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Drug Name:


Generic Name and Formulations:
Fluticasone propionate, salmeterol (as xinafoate) 55mcg/14mcg, 113mcg/14mcg, 232mcg/14mcg; per actuation; dry pwd for oral inh with a dose counter.

Teva Pharmaceuticals

Therapeutic Use:

Indications for AIRDUO RESPICLICK:

Treatment of asthma.

Limitations Of use:

Not for the relief of acute bronchospasm.


Allow approx. 12hrs between doses. Take at same time each day. Rinse mouth after each dose. Not previously on inhaled steroid: 1 inh of 55/14mcg twice daily; already on inhaled steroid: see full labeling. If insufficient response after 2wks, use next higher strength. Max 1 inh of 232/14mcg twice daily. Titrate to lowest effective dose after stability achieved.


<12yrs: not established.


Primary treatment of status asthmaticus or other acute episodes of asthma requiring intensive measures. Severe milk protein hypersensitivity.


Increased risk of asthma-related deaths and hospitalizations. Do not initiate in rapidly or acutely deteriorating asthma. Not for use with other long-acting β2-agonists. Do not exceed recommended dose. Prescribe a short-acting, inhaled β2-agonist for acute symptoms; monitor for increased need. Immunosuppressed. Tuberculosis. Systemic infections. Ocular herpes simplex. If exposed to chickenpox or measles, consider immune globulin or antiviral ­prophylactic therapies. Monitor for signs/symptoms of adrenal insufficiency when transferring from systemic steroids. May need supplemental systemic corticosteroids during periods of stress or a severe asthma attack. May unmask previously suppressed allergic conditions. Reevaluate periodically. Monitor for hypercorticism and HPA axis suppression (if occurs, discontinue gradually), growth in children, visual changes, or with a history of increased intraocular pressure, glaucoma, and/or cataracts. Discontinue if paradoxical bronchospasm occurs; use alternative therapy. Cardiovascular disease (esp. coronary insufficiency, arrhythmias, hypertension). Eosinophilic conditions. Convulsive disorders. Thyrotoxicosis. Hyperresponsiveness to sympathomimetics. Diabetes. Ketoacidosis. Hypokalemia. Hyperglycemia. Hepatic impairment: monitor. Assess bone mineral density if risk factors exist (eg, prolonged immobilization, osteoporosis, or chronic use of drugs that can reduce bone mass [eg, anticonvulsants, oral steroids]). Do not use with spacers. Pregnancy: monitor closely. Nursing mothers.


Concomitant strong CYP3A4 inhibitors (eg, ketoconazole, itraconazole, ritonavir, atazanavir, clarithromycin, indinavir, nefazodone, nelfinavir, saquinavir, telithromycin): not recommended. Caution with other sympathomimetics (except short-acting bronchodilators), during or within 2 weeks of MAOIs, tricyclic antidepressants, K+–depleting diuretics. Antagonized by β-blockers; avoid if no alternatives, consider cardio-selective β-blockers.

Pharmacological Class:

Steroid + long-acting beta-2 agonist.

Adverse Reactions:

Nasopharyngitis, oral candidiasis, back pain, headache, cough; hypersensitivity reactions; rarely: serious asthma episode, asthma-related death.

Generic Availability:


How Supplied:

RespiClick (60 actuations)—1

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