Weekly or monthly buprenorphine depot injections were non-inferior to daily sublingual buprenorphine/naloxone in maintaining no evidence of illicit opioid use at 24 weeks in outpatients with opioid use disorder.
Unit-dose packaging of buprenorphine-naloxone associated with reduced pediatric unintentional exposuresMay 22, 2018
Pediatric unintentional opioid exposures decreased by more than 75% following the introduction of child-resistant unit-dose packaging.
Patients who use medical marijuana may be more likely to use prescription drugs for both medical and nonmedical purposes.
Lucemyra, a selective alpha 2-adrenergic receptor agonist, works by reducing the release of norepinephrine and decreasing sympathetic tone.
Receipt of opioid-related payments from industry in 2014 was associated with increased opioid prescribing in 2015.
Participants in the prazosin group were more likely to experience dizziness on standing.
Investigators pooled data from 2 phase 3 placebo-controlled studies to evaluate the safety and efficacy of lofexidine for opioid withdrawal symptoms.
Recent physician-prescribed opioids represent the main source of provenance of the drug in individuals age ≥65 years who misuse them.
Opioids were the leading contributor to drug overdose deaths between 2015 and 2016.
Investigators examined the prevalence of prescription stimulant use, misuse, use disorder, and motivations for misuse in adults in the US from 2015 to 2016.
These data may be helpful in titrating care for those with schizotypal disorder and comorbid substance abuse disorders to mitigate the risk for conversion to schizophrenia.
There were no observable differences in the incidence of any cardiovascular events across the smoking cessation treatment groups.
Methadone Maintenance Therapy Associated With Greater Access to Physician Care in HCV-Positive Drug UsersApril 30, 2018
The investigators suggest that enrollment in a methadone maintenance therapy program may be helpful in providing access to HCV care in people who inject drugs.
For millennials, sun protection knowledge is not associated with addictive tanning behavior.
Although there were no indications of esketamine dependence, misuse, diversion, or withdrawal symptoms in this trial, this is a possible concern, and the authors call for further evidence from clinical trials to evaluate the drug's potential for abuse.
April 28, 2018 is National Prescription Drug Take Back Day.
The concept of internet gaming disorder and the pathways leading to it are unclear.
The results of this study suggest that children prenatally exposed to substances should receive early mental health assessment.
A number of factors including chronic pain co-occurring with posttraumatic stress disorder and pain interference may predict suicidal ideation and violent impulses in US veterans with chronic pain.
Katie Burk, MPH, presented measures undertaken by the city of San Francisco to provide integrated responses to the concurrent HIV/HCV and opioid public health epidemics.
Both modified cognitive behavioral therapy (CBT) and pain education (EDU) interventions were associated with improved pain in patients with disadvantaged backgrounds.
Mortality rates decreased for alcohol use disorders, self-harm, and interpersonal violence between 1980 and 2014. Mortality rates for drug use disorders increased both nationally and in each county over the same period.
Package inserts of opioid analgesics may not consistently provide information regarding safe drug storage and/or disposal.
A longer duration of extended-release naltrexone treatment in individuals with opioid dependence was associated with improved outcomes and reduced rates of relapse.
Because even moderate reductions in adolescent drinking and alcohol use disorders have the potential to reduce short- and long-term public health harms, these findings support broad implementation of the program.
The investigators found that antisocial (β=0.23) and borderline (β=0.20) personality disorders were strongly associated with cannabis use as well as with cannabis use disorder.
The findings of these analyses suggest that, to an extent, this relationship might be generalized to cannabis users as a whole, not just those diagnosed with a cannabis use disorder.
The more chemicals in e-liquid, the more toxic it is likely to be.
Online marijuana searches grew by 98 percent as a proportion of all searches from 2005 to 2017.
If approved, Lucemyra will be the first non-opioid medication indicated to mitigate opioid withdrawal symptoms.
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