosterone blockers, NSAIDs, heparin, LMWH. Hypokalemia with corticosteroids, ACTH. Potentiates alcohol, barbiturates, narcotics, skeletal muscle relaxants, antihypertensives. Reduced response to pressor amines (eg, norepinephrine). May need to adjust insulin or oral hypoglycemic dosage. Caution with cholestyramine. Antagonized by NSAIDs. Digitalis toxicity. May interfere with parathyroid tests.

Pharmacological Class:

Diuretic (K+ sparing) + (thiazide).

Adverse Reactions:

Hyperkalemia, gynecomastia, diarrhea, vomiting, nausea, somnolence, dizziness, headache, rash, confusion, fever, ataxia, menstrual changes, gastric ulcers, electrolyte disorders (esp. hypokalemia, hypomagnesemia), hyperglycemia, hyperuricemia, blood dyscrasias, photosensitivity, orthostatic hypotension, adverse lipid values.

How Supplied:

Tabs—100

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