Generic Name and Formulations:
Corticorelin ovine (as the trifluoroacetate) 100mcg/vial; pwd for IV inj after reconstitution.
Ferring Pharmaceuticals, Inc.
Indications for ACTHREL:
For use in differentiating pituitary and ectopic production of ACTH in patients with ACTH-dependent Cushings syndrome.
Adults and Children:
Testing pituitary corticotrophin function: 1mcg/kg IV as a single dose. ACTH and cortisol response prolonged and remain elevated for up to 2 hours. Doses >1mcg/kg: not recommended. If repeat test needed, do tests at the same time of day as original test.
Higher doses associated with transient tachycardia, decreased BP, loss of consciousness, and asystole; symptoms may be reduced if given as a 30 second IV infusion instead of bolus inj. Pregnancy (Cat.C). Nursing mothers.
Plasma ACTH response inhibited by dexamethasone. Heparin to maintain IV cannula patency: not recommended.
Corticotropin-releasing hormone (CRH) analogue.
Flushing of the face, neck, upper chest; tachycardia, hypotension, dyspnea, chest compression or tightness with higher doses.
Psychiatry Advisor Articles
- ACOG Update: Marijuana Use Discouraged During Pregnancy, Breastfeeding
- Asenapine Prevents Recurrence of Mood Events in Bipolar Disorder
- Continuing Research, Emerging Treatments Hold Promise for Treating Anorexia Nervosa
- Depression Profiles in Patients With Type 1 Diabetes vs Type 2 Diabetes
- Purpose, Questions of Social Interaction Lead Physicians to Delay Retirement
- CBT, Acceptance Commitment Therapy Helpful for Those With Chronic Pain
- Suicidal Behavior, Thoughts Associated With Perfectionist Tendencies
- Depression Reduced by Social Belonging, Feelings of Inclusion
- Sleep Disturbance May Be Causal Factor in Psychotic Experiences
- Is Antidepressant Use in Pregnancy Tied to Psychiatric Disorders in Offspring?
- Cardiovascular Risk Management May Slow Neurocognitive Decline in HIV
- Maintenance rTMS for Treatment-Resistant Depression
- New Study Compares Opioid Dependence Relapse Treatments
- Increase Use of Nursing Home for Patients With Cognitive Impairment Category
- Venlafaxine XR Safe, Effective in Treating Generalized Anxiety Disorder